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GM2A encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Additionally we are shipping GM2 Ganglioside Activator Antibodies (136) and GM2 Ganglioside Activator Kits (5) and many more products for this protein.
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Human GM2A Protein expressed in Baculovirus infected Insect Cells - ABIN2005609
Wright, Zhao, Rastinejad: Structural analysis of lipid complexes of GM2-activator protein. in Journal of molecular biology 2003
Mobilization of membrane lipids by GM2AP was also inhibited in the presence of cholesterol or SM, as revealed by surface plasmon resonance studies
Gene polymorphisms of MD2 (show LY96 Proteins) and GM2A were associated with the occurrence or severity of neonatal necrotizing enterocolitis.
In vitro assays with the isolated H1 or H2 homodimers (beta-alpha hybrid construct of beta-hexosaminidase A subunits) confirmed that neither was capable of human GM2AP-dependent hydrolysis of GM2 (show CYB5D2 Proteins) ganglioside.
impact of GM2AP on glucose metabolism
Treatment of meniscal explants with IL-1RA (show IL1RN Proteins) inhibited the expression of many catabolic genes following a single bout of high dynamic strain.
these results provide novel insights into the physiological functions of GM2AP in obesity.
GM2 (show CYB5D2 Proteins) activator protein exerts strong and broad inhibitory effects on the hydrolysis of phospholipids carried out by plant and microbial phospholipases D
Two new structures of GM2-AP with bound lipids, showing two different lipid-binding modes within the apolar pocket
elucidation of mode of action on gangioside GM2 (show CYB5D2 Proteins)
alpha-subunit loop structure is required for GM2 activator protein binding by beta-hexosaminidase A
The trafficking of prosaposin (show PSAP Proteins) and GM2 (show CYB5D2 Proteins) activator protein to the lysosome in sertoli cells is dependent on sortilin (show SORT1 Proteins).
This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants.
GM2 ganglioside activator protein
, ganglioside GM2 activator
, GM2 ganglioside activator
, GM2 activator protein
, cerebroside sulfate activator protein
, shingolipid activator protein 3
, sphingolipid activator protein 3