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Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. Additionally we are shipping GSX2 Antibodies (30) and many more products for this protein.
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we generated a transgenic mouse line driving Cre and EGFP expression with two putative cis (show CISH Proteins)-regulatory modules upstream of the homeobox (show PRRX1 Proteins) gene Gsx2 , a critical gene for establishing lateral ganglionic eminence (LGE) identity.
homeodomain transcription factor Gsx2 plays a crucial role in the region-specific control of adult neural stem cells in both persistent and injury-induced neurogenesis
despite their redundant properties, Gsx1 and -2 have distinct interactions with Dlx1 and -2
high levels of Gsx2 suppress dendrocyte precursor cells specification in lateral ganglionic eminence progenitors; its downregulation is required for the transition from neurogenesis to oligodendrogenesis
Results show that Gsx1 (show GSX1 Proteins) and Gsx2 differentially regulate the maturation of LGE progenitors.
repression of Ngn1 (show NEUROG1 Proteins) by Gsh2 promotes the differentiation of dI3 interneurons
By analysis of Gsh2 in mutant mice, it can be demonstrated that Gsh2 along with Pax6 (show PAX6 Proteins) are directly required for major aspects of pallial-subpallial boundary progenitor cell specification.
Data show that in the Gsx2 mutants Gsx1 (show GSX1 Proteins) is expressed in only a subset of the ventral telencephalic progenitors that normally express Gsx2.
4q12 translocations with GSX2 expression identify a CD7 (show CDK7 Proteins)(+) acute myeloid leukaemia subset.
Gsx2 negatively regulates neurogenesis from postnatal progenitor cells.
Transgenic mice lacking microRNAs miR (show MLXIP Proteins)-9-2 and miR (show MLXIP Proteins)-9-3 exhibit multiple defects of telencephalic structures which may be brought about by dysregulation of Foxg1 (show FOXG1 Proteins), Nr2e1 (show NR2E1 Proteins), Gsh2, and Meis2 (show MEIS2 Proteins) expression.
ectopically expressed in myeloid leukemic cells with t(4;12)(q11-q12;p13), suggesting that expression of GSH2 was deregulated by the translocation, indicating a variant leukemogenic mechanism for translocations involving the 5' end of ETV6 (show ETV6 Proteins)
Gsx2 specifies striatal projection neuron and olfactory bulb interneuron identity at distinct time points during neurogenesis in transgenic mice.
Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency.
genomic screened homeo box 2
, homeobox protein GSH-2
, genomic screened homeo box 2 protein
, GS homeobox 2
, GS homeobox 2-like
, genomic-screened homeobox 2