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GATA6 is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. Additionally we are shipping GATA6 Antibodies (129) and GATA6 Proteins (6) and many more products for this protein.
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Knockdown of GATA6 completely eliminated the effect of TCF1 (show HNF1A ELISA Kits), while forced expression of GATA6 induced hESC differentiation
In human Pancreatic Ductal Adenocarcinoma cells, GATA6 inhibits de-differentiation and epithelial-mesenchymal transition both directly and indirectly, through mechanism that involves the regulation of transcription factors, including FOXA1 (show FOXA1 ELISA Kits)/2.Loss of GATA6 in PDAC primary samples is associated with altered differentiation and shorter overall patient survival.
GATA6 induces expression of genes essential for growth of colon cancer cells under adherent conditions (REG4 (show REG4 ELISA Kits)) and genes required for their clonogenicity (LGR5 (show LGR5 ELISA Kits)), and miR (show MLXIP ELISA Kits)-363-GATA6-REG4 (show REG4 ELISA Kits)/LGR5 (show LGR5 ELISA Kits) signaling cascade promotes tumorigenicity of colon cancer cells.
In the pancreas, Gata6 acts as a tumour suppressor by enforcing acinar cell differentiation, by directly and indirectly repressing ectopic differentiation programmes, and by regulating crucial cancer-related gene expression pathways.
Our results, for the first time, portray a pivotal role of GATA6 in regulating metastatic behaviors of breast cancer cells
miR (show MLXIP ELISA Kits)-181b was upregulated by hypoxia in retinoblastoma in an HIF-1a (show HIF1A ELISA Kits)-independent manner. Additionally, miR (show MLXIP ELISA Kits)-181b exerts its angiogenic function, at least in part, by inhibiting PDCD10 (show PDCD10 ELISA Kits) and GATA6.
data indicated that GATA-6 and Akt2 (show AKT2 ELISA Kits) are involved in the mTORC1-mediated regulation of VSMC proliferation and differentiation.
results show how genetic mutations in GATA6 may lead to functional inactivity and pancreatic agenesis in humans
GATA6 expression is progressively increased during Barrett's oesophagus development and its malignant transformation to esophageal adenocarcinoma.
KLF5 (show KLF5 ELISA Kits)/GATA4 (show GATA4 ELISA Kits)/GATA6 may promote gastric cancer development by engaging in mutual crosstalk, collaborating to maintain a pro-oncogenic transcriptional regulatory network in gastric cancer cells.
GATA4 (show GATA4 ELISA Kits) and GATA6 mRNA and proteins could be detected in bovine corpus luteum (CL). GATA6 showed a marked decrease at the regressed luteal stage, like NR5A1 (show NR5A1 ELISA Kits), NR5A2 (show NR5A2 ELISA Kits), and the other steroidogenic markers.
these findings indicated that the downregulation of GATA-6 effectively inhibited airway inflammation and reversed airway remodeling via Cav-1 (show CAV1 ELISA Kits)
During wound healing differentiated Gata6(+) cells migrate from the sebaceous duct into the interfollicular epidermis and dedifferentiate, acquiring the ability to undergo long-term self-renewal and differentiate into a much wider range of epidermal lineages than in undamaged tissue.
The authors find that Gata6 protects against DNA damage associated with proliferation, thus preventing cell cycle arrest and apoptosis.
Findings indicate that the Gata6 promoter is activated by Esrrb (show ESRRB ELISA Kits) in association with Ncoa3 (show NCOA3 ELISA Kits), and Dax1 (show NR0B1 ELISA Kits) inhibited activities of Esrrb (show ESRRB ELISA Kits) and Ncoa3 (show NCOA3 ELISA Kits), resulting maintenance of the undifferentiated status of embryonic stem (ES) cells.
GATA4 (show GATA4 ELISA Kits) and GATA6 are essential for female fertility, whereas targeting either factor alone causes subfertility. GATA4 (show GATA4 ELISA Kits) and GATA6 are also required for the expression of the receptors for prolactin (show PRL ELISA Kits) and luteinizing hormone.
GATA4 (show GATA4 ELISA Kits)/6-mediated inhibition of hedgehog (show SHH ELISA Kits) signaling is a major mechanism regulating pancreatic endoderm specification during patterning of the gut (show GUSB ELISA Kits) tube
The role of GATA4 (show GATA4 ELISA Kits) in the regulation of cardiomyocyte maturation in the newborn heart and in maintaining diastolic function in the adult heart.
these data suggest an essential role for Pak1 (show PAK1 ELISA Kits) as an Erk (show MAPK1 ELISA Kits) activator, and Gata6 as an Erk (show MAPK1 ELISA Kits) target, during neural crest development.
specification of cardiac fate downstream of gata5/6 involves activation of the tmem88a gene to constrain WNT (show WNT2 ELISA Kits) signaling and expand the number of cardiac progenitors.
in zebrafish the gata6 genes are redundant for specification of cardiomyocytes.
Results suggest that GATA4 and -6 play a key role in the regulation of ventricular myosin heavy chain gene expression in the ventricle.
investigation of genes regulated by GATA6, GATA4 (show GATA4 ELISA Kits), and both in combination: studies in granulosa cells primed for luteinization
The altered ratio of GATA4 (show GATA4 ELISA Kits) to GATA6 after ovulation may allow GATA6 to enhance STAR mRNA accumulation.
This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects.
zinc-finger transcription factor Gata6
, GATA binding protein 6
, transcription factor GATA-6-like
, GATA-binding factor 6
, transcription factor GATA-6
, GATA-6 transcription factor
, GATA-binding protein 6
, DNA-binding protein GATA-GT2