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GM2 Ganglioside Activator Proteins (GM2A)

GM2A encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Additionally we are shipping GM2 Ganglioside Activator Antibodies (136) and GM2 Ganglioside Activator Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat GM2A GM2A 282838  
GM2A 2760 P17900
GM2A 14667 Q60648
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Top GM2 Ganglioside Activator Proteins at antibodies-online.com

Showing 9 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human GST tag GM2 Ganglioside Activator (GM2A) (AA 32-193), (full length) protein (GST tag) 1 mg Log in to see 56 to 66 Days
$1,842.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$2,383.33
Details
HOST_Human Human His tag   10 μg Log in to see 5 Days
$203.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details

GM2A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

Top referenced GM2 Ganglioside Activator Proteins

  1. Human GM2A Protein expressed in Baculovirus infected Insect Cells - ABIN2005609 : Wright, Zhao, Rastinejad: Structural analysis of lipid complexes of GM2-activator protein. in Journal of molecular biology 2003 (PubMed)

More Proteins for GM2 Ganglioside Activator (GM2A) Interaction Partners

Human GM2 Ganglioside Activator (GM2A) interaction partners

  1. Mobilization of membrane lipids by GM2AP was also inhibited in the presence of cholesterol or SM, as revealed by surface plasmon resonance studies

  2. Gene polymorphisms of MD2 (show LY96 Proteins) and GM2A were associated with the occurrence or severity of neonatal necrotizing enterocolitis.

  3. In vitro assays with the isolated H1 or H2 homodimers (beta-alpha hybrid construct of beta-hexosaminidase A subunits) confirmed that neither was capable of human GM2AP-dependent hydrolysis of GM2 (show CYB5D2 Proteins) ganglioside.

  4. impact of GM2AP on glucose metabolism

  5. Treatment of meniscal explants with IL-1RA (show IL1RN Proteins) inhibited the expression of many catabolic genes following a single bout of high dynamic strain.

  6. these results provide novel insights into the physiological functions of GM2AP in obesity.

  7. GM2 (show CYB5D2 Proteins) activator protein exerts strong and broad inhibitory effects on the hydrolysis of phospholipids carried out by plant and microbial phospholipases D

  8. Two new structures of GM2-AP with bound lipids, showing two different lipid-binding modes within the apolar pocket

  9. elucidation of mode of action on gangioside GM2 (show CYB5D2 Proteins)

  10. alpha-subunit loop structure is required for GM2 activator protein binding by beta-hexosaminidase A

Mouse (Murine) GM2 Ganglioside Activator (GM2A) interaction partners

  1. impact of GM2AP on glucose metabolism

  2. these results provide novel insights into the physiological functions of GM2AP in obesity.

  3. GM2 (show CYB5D2 Proteins) activator protein exerts strong and broad inhibitory effects on the hydrolysis of phospholipids carried out by plant and microbial phospholipases D

  4. The trafficking of prosaposin (show PSAP Proteins) and GM2 (show CYB5D2 Proteins) activator protein to the lysosome in sertoli cells is dependent on sortilin (show SORT1 Proteins).

GM2 Ganglioside Activator (GM2A) Protein Profile

Protein Summary

This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with GM2A

  • GM2 ganglioside activator (Gm2a)
  • GM2 ganglioside activator (GM2A)
  • GM2 ganglioside activator (gm2a)
  • GM2 ganglioside activator protein (Gm2a)
  • AA408702 protein
  • AW215435 protein
  • fb96e04 protein
  • fb96e10 protein
  • GM2-AP protein
  • GM2A protein
  • MGC84154 protein
  • SAP-3 protein
  • wu:fb96e04 protein
  • wu:fb96e10 protein
  • zgc:110188 protein

Protein level used designations for GM2A

GM2 ganglioside activator protein , ganglioside GM2 activator , GM2 ganglioside activator , GM2 activator protein , cerebroside sulfate activator protein , shingolipid activator protein 3 , sphingolipid activator protein 3

GENE ID SPECIES
282838 Rattus norvegicus
471705 Pan troglodytes
479324 Canis lupus familiaris
504524 Bos taurus
548463 Xenopus (Silurana) tropicalis
550529 Danio rerio
779153 Xenopus laevis
100174922 Felis catus
2760 Homo sapiens
14667 Mus musculus
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