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GRAP encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. Additionally we are shipping GRAP Antibodies (62) and GRAP Kits (3) and many more products for this protein.
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Grb2-related adaptor protein (GRAP) was up-regulated in kidney tubules from fibrotic kidneys from diabetic patients, and subsequently confirmed a (show TGFB1 Proteins)s a novel component of TGF-beta signaling in cultured human renal tubule cells.
Results suggest that the GRAP gene might have a role in the pathogenesis of Sjogren's syndrome.
Our findings define a pathway involving CD28 (show CD28 Proteins) binding to Grb-2 (show GRB2 Proteins) and its co-operativity with Vav1 (show VAV1 Proteins) in the regulation of T-cell co-stimulation.
Grb2-related adaptor protein (GRAP) was up-regulated in kidney tubules from diabetic mice, indicating a potential novel role for GRAP in TGF-beta (show TGFB1 Proteins)-induced tubule injury in diabetic kidney disease.
Data suggest that Grap, unlike Grb2 (show GRB2 Proteins), acts as a negative regulator of TCR-stimulated intracellular signaling by downregulating signal relay through the Ras/Erk (show EPHB2 Proteins) pathway.
FcgammaRIIB docking site for the SH2 domain-containing adapters Grb2 (show GRB2 Proteins) and Grap
This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.
GRB2-related adaptor protein
, GRB2-related adapter protein
, growth factor receptor-bound protein 2-related adaptor protein