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GATA4 encodes a member of the GATA family of zinc-finger transcription factors. Additionally we are shipping GATA4 Kits (38) and GATA4 Proteins (11) and many more products for this protein.
Showing 10 out of 193 products:
Human Monoclonal GATA4 Primary Antibody for BI, WB - ABIN967667
Oka, Xu, Molkentin: Re-employment of developmental transcription factors in adult heart disease. in Seminars in cell & developmental biology 2007
Show all 3 references for ABIN967667
Human Monoclonal GATA4 Primary Antibody for ELISA, WB - ABIN969169
Rajagopal, Ma, Obler, Shen, Manichaikul, Tomita-Mitchell, Boardman, Briggs, Garg, Srivastava, Goldmuntz, Broman, Benson, Smoot, Pu: Spectrum of heart disease associated with murine and human GATA4 mutation. in Journal of molecular and cellular cardiology 2007
Show all 3 references for ABIN969169
Human Polyclonal GATA4 Primary Antibody for EIA, WB - ABIN4620502
Philips, Kwok, Chong: Analysis of the signals and mechanisms mediating nuclear trafficking of GATA-4. Loss of DNA binding is associated with localization in intranuclear speckles. in The Journal of biological chemistry 2007
Show all 2 references for ABIN4620502
Human Polyclonal GATA4 Primary Antibody for ELISA, WB - ABIN1533735
Huang, Cukerman, Liew: Identification of a GATA motif in the cardiac alpha-myosin heavy-chain-encoding gene and isolation of a human GATA-4 cDNA. in Gene 1995
Show all 2 references for ABIN1533735
Human Polyclonal GATA4 Primary Antibody for IF, ELISA - ABIN1532617
Garg, Kathiriya, Barnes, Schluterman, King, Butler, Rothrock, Eapen, Hirayama-Yamada, Joo, Matsuoka, Cohen, Srivastava: GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. in Nature 2003
Show all 2 references for ABIN1532617
Human Monoclonal GATA4 Primary Antibody for WB - ABIN2452241
Huang, Chen, Hwang, Yu, Su, Mai, Wang, Cheng, Schuyler, Ma, Lu, Lu: miR-200c and GATA binding protein 4 regulate human embryonic stem cell renewal and differentiation. in Stem cell research 2014
Dog (Canine) Polyclonal GATA4 Primary Antibody for WB - ABIN2780394
Anttonen, Unkila-Kallio, Leminen, Butzow, Heikinheimo: High GATA-4 expression associates with aggressive behavior, whereas low anti-Müllerian hormone expression associates with growth potential of ovarian granulosa cell tumors. in The Journal of clinical endocrinology and metabolism 2005
Data show that GATA4 or 6 regulate both cardiogenic potential and subsequent cardiomyocyte differentiation but that GATA5 is involved in regulating cardiomyocyte differentiation.
Results describe the expression of GATA4 and 6 during gastrulation and their function in migratory behaviour.
The data demonstrate that KLF13 (show KLF13 Antibodies) is an important component of the transcription network required for heart development and suggest that KLF13 (show KLF13 Antibodies) is a GATA-4 modifier
Data show that GATA4 knockdown only affects cardiac marker expression in the absence of either GATA5 or GATA6, suggesting redundancy in this family during myocardial development.
These results indicate a higher capacity of adipose-derived than bone marrow-derived mesenchymal stem cells to express GATA4.
Study demonstrated downregulation of expression of pancreatic master genes SOX9 (show SOX9 Antibodies), FOXA2 (show FOXA2 Antibodies), and GATA4 (2-, 5-, and 4-fold, respectively) and in PANC1 pancreatic cancer cell line stimulated with TGFbeta1 (show TGFB1 Antibodies)
Mutations of GATA4 appear to be responsible for some cardiac septal defects. The aim of this work was to screen for mutations in the GATA4 gene in sample of Egyptian patients affected by isolated and non-isolated cardiac septal defects. Identified are two coding variants and four non-coding ones of GATA4 gene, but further confirmation study for familial segregation detection was recommended.
The definitive endoderm and foregut endoderm differentiation capabilities of Wnt (show WNT2 Antibodies) pathway-modulated cells were determined based on the expression levels of the endodermal transcription factors SOX17 (show SOX17 Antibodies) and FOXA2 (show FOXA2 Antibodies) and those of the transcription activator GATA4 and the alpha-fetoprotein (AFP (show AFP Antibodies)) gene, respectively.
NKX2.5 (show NKX2-5 Antibodies) and GATA4 gene mutations might participate in the development of congenital heart disease and can promote bone marrow derived stroma cell differentiate into cardiomyocytes.
There was no evidence of a role for NKX2-5 (show NKX2-5 Antibodies) and GATA4 CNV in fetal CHD (show CHDH Antibodies); therefore, these CNV may not be common in fetal CHD (show CHDH Antibodies) in China
results demonstrate that cGMP-PKG (show PRKG1 Antibodies) signaling mediates transcriptional activity of GATA4 and links defective GATA4 and PKG (show PRKG1 Antibodies)-1alpha mutations to the development of human heart disease.
This study showed that GATA4 gene involved in neuronal growth and cerebellum development and associated with neurological and psychological disorders.
Kaplan-Meier survival analysis revealed significantly shorter overall survival in pediatric Acute myeloid leukemia (show BCL11A Antibodies) with GATA4 promoter methylation but multivariate analysis shows that it is not an independent factor.
Data show that the combination of GATA binding protein 4 (Gata4), T-box transcription factor 5 (Tbx5 (show TBX5 Antibodies)) and BRG1-associated factor 60C (show SMARCD3 Antibodies) protein (Baf60c (show SMARCD3 Antibodies)) is sufficient for inducing adipose tissue-derived mesenchymal stem cells (ADMSCs) to form cardiomyocytes.
we identified a mutation in the GATA4 Kozak sequence that likely contributes to the pathogenesis of Atrial septal defect.
investigation of genes regulated by GATA4, GATA6 (show GATA6 Antibodies), and both in combination: studies in granulosa cells primed for luteinization
GATA-4 and C/EBPbeta (show CEBPB Antibodies) are both required for FSH (show BRD2 Antibodies) +/- IGF-I (show IGF1 Antibodies) stimulation of the porcine steroidogenic acute regulatory protein (show STAR Antibodies) gene promoter in homologous granulosa cell cultures.
The altered ratio of GATA4 to GATA6 (show GATA6 Antibodies) after ovulation may allow GATA6 (show GATA6 Antibodies) to enhance STAR mRNA accumulation.
Histone acetylation/methylation and DNA methylation (show HELLS Antibodies) were both involved in regulating GATA4 expression, but Nkx2.5 (show NKX2-5 Antibodies) expression was not regulated by DNA methylation (show HELLS Antibodies). These three modifications had high correlation with each other during regulation of GATA4 and produced a regulation loop at the GATA4 promoter.
GATA4 acts as a negative regulator of Bsp (show KLK6 Antibodies) expression in osteoblasts.
Detailed analysis of specific lineage markers expression showed selective downregulation of endoderm markers in REST-null cells, thus contributing to a loss of cardiogenic signals. REST regulates cardiac differentiation of ESCs (show NR2E3 Antibodies) by negatively regulating the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway and positively regulating the cardiogenic TF Gata4
GATA4 and GATA6 (show GATA6 Antibodies) are essential for female fertility, whereas targeting either factor alone causes subfertility. GATA4 and GATA6 (show GATA6 Antibodies) are also required for the expression of the receptors for prolactin (show PRL Antibodies) and luteinizing hormone.
Loss of Gata4 in Sertoli cells impairs the spermatogonial stem cell niche and causes germ cell exhaustion by attenuating chemokine (show CCL1 Antibodies) signaling.
data support the concept that under physiological conditions microbiota stimulate Gata4, which suppresses Asbt (show SLC10A2 Antibodies) expression
MITF (show MITF Antibodies) interacts with BRG1 (show SMARCA4 Antibodies) to promote GATA4 expression in cardiac hypertrophy.
Data show that three transcriptional factors Gata4, Mef2c (show MEF2C Antibodies), and Tbx5 (show TBX5 Antibodies) (abbreviated as GMT (show GAMT Antibodies)) significantly improved murine embryonic stem cells (ESCs (show NR2E3 Antibodies)) differentiated into cardiomyocytes.
the data suggest that the inhibitory effects of melatonin on testosterone production are mediated via down-regulation of GATA-4 and SF-1 (show SF1 Antibodies) expression.
GATA4/6-mediated inhibition of hedgehog (show SHH Antibodies) signaling is a major mechanism regulating pancreatic endoderm specification during patterning of the gut (show GUSB Antibodies) tube
The activity of Gata4 cardiac enhancer in transgenic embryos and in cultured aortic endothelial cells is dependent on four ETS (show ETS1 Antibodies) sites.
Study finds that emergent juvenile cortical cardiomyocytes induce expression of gata4 in a manner similar to during regeneration.
ATOH8 (show ATOH8 Antibodies), GATA4, and FOG2 (show ZFPM2 Antibodies) associate in a single complex
gata4 gene regulates sdf1a (show CXCL12 Antibodies) levels during early embryogenesis
mga (show MGA Antibodies) restricts the normal levels of Gata4 required for heart tube looping.
Through the use of a transgenic reporter strain, we found that cardiomyocytes throughout the subepicardial ventricular layer trigger expression of the embryonic cardiogenesis gene gata4 within a week of trauma
Gata4 and Gata6 (show GATA6 Antibodies) have distinct non-redundant functions in cardiac morphogenesis (show XIRP1 Antibodies), but are redundant for an early step of liver development; and Gata4 and Gata6 (show GATA6 Antibodies) are essential and non-redundant for liver growth following initial budding
Data show that GATA4 knockdown only affects cardiac marker expression in the absence of either GATA5 (show GATA6 Antibodies) or GATA6 (show GATA6 Antibodies), suggesting redundancy in this family during myocardial development.
Results suggest that GATA4 and -6 play a key role in the regulation of ventricular myosin heavy chain gene expression in the ventricle.
This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects.
GATA binding protein 4
, glutamyl-tRNA(Gln) amidotransferase subunit A
, GATA-4 zinc-finger transcription factor
, gata4 transcription factor
, GATA-4 transcription factor
, GATA-binding factor 4
, transcription factor GATA-4
, GATA-binding protein 4
, DNA-binding protein GATA-GT2
, transcription factor GATA4
, transcription factor xGATA-4