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anti-GNAS Complex Locus (GNAS) Antibodies

This locus has a highly complex imprinted expression pattern. Additionally we are shipping GNAS Proteins (16) and GNAS Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GNAS 14683 Q6R0H6,Q6R0H7,P63094,Q9Z0F1
GNAS 2778 P84996,Q5JWF2,P63092,O95467
GNAS 24896 P63095,Q792G6
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Top anti-GNAS Antibodies at antibodies-online.com

Showing 10 out of 142 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of GNAS Antibody (Center) in Ramos cell line lysates (35 µg/lane). GNAS (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-GNAS Antibody Titration: 2.5ug/mlPositive Control: Jurkat cell lysate WB Suggested Anti-GNAS  Antibody Titration: 2.5 µg/mL  Positive Control: Jurkat cell lysate  There is BioGPS gene expression data showing that GNAS is expressed in Jurkat 100 μL Log in to see 2 to 3 Days
$229.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-GNAS Antibody Titration: 2.5ug/mlPositive Control: Jurkat cell lysate WB Suggested Anti-GNAS  Antibody Titration: 1 µg/mL  Positive Control: HepG2 lysate  There is BioGPS gene expression data showing that GNAS is expressed in HepG2 100 μL Log in to see 2 to 3 Days
$229.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-GNAS Antibody Titration: 1.25ug/mlPositive Control: Jurkat cell lysate Sample Type: Nthy-ori cell lysate (50ug)Primary Dilution: 1:1000Secondary Antibody: anti-rabbit HRPSecondary Dilution: 1:2000Image Submitted By: Anonymous 100 μL Log in to see 2 to 3 Days
$229.00
Details
Cow Goat Un-conjugated EIA, WB AP20123PU-N GNAS antibody staining of Jurkat lysate at 1 µg/ml (RIPA buffer, 35 µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. AP20123PU-N GNAS antibody staining of Mouse brain (Lane A) and Rat brain (Lane B) at 0.1 µg/ml (35µg protein in RIPA buffer). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of GNAS Antibody (Center) (ABIN390851) in Ramos cell line lysates (35 µg/lane). GNAS (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of GNAS (arrow) using rabbit polyclonal GNAS Antibody (C-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the GNAS gene. GNAS Antibody (C-term)  western blot analysis in 293,NCI-H292 cell line lysates (35ug/lane).This demonstrates the GNAS antibody detected the GNAS protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated IHC, WB 100 μg Log in to see 8 to 10 Days
$493.17
Details

GNAS Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)
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Human , , , ,
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Rat (Rattus)
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Top referenced anti-GNAS Antibodies

  1. Cow (Bovine) Polyclonal GNAS Primary Antibody for IHC, WB - ABIN2775542 : Bagchi, Wu, French, Kim, Moniri, Daaka: Androgens transduce the G alphas-mediated activation of protein kinase A in prostate cells. in Cancer research 2008 (PubMed)
    Show all 3 references for ABIN2775542

  2. Cow (Bovine) Polyclonal GNAS Primary Antibody for EIA, WB - ABIN498036 : Nishihara, Amino, Maekawa, Yoshida, Ito, Kubota, Fukata, Miyauchi: Prevalence of TSH receptor and Gsalpha mutations in 45 autonomously functioning thyroid nodules in Japan. in Endocrine journal 2009 (PubMed)

  3. Chicken Polyclonal GNAS Primary Antibody for WB - ABIN2776982 : Linglart, Mahon, Kerachian, Berlach, Hendy, Jüppner, Bastepe: Coding GNAS mutations leading to hormone resistance impair in vitro agonist- and cholera toxin-induced adenosine cyclic 3',5'-monophosphate formation mediated by human XLalphas. in Endocrinology 2006 (PubMed)

More Antibodies against GNAS Interaction Partners

Pig (Porcine) GNAS Complex Locus (GNAS) interaction partners

  1. Target RNA interference of GNAS in porcine fibroblast cells leads to lower mRNA expression of Bcl-2 (show BCL2 Antibodies), Fas (show FAS Antibodies), and Caspase-3 (show CASP3 Antibodies), which are recognized as apoptosis related markers.

  2. study did not find any significant associations for polymorphisms in insulin (show INS Antibodies)-like grwoth factor 2, GTP Binding Protein (show RND1 Antibodies) alpha Subunits, Gs and melanocortin receptor 4 (show MC4R Antibodies) genes with reproductive traits of Polish Landrace and Large White pigs

  3. Genetic inhibition of GNAS protein in the atrioventricular node reduced heart rate and prevented atrial fibrillation-associated reduction of cardiac function in a porcine model.

  4. Imprinting analysis showed that NESP55 is maternally expressed in young and adult pigs.

  5. Review article on the human GNAS complex locus.

Mouse (Murine) GNAS Complex Locus (GNAS) interaction partners

  1. demonstrate that the ability of an MC4R (show MC4R Antibodies) agonist delivered to PVN to inhibit food intake is lost in mice lacking G(q/11)alpha in the paraventricular nucleus of the hypothalamus but not in animals deficient for G(s)alpha

  2. Gsalpha is required in proximal tubules for suppressing renal vitamin D 24-hydroxylase (show CYP24A1 Antibodies) mRNA levels and for maintaining normal serum 1,25(OH)2D.

  3. Ventromedial hypothalamic Gsalpha/cyclic AMP (show TMPRSS5 Antibodies) signaling regulates glucose homeostasis and alters leptin (show LEP Antibodies) sensitivity in mice, particularly in the setting of excess caloric intake.

  4. findings suggest that XLalphas enhances Gq/11 signaling to mediate the renal actions of PTH (show PTH Antibodies) during early postnatal development.

  5. acidosis in inflamed tissues may be a decisive factor to regulate switching of PKA and PKCepsilon dependence via proton-sensing G-protein-coupled receptors.

  6. a novel role of Galphas in control of neural progenitor asymmetric cell division via suppressing Numb (show NUMB Antibodies) mediated Notch (show NOTCH1 Antibodies) signaling inhibition

  7. This study highlights an important tumour suppressive function of Galphas-PKA, limiting the proliferation of epithelial stem cells and maintaining proper hair follicle homeostasis.

  8. targeted ablation of Gs alpha in early osteoblast precursors, but not in differentiated osteocytes, results in a dramatic increase in bone marrow adipocytes.

  9. a paternally inherited Gnas cluster showing ectopic expression of Nesp is "maternalised" in terms of Gnasxl and Gnas expression.

  10. Altered gene dosages for Galphas and alpha- NAC (show NACa1 Antibodies) in compound heterozygous mice result in reduced bone mass, increased numbers of osteocytes, and enhanced expression of Sost (show SOST Antibodies).

Human GNAS Complex Locus (GNAS) interaction partners

  1. GNAS mutations are highly specific for fibrous dysplasia and occur rarely, if ever, in parosteal and other low-grade osteosarcomas.

  2. functional evidence that G-protein coupling to the beta2AR (show ADRB2 Antibodies) stabilizes a 'closed' receptor conformation characterized by restricted access to and egress from the hormone-binding site

  3. imprinting of GNAS is the determining factor for the variability of the phenotype.

  4. Report a mutation spectrum that includes GNAS, KRAS and TP53 (show TP53 Antibodies) may be shared by mucinous neoplasms of the appendix.

  5. Known activating mutations in GNAS were detected in five cases (16.1%) of GH-secreting pituitary adenomas.

  6. paternal duplication of the chromosomal region comprising the GNAS locus appears to be a fairly common cause of sporadic Pseudohypoparathyroidism type Ib that is likely to occur with equal frequency in Caucasians and Asians.

  7. GNAS-based mutations are associated with Progressive osseous heteroplasia with Albright hereditary osteodystrophy.

  8. GNAS mutation affecting codon 201 is rare in most human tumors.

  9. Progressive osseous heteroplasia is caused by a heterozygous GNAS inactivating mutation and has been associated with paternal inheritance--{REVIEW}

  10. he GNAS locus on chromosome 20q13.3 gives rise to several, alternatively spliced transcripts, including the alphasubunit of the stimulatory G protein

Cow (Bovine) GNAS Complex Locus (GNAS) interaction partners

  1. application of peptide amide hydrogen-deuterium exchange mass spectrometry to probe changes in the structure of the heterotrimeric bovine G protein, Gs on formation of a complex with agonist-bound human beta(2) adrenergic receptor (show ADRB2 Antibodies)

  2. crystal structure of the active state ternary complex composed of agonist-occupied monomeric beta2 adrenergic receptor (show ADRB2 Antibodies) and nucleotide-free Gs heterotrimer

  3. the results presented here indicate an important role for the imprinted GNAS cluster in underlying complex

  4. a nucleotide-free state of Galphas is induced by Cu2+ and Zn2+

Xenopus laevis GNAS Complex Locus (GNAS) interaction partners

  1. Regulation of G-protein signaling via Gnas is required to regulate proximal tubular growth in the Xenopus pronephros.

GNAS Antigen Profile

Protein Summary

This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.

Gene names and symbols associated with GNAS

  • guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 2 (gnal2) antibody
  • GNAS complex locus (GNAS) antibody
  • GNAS complex locus (gnas) antibody
  • GNAS complex locus (LOC100346323) antibody
  • GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus (Gnas) antibody
  • GNAS complex locus (Gnas) antibody
  • 5530400H20Rik antibody
  • A930027G11Rik antibody
  • AHO antibody
  • C20orf45 antibody
  • C130027O20Rik antibody
  • G-alpha-S antibody
  • Galphas antibody
  • gnal antibody
  • GNAS antibody
  • gnas-a antibody
  • GNAS1 antibody
  • Gnasxl antibody
  • Gnpas antibody
  • GPSA antibody
  • GSA antibody
  • GSP antibody
  • NESP antibody
  • Nesp55 antibody
  • Nespl antibody
  • Oed-Sml antibody
  • Oedsml antibody
  • P1 antibody
  • P2 antibody
  • P3 antibody
  • PHP1A antibody
  • PHP1B antibody
  • PHP1C antibody
  • POH antibody
  • PORGSA1 antibody
  • zgc:92392 antibody

Protein level used designations for GNAS

Galpha olf1 , Golf2 , guanine nucleotide-binding protein G(olf) subunit alpha , guanine nucleotide binding protein, alpha stimulating activity polypeptide 1 , GNAS complex locus , guanine nucleotide binding protein, alpha stimulating, olfactory type , guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like , Gs alpha subunit , adenylate cyclase-stimulating G alpha protein , alternative gene product encoded by XL-exon , extra large alphas protein , guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas , neuroendocrine secretory protein 55 , protein ALEX , stimulatory G-protein alpha subunit , guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1 , guanine nucleotide regulatory protein , neuroendocrine secretory protein , secretogranin VI , GTP-binding regulatory protein alpha subunit exon 1 , guanine nucleotide-binding protein G(s) subunit alpha , stimulatory GTP binding protein , alpha-stimulatory subunit of GTP-binding protein , guanine nucleotide-binding protein, alpha-stimulating activity polypeptide 1 , guanine nucleotide-binding protein G(s) subunit alpha isoforms , G-alpha-8 , GNAS , GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus , guanine nucleotide binding protein alpha s , guanine nucleotide-binding protein G-s, alpha subunit

GENE ID SPECIES
407724 Danio rerio
469986 Pan troglodytes
694289 Macaca mulatta
100151807 Sus scrofa
407931 Xenopus (Silurana) tropicalis
100021523 Monodelphis domestica
100346323 Oryctolagus cuniculus
100442753 Pongo abelii
100604281 Nomascus leucogenys
14683 Mus musculus
2778 Homo sapiens
403943 Canis lupus familiaris
100049657 Sus scrofa
281793 Bos taurus
24896 Rattus norvegicus
394414 Xenopus laevis
419313 Gallus gallus
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