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GDNF Family Receptor alpha 2 (GFRA2) ELISA Kits

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. Additionally we are shipping GFRA2 Antibodies (72) and GFRA2 Proteins (13) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human GFRA2 GFRA2 2675 O00451
Anti-Rat GFRA2 GFRA2 25136  
Anti-Mouse GFRA2 GFRA2 14586  
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More ELISA Kits for GFRA2 Interaction Partners

Human GDNF Family Receptor alpha 2 (GFRA2) interaction partners

  1. GFRA2 variants associated with diabetic neuropathic pain.

  2. The study shows co-localization of RET (show RET ELISA Kits) with GFRA1 (show GFRA1 ELISA Kits) and GFRA2 in myenteric ganglia of the adult human colon.

  3. Cyclic AMP (show APRT ELISA Kits) signalling through PKA but not Epac (show RAPGEF3 ELISA Kits) is essential for neurturin (show NRTN ELISA Kits)-induced biphasic ERK1/2 (show MAPK1/3 ELISA Kits) activation and neurite outgrowths through GFRalpha2 isoforms.

  4. GFRA2 genetic variants, and age, may play a role in susceptibility to tardive dyskinesia.

  5. This study found nominally-significant evidence for interactions between GFRA1 (show GFRA1 ELISA Kits), 2 and 3 associated with schizophrenia and clozapine response, consistent with the locations of these three genes within linkage regions for schizophrenia.

  6. Both GFR (show RAPGEF5 ELISA Kits) alpha2a and GFR (show RAPGEF5 ELISA Kits) alpha2c, but not GFR (show RAPGEF5 ELISA Kits) alpha2b (show ADRA2B ELISA Kits), promote neurite outgrowth in transfected Neuro2A cells.

Mouse (Murine) GDNF Family Receptor alpha 2 (GFRA2) interaction partners

  1. Ret (show RET ELISA Kits) and Gfra2 null mice display comparable early central projection deficits, but Gfra2 null rapidly adapting mechanoreceptors recover later.

  2. STAT3 (show STAT3 ELISA Kits) phosphorylation by neurturin (show NRTN ELISA Kits) was found to be mediated specifically by GFRalpha2c and RET9 (show RET ELISA Kits) isoforms.

  3. Cholinergic innervation of gastric mucosa depends on neurturin (show NRTN ELISA Kits)-GFRalpha2 signalling but is dispensable for gastrin (show GAST ELISA Kits) secretion and for basal and maximal acid output

  4. our data demonstrate that RET (show RET ELISA Kits)/GFRalpha signals are dispensable for thymic T cell development in vivo

  5. Transduction-function role for GFR (show RAPGEF5 ELISA Kits) alpha2/neurturin (show NRTN ELISA Kits) signalling in a specific class of sensory neurons.

  6. The cholinergic subpopulation of sympathetic neurons requires GFR alpha 2 signaling for soma size and for growth or maintenance of target innervation.

  7. Demonstrate a role for GFRalpha2-expressing enteric neurons in the downstream signaling of the glucagon (show GCG ELISA Kits)-like peptides to inhibit GI motility, but not in intestinal growth.

GFRA2 Antigen Profile

Antigen Summary

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GFRA2

  • DKFZP459C0228 protein (DKFZP459C0228) antibody
  • GDNF family receptor alpha 2 (gfra2) antibody
  • glial cell line derived neurotrophic factor family receptor alpha 2a (gfra2a) antibody
  • GDNF family receptor alpha 2 (GFRA2) antibody
  • GDNF family receptor alpha 2 (Gfra2) antibody
  • glial cell line derived neurotrophic factor family receptor alpha 2 (Gfra2) antibody
  • DKFZP459C0228 antibody
  • GDNFRB antibody
  • gfra2 antibody
  • NRTNR-ALPHA antibody
  • NTNRA antibody
  • NTNRALPHA antibody
  • Retl2 antibody
  • TRNR2 antibody

Protein level used designations for GFRA2

DKFZP459C0228 protein , GFR-alpha-2 , GDNF family receptor alpha-2 , GDNF family receptor alpha 2 , glial cell line derived neurotrophic factor family receptor alpha 2 , GFR alpha 2 , GDNF family receptor alpha-2-like , GDNF receptor beta , GDNFR-alpha-2 , GDNFR-beta , GFR-alpha 2 , NTNR-alpha , PI-linked cell-surface accessory protein , RET ligand 2 , TGF-beta-related neurotrophic factor receptor 2 , TRN receptor, GPI-anchored , glial cell line derived neurotrophic factor receptor, beta , neurturin receptor alpha , GDNF receptor alpha-2 , tyrosine kinase receptor ligand 2 , NRTNR-alpha , GFR alpha-2

GENE ID SPECIES
100189713 Pongo abelii
100127717 Xenopus (Silurana) tropicalis
405794 Danio rerio
100475044 Ailuropoda melanoleuca
2675 Homo sapiens
609172 Canis lupus familiaris
514036 Bos taurus
25136 Rattus norvegicus
395993 Gallus gallus
100171804 Pongo abelii
14586 Mus musculus
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