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GLIS Family Zinc Finger 2 Proteins (GLIS2)

GLIS2 is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. Additionally we are shipping GLIS2 Antibodies (26) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GLIS2 84662 Q9BZE0
GLIS2 83396 Q8VDL9
Rat GLIS2 GLIS2 302946  
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Top GLIS2 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$3,393.50
Details

GLIS2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for GLIS Family Zinc Finger 2 (GLIS2) Interaction Partners

Human GLIS Family Zinc Finger 2 (GLIS2) interaction partners

  1. Glis2/NPHP7 is extensively modified by post-translational modifications

  2. Findings are unprecedented and indicate that the DHH (show DHH Proteins)-RHEBL1 (show RHEBL1 Proteins) fusion transcript is a novel recurrent feature in the changing landscape of CBFA2T3 (show CBFA2T3 Proteins)-GLIS2-positive childhood AML (show RUNX1 Proteins).

  3. BBS11 (show TRIM32 Proteins) promotes accumulation of NPHP7, changing the properties of NPHP7. TRIM32 (show TRIM32 Proteins) Modulates the Transcriptional Activities of Glis2

  4. Recessive mutation in GLIS2 gene is associated with Caroli disease.

  5. Identification of a cryptic chromosome 16 inversion (inv (show INVS Proteins)(16)(p13.3q24.3)) in 27% of pediatric acute megakaryoblastic leukemia cases, which encodes a CBFA2T3 (show CBFA2T3 Proteins)-GLIS2 fusion protein.

  6. Glis2 can function as a transcriptional activator and that post-translational modification within its DNA-binding domain can regulate its transcriptional activity

  7. Characterization of Glis2, a novel gene encoding a Gli (show GLI1 Proteins)-related, Kruppel-like transcription factor (show KLF4 Proteins) with transactivation and repressor functions

  8. Glis2 functions as a negative modulator of beta-catenin (show CTNNB1 Proteins)/TCF (show HNF4A Proteins)-mediated transcription.

  9. identification of Gli-similar 2 (Glis2) as a novel binding protein for p120 catenin (show CTNND1 Proteins)

  10. Study identified Glis2 as a transcription factor mutated in Nephronophthisis and demonstrate its essential role for the maintenance of renal tissue architecture through prevention of apoptosis and fibrosis.

Mouse (Murine) GLIS Family Zinc Finger 2 (GLIS2) interaction partners

  1. Glis2 can function as a transcriptional activator and that post-translational modification within its DNA-binding domain can regulate its transcriptional activity

  2. Characterization of Glis2, a novel gene encoding a Gli (show GLI1 Proteins)-related, Kruppel-like transcription factor (show KLF4 Proteins) with transactivation and repressor functions

  3. Deficiency in Glis2 expression leads to tubular atrophy & progressive fibrosis, similar to nephronophthisis, that ultimately results in renal failure. Glis2 plays a critical role in the maintenance of normal kidney architecture and functions.

GLIS2 Protein Profile

Protein Summary

This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys.

Gene names and symbols associated with GLIS2

  • Kruppel-like zinc finger protein GLIS2 (glis2b)
  • GLIS family zinc finger 2 (GLIS2)
  • GLIS family zinc finger 2 (Glis2)
  • GLIS family zinc finger 2 (glis2)
  • Gli5 protein
  • glis2a protein
  • glis2b protein
  • Klf16 protein
  • Nkl protein
  • nkl-A protein
  • nphp7 protein
  • xNKLb protein

Protein level used designations for GLIS2

Kruppel-like zinc finger protein GLIS2 , Gli-Kruppel zinc-finger protein NKL , GLI-similar 2 , GLI-similar protein 2 , nephrocystin-7 , neuronal Krueppel-like protein , zinc finger protein GLIS2 , GLI-Kruppel family member GLI5 , Kruppel-like factor 16 (neuronal) , zinc finger protein GLI5 , GLIS family zinc finger 2

GENE ID SPECIES
373773 Xenopus laevis
84662 Homo sapiens
490028 Canis lupus familiaris
83396 Mus musculus
302946 Rattus norvegicus
398220 Xenopus laevis
374023 Gallus gallus
527935 Bos taurus
100624334 Sus scrofa
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