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Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. Additionally we are shipping GDNF Family Receptor alpha 1 Proteins (19) and GDNF Family Receptor alpha 1 Kits (9) and many more products for this protein.
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Human Polyclonal GFRA1 Primary Antibody for IHC, ELISA - ABIN1002344
Treanor, Goodman, de Sauvage, Stone, Poulsen, Beck, Gray, Armanini, Pollock, Hefti, Phillips, Goddard, Moore, Buj-Bello, Davies, Asai, Takahashi, Vandlen, Henderson, Rosenthal: Characterization of a multicomponent receptor for GDNF. in Nature 1996
Show all 4 references for ABIN1002344
This study demonstrate, using a knock-in mouse model in which GFRalpha1 is no longer located in lipid rafts, that the developmental functions of GDNF (show GDNF Antibodies) in the periphery require the translocation of the GDNF (show GDNF Antibodies) receptor complex into lipid rafts.
Methylation changes of GFRA1, SRF, and ZNF382 (show ZNF382 Antibodies) may be a potential biomarker set for prediction of gastric carcinoma metastasis.
GFRalpha1 levels in neurons from autopsied AD brains are significantly decreased.
These findings collectively demonstrate that GFRalpha1 released by nerves enhances perineural invasion through GDNF (show GDNF Antibodies)-RET (show RET Antibodies) signaling and that GFRalpha1 expression by cancer cells enhances but is not required for it.
The study shows co-localization of RET (show RET Antibodies) with GFRA1 and GFRA2 (show GFRA2 Antibodies) in myenteric ganglia of the adult human colon.
The expression of GFRalpha1 and/or GFRalpha3 (show GFRA3 Antibodies), especially when combined with ARTN (show ARTN Antibodies) expression, may be useful predictors of disease progression and outcome in specific subtypes of mammary carcinoma.
Mutations in GFRA1 gene is associated with urinary tract malformations.
Post-synaptic transgenic GFRalpha1 has profound effects on the development of dopamine neurons, resulting in a 40% increase in the adult number.
This study found nominally-significant evidence for interactions between GFRA1, 2 and 3 associated with schizophrenia and clozapine response, consistent with the locations of these three genes within linkage regions for schizophrenia.
Results identify persephin (show PSPN Antibodies), a GDNF (show GDNF Antibodies) family member, as a novel ligand for GFRalpha1/RET (show RET Antibodies) receptor complex.
Gfra1 expression in the urinary tract strictly depends on cell-type and specific stage in kidney development.
SorLA (show SORL1 Antibodies) acts as sorting receptor for the GDNF (show GDNF Antibodies)/GFRalpha1 complex, directing it from the cell surface to endosomes.
our data demonstrate that RET (show RET Antibodies)/GFRalpha signals are dispensable for thymic T cell development in vivo
GFRalpha1 is critical for the development and function of the main olfactory system, contributing to the development and allocation of all major classes of neurons and glial cells.
Donor-derived GFRalpha1-positive cells formed several aggregates of A(al(aligned)) /morula-like structures in a single spermatogenic cell patch before and on day 14 post-transplant, indicating involvement in the formation of a stable spermatogenic colony.
GFRA1 expression is regulated by GDNF (show GDNF Antibodies) and in cultures of isolated seminiferous tubules, we found that GDNF (show GDNF Antibodies) expression and secretion by Sertoli cells is stage-dependent, being maximal in stages II-VI and decreasing thereafter.
Histone methylation and acetylation regulate Pou5f1 (show POU5F1 Antibodies) and Gfra1 in male germ cell.
Following ischemic injury, GFR alpha-1 is differentially up-regulated in GFR alpha-1 (+/+) and GFR alpha-1 (+/-) mice.
GDNF (show GDNF Antibodies)/GFRalpha1 are involved in the survival and differentiation of double negative immature thymocytes.
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene.
GDNF family receptor alpha 1
, GDNF family receptor alpha-1
, GDNF family receptor alpha-1-like
, GDNF receptor alpha-1
, GPI-linked anchor protein
, Glial cell line-derived neurotrophic factor receptor alpha
, PI-linked cell-surface accessory protein
, RET ligand 1
, TGF-beta related neurotrophic factor receptor 1
, TGF-beta-related neurotrophic factor receptor 1
, GDNF receptor alpha
, glial cell line derived neurotrophic factor family receptor alpha 1
, GFR alpha-1