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GDP-mannose 4,6-dehydratase (GMD; EC 184.108.40.206) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. Additionally we are shipping GDP-Mannose 4,6-Dehydratase Proteins (7) and GDP-Mannose 4,6-Dehydratase Kits (2) and many more products for this protein.
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Data indicate three loci associated with primary open-angle glaucoma (POAG) were located upstream of ATP binding cassette transporter 1 (ABCA1 (show ABCA1 Antibodies)), within actin filament associated protein 1 (AFAP1 (show AFAP1 Antibodies)) and within GDP-mannose 46-dehydratase (GMDS).
These data demonstrate involvement of GMDS mutation in the progression of colorectal cancer.
Fx enzyme and GDP-L-Fuc (show FUT8 Antibodies) Tr overexpression in the tumur tissue of colorectal cancer (CRC (show CALR Antibodies)) patients suggests that GDP-L-Fuc (show FUT8 Antibodies) transport to the Golgi apparatus may be an important factor associated with increased alpha(1,6)fucosylation in CRC (show CALR Antibodies).
GMD inhibits tankyrase 1 (show TNKS Antibodies) poly(ADP-ribose) polymerase (show PARP1 Antibodies) activity in vitro, dependent on the GMD tankyrase 1 (show TNKS Antibodies) binding motif. In vivo, depletion of GMD led to degradation of tankyrase 1 (show TNKS Antibodies), dependent on the catalytic PARP (show COL11A2 Antibodies) activity of tankyrase 1 (show TNKS Antibodies).
Results indicate that GMDS regulates the formation of secondary complex II from the primary DISC independent of direct fucosylation of death receptors.
Deficiency of GMDS leads to escape from natural killer cell-mediated tumor surveillance through modulation of TRAIL signaling.
GDP-mannose 4,6-dehydratase (GMD\; EC 220.127.116.11) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).
, GDP-mannose 4,6 dehydratase
, short chain dehydrogenase/reductase family 3E, member 1