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GLE1 RNA Export Mediator Homolog (Yeast) Proteins (GLE1)

GLE1 encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Additionally we are shipping GLE1 RNA Export Mediator Homolog (Yeast) Antibodies (43) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GLE1 2733 Q53GS7
GLE1 362098 Q4KLN4
GLE1 74412 Q8R322
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Top GLE1 RNA Export Mediator Homolog (Yeast) Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Schizosaccharomyces pombe His tag   1 mg Log in to see 56 to 66 Days
$3,356.83
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,033.33
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

GLE1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

Mouse (Murine)

More Proteins for GLE1 RNA Export Mediator Homolog (Yeast) (GLE1) Interaction Partners

Human GLE1 RNA Export Mediator Homolog (Yeast) (GLE1) interaction partners

  1. Restoration of miR (show MLXIP Proteins)-127-3p and miR (show MLXIP Proteins)-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1 (show UBXN11 Proteins), GLE1 and PDIA6 (show PDIA6 Proteins).

  2. We report the identification of the first heterozygous mutations in GLE1 ever found to be associated with amyotrophic lateral sclerosis.

  3. Lethal congenital contracture syndrome 1 and lethal arthrogryposis with anterior horn cell disease are associated with defective Gle1 function during the export of mRNA. [review]

  4. Report documents a requirement for Gle1 self-association during mRNA export and uncover molecular defects underlying a lethal human disease lethal congenital contracture syndrome-1.

  5. Dbp5, Gle1-IP6 (show GPRIN2 Proteins) and Nup159: a working model for mRNP export.

  6. defective zebrafish GLE1 function in human LCCS1 results in both neurogenic and non-neurogenic defects linked to the apoptosis of proliferative organ precursors

  7. The unique carboxyl-terminal 43 amino acid region of the hGle1B isoform mediates binding to the C-terminal non-phenylalanine- glycine region of the nucleoporin hCG1/NPL1.

  8. Mutations in mRNA export mediator GLE1 result in fetal motoneuron disease.

GLE1 RNA Export Mediator Homolog (Yeast) (GLE1) Protein Profile

Protein Summary

This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GLE1

  • CG14749 gene product from transcript CG14749-RA (CG14749)
  • nucleoporin GLE1 (CpipJ_CPIJ014147)
  • nucleoporin GLE1 (SJAG_03847)
  • GLE1 RNA export mediator (GLE1)
  • GLE1 RNA export mediator (Gle1)
  • GLE1 RNA export mediator (yeast) (Gle1)
  • GLE1 RNA export mediator homolog (yeast) (GLE1)
  • 4933405K21Rik protein
  • AA553313 protein
  • Dmel\\CG14749 protein
  • GLE1 protein
  • Gle1l protein
  • hGLE1 protein
  • LCCS protein
  • LCCS1 protein

Protein level used designations for GLE1

CG14749-PA , nucleoporin GLE1 , GLE1 RNA export mediator homolog , GLE1-like protein , GLE1-like, RNA export mediator , GLE1 RNA export mediator-like (yeast

GENE ID SPECIES
35849 Drosophila melanogaster
6047573 Culex quinquefasciatus
7050485 Schizosaccharomyces japonicus yFS275
417212 Gallus gallus
2733 Homo sapiens
362098 Rattus norvegicus
74412 Mus musculus
480704 Canis lupus familiaris
540982 Bos taurus
100172586 Pongo abelii
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