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GNAS Complex Locus Proteins (GNAS)

This locus has a highly complex imprinted expression pattern. Additionally we are shipping GNAS Antibodies (142) and GNAS Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GNAS 14683 Q6R0H6,Q6R0H7,P63094,Q9Z0F1
GNAS 2778 P84996,Q5JWF2,P63092,O95467
GNAS 24896 P63095,Q792G6
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Top GNAS Proteins at antibodies-online.com

Showing 6 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,469.50
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,517.17
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

GNAS Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,
Rat (Rattus)

More Proteins for GNAS Complex Locus (GNAS) Interaction Partners

Pig (Porcine) GNAS Complex Locus (GNAS) interaction partners

  1. Target RNA interference of GNAS in porcine fibroblast cells leads to lower mRNA expression of Bcl-2 (show BCL2 Proteins), Fas (show FAS Proteins), and Caspase-3 (show CASP3 Proteins), which are recognized as apoptosis related markers.

  2. study did not find any significant associations for polymorphisms in insulin (show INS Proteins)-like grwoth factor 2, GTP Binding Protein (show RND1 Proteins) alpha Subunits, Gs and melanocortin receptor 4 (show MC4R Proteins) genes with reproductive traits of Polish Landrace and Large White pigs

  3. Genetic inhibition of GNAS protein in the atrioventricular node reduced heart rate and prevented atrial fibrillation-associated reduction of cardiac function in a porcine model.

  4. Imprinting analysis showed that NESP55 is maternally expressed in young and adult pigs.

  5. Review article on the human GNAS complex locus.

Mouse (Murine) GNAS Complex Locus (GNAS) interaction partners

  1. Galphas depletion blocks the S1PR1 (show S1PR1 Proteins)-activation induced VE-cadherin (show CDH5 Proteins) stabilization at junctions.

  2. demonstrate that the ability of an MC4R (show MC4R Proteins) agonist delivered to PVN to inhibit food intake is lost in mice lacking G(q/11)alpha in the paraventricular nucleus of the hypothalamus but not in animals deficient for G(s)alpha

  3. Gsalpha is required in proximal tubules for suppressing renal vitamin D 24-hydroxylase (show CYP24A1 Proteins) mRNA levels and for maintaining normal serum 1,25(OH)2D.

  4. Ventromedial hypothalamic Gsalpha/cyclic AMP (show TMPRSS5 Proteins) signaling regulates glucose homeostasis and alters leptin (show LEP Proteins) sensitivity in mice, particularly in the setting of excess caloric intake.

  5. findings suggest that XLalphas enhances Gq/11 signaling to mediate the renal actions of PTH (show PTH Proteins) during early postnatal development.

  6. acidosis in inflamed tissues may be a decisive factor to regulate switching of PKA and PKCepsilon dependence via proton-sensing G-protein-coupled receptors.

  7. a novel role of Galphas in control of neural progenitor asymmetric cell division via suppressing Numb (show NUMB Proteins) mediated Notch (show NOTCH1 Proteins) signaling inhibition

  8. This study highlights an important tumour suppressive function of Galphas-PKA, limiting the proliferation of epithelial stem cells and maintaining proper hair follicle homeostasis.

  9. targeted ablation of Gs alpha in early osteoblast precursors, but not in differentiated osteocytes, results in a dramatic increase in bone marrow adipocytes.

  10. a paternally inherited Gnas cluster showing ectopic expression of Nesp is "maternalised" in terms of Gnasxl and Gnas expression.

Human GNAS Complex Locus (GNAS) interaction partners

  1. GNAS mutations are highly specific for fibrous dysplasia and occur rarely, if ever, in parosteal and other low-grade osteosarcomas.

  2. functional evidence that G-protein coupling to the beta2AR (show ADRB2 Proteins) stabilizes a 'closed' receptor conformation characterized by restricted access to and egress from the hormone-binding site

  3. imprinting of GNAS is the determining factor for the variability of the phenotype.

  4. Report a mutation spectrum that includes GNAS, KRAS and TP53 (show TP53 Proteins) may be shared by mucinous neoplasms of the appendix.

  5. Known activating mutations in GNAS were detected in five cases (16.1%) of GH-secreting pituitary adenomas.

  6. paternal duplication of the chromosomal region comprising the GNAS locus appears to be a fairly common cause of sporadic Pseudohypoparathyroidism type Ib that is likely to occur with equal frequency in Caucasians and Asians.

  7. GNAS-based mutations are associated with Progressive osseous heteroplasia with Albright hereditary osteodystrophy.

  8. GNAS mutation affecting codon 201 is rare in most human tumors.

  9. Progressive osseous heteroplasia is caused by a heterozygous GNAS inactivating mutation and has been associated with paternal inheritance--{REVIEW}

  10. he GNAS locus on chromosome 20q13.3 gives rise to several, alternatively spliced transcripts, including the alphasubunit of the stimulatory G protein

Cow (Bovine) GNAS Complex Locus (GNAS) interaction partners

  1. application of peptide amide hydrogen-deuterium exchange mass spectrometry to probe changes in the structure of the heterotrimeric bovine G protein, Gs on formation of a complex with agonist-bound human beta(2) adrenergic receptor (show ADRB2 Proteins)

  2. crystal structure of the active state ternary complex composed of agonist-occupied monomeric beta2 adrenergic receptor (show ADRB2 Proteins) and nucleotide-free Gs heterotrimer

  3. the results presented here indicate an important role for the imprinted GNAS cluster in underlying complex

  4. a nucleotide-free state of Galphas is induced by Cu2+ and Zn2+

Xenopus laevis GNAS Complex Locus (GNAS) interaction partners

  1. Regulation of G-protein signaling via Gnas is required to regulate proximal tubular growth in the Xenopus pronephros.

GNAS Protein Profile

Protein Summary

This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.

Gene names and symbols associated with GNAS Complex Locus Proteins (GNAS)

  • guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 2 (gnal2)
  • GNAS complex locus (GNAS)
  • GNAS complex locus (gnas)
  • GNAS complex locus (LOC100346323)
  • GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus (Gnas)
  • GNAS complex locus (Gnas)
  • 5530400H20Rik protein
  • A930027G11Rik protein
  • AHO protein
  • C20orf45 protein
  • C130027O20Rik protein
  • G-alpha-S protein
  • Galphas protein
  • gnal protein
  • GNAS protein
  • gnas-a protein
  • GNAS1 protein
  • Gnasxl protein
  • Gnpas protein
  • GPSA protein
  • GSA protein
  • GSP protein
  • NESP protein
  • Nesp55 protein
  • Nespl protein
  • Oed-Sml protein
  • Oedsml protein
  • P1 protein
  • P2 protein
  • P3 protein
  • PHP1A protein
  • PHP1B protein
  • PHP1C protein
  • POH protein
  • PORGSA1 protein
  • zgc:92392 protein

Protein level used designations for GNAS Complex Locus Proteins (GNAS)

Galpha olf1 , Golf2 , guanine nucleotide-binding protein G(olf) subunit alpha , guanine nucleotide binding protein, alpha stimulating activity polypeptide 1 , GNAS complex locus , guanine nucleotide binding protein, alpha stimulating, olfactory type , guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like , Gs alpha subunit , adenylate cyclase-stimulating G alpha protein , alternative gene product encoded by XL-exon , extra large alphas protein , guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas , neuroendocrine secretory protein 55 , protein ALEX , stimulatory G-protein alpha subunit , guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1 , guanine nucleotide regulatory protein , neuroendocrine secretory protein , secretogranin VI , GTP-binding regulatory protein alpha subunit exon 1 , guanine nucleotide-binding protein G(s) subunit alpha , stimulatory GTP binding protein , alpha-stimulatory subunit of GTP-binding protein , guanine nucleotide-binding protein, alpha-stimulating activity polypeptide 1 , guanine nucleotide-binding protein G(s) subunit alpha isoforms , G-alpha-8 , GNAS , GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus , guanine nucleotide binding protein alpha s , guanine nucleotide-binding protein G-s, alpha subunit

GENE ID SPECIES
407724 Danio rerio
469986 Pan troglodytes
694289 Macaca mulatta
100151807 Sus scrofa
407931 Xenopus (Silurana) tropicalis
100021523 Monodelphis domestica
100346323 Oryctolagus cuniculus
100442753 Pongo abelii
100604281 Nomascus leucogenys
14683 Mus musculus
2778 Homo sapiens
403943 Canis lupus familiaris
100049657 Sus scrofa
281793 Bos taurus
24896 Rattus norvegicus
394414 Xenopus laevis
419313 Gallus gallus
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