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GATA6 is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. Additionally we are shipping GATA6 Antibodies (129) and GATA6 Kits (4) and many more products for this protein.
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GATA6 induces expression of genes essential for growth of colon cancer cells under adherent conditions (REG4 (show REG4 Proteins)) and genes required for their clonogenicity (LGR5 (show LGR5 Proteins)), and miR (show MLXIP Proteins)-363-GATA6-REG4 (show REG4 Proteins)/LGR5 (show LGR5 Proteins) signaling cascade promotes tumorigenicity of colon cancer cells.
In the pancreas, Gata6 acts as a tumour suppressor by enforcing acinar cell differentiation, by directly and indirectly repressing ectopic differentiation programmes, and by regulating crucial cancer-related gene expression pathways.
Our results, for the first time, portray a pivotal role of GATA6 in regulating metastatic behaviors of breast cancer cells
miR (show MLXIP Proteins)-181b was upregulated by hypoxia in retinoblastoma in an HIF-1a (show HIF1A Proteins)-independent manner. Additionally, miR (show MLXIP Proteins)-181b exerts its angiogenic function, at least in part, by inhibiting PDCD10 (show PDCD10 Proteins) and GATA6.
data indicated that GATA-6 and Akt2 (show AKT2 Proteins) are involved in the mTORC1-mediated regulation of VSMC proliferation and differentiation.
results show how genetic mutations in GATA6 may lead to functional inactivity and pancreatic agenesis in humans
GATA6 expression is progressively increased during Barrett's oesophagus development and its malignant transformation to esophageal adenocarcinoma.
KLF5 (show KLF5 Proteins)/GATA4 (show GATA4 Proteins)/GATA6 may promote gastric cancer development by engaging in mutual crosstalk, collaborating to maintain a pro-oncogenic transcriptional regulatory network in gastric cancer cells.
association of GATA6 loss-of-function mutations with enhanced susceptibility to familial dilated cardiomyopathy
These results establish SHP (show LAMC1 Proteins) as a novel antihypertrophic regulator that acts by interfering with GATA6 signaling.
GATA4 (show GATA4 Proteins) and GATA6 mRNA and proteins could be detected in bovine corpus luteum (CL). GATA6 showed a marked decrease at the regressed luteal stage, like NR5A1 (show NR5A1 Proteins), NR5A2 (show NR5A2 Proteins), and the other steroidogenic markers.
GATA4 (show GATA4 Proteins) and GATA6 are essential for female fertility, whereas targeting either factor alone causes subfertility. GATA4 (show GATA4 Proteins) and GATA6 are also required for the expression of the receptors for prolactin (show PRL Proteins) and luteinizing hormone.
GATA4 (show GATA4 Proteins)/6-mediated inhibition of hedgehog (show SHH Proteins) signaling is a major mechanism regulating pancreatic endoderm specification during patterning of the gut (show GUSB Proteins) tube
The role of GATA4 (show GATA4 Proteins) in the regulation of cardiomyocyte maturation in the newborn heart and in maintaining diastolic function in the adult heart.
GATA6 contributes to the development and postnatal function of the murine atrioventricular node by promoting cell-cycle exit of specified cardiomyocytes toward a conduction system lineage.
Gata6 is a versatile and potent reprograming factor that can act alone to drive a cell fate switch from diverse cell types
Mice with double deletion of Gata4 (show GATA4 Proteins) and Gata6 lack identifiable adrenal glands. Inactivation of Gata6 alone drastically reduced the adrenal size and corticosterone production in the adult animals.
GATA6 likely regulates enteroendocrine cell differentiation cell autonomously whereas GATA4 (show GATA4 Proteins) affects this population indirectly
these data suggest an essential role for Pak1 (show PAK1 Proteins) as an Erk (show MAPK1 Proteins) activator, and Gata6 as an Erk (show MAPK1 Proteins) target, during neural crest development.
specification of cardiac fate downstream of gata5/6 involves activation of the tmem88a gene to constrain WNT (show WNT2 Proteins) signaling and expand the number of cardiac progenitors.
in zebrafish the gata6 genes are redundant for specification of cardiomyocytes.
Results suggest that GATA4 and -6 play a key role in the regulation of ventricular myosin heavy chain gene expression in the ventricle.
investigation of genes regulated by GATA6, GATA4 (show GATA4 Proteins), and both in combination: studies in granulosa cells primed for luteinization
The altered ratio of GATA4 (show GATA4 Proteins) to GATA6 after ovulation may allow GATA6 to enhance STAR mRNA accumulation.
This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects.
zinc-finger transcription factor Gata6
, GATA binding protein 6
, transcription factor GATA-6-like
, GATA-binding factor 6
, transcription factor GATA-6
, GATA-6 transcription factor
, GATA-binding protein 6
, DNA-binding protein GATA-GT2