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The protein encoded by GEM belongs to the RAD/GEM family of GTP-binding proteins. Additionally we are shipping GEM Antibodies (60) and GEM Kits (2) and many more products for this protein.
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Rad, Gem and Rem (show REM1 Proteins) all reduce depolarization-dependent Ca2 (show CA2 Proteins)+ entry in developing myotubes.
These results suggest that Gem plays an important role in normal beta-cell function by regulation of calcium signalling.
Mechanism of the inhibition of calcium channel activity by Gem.
docking of the RGK protein to the nucleotide-kinase domain of the Cavbeta subunit is reminiscent of the binding of GMP (show NT5C2 Proteins) to guanylate kinase (show GUK1 Proteins)
Results identify specific nuclear localization signals (NLS (show ALDH1A2 Proteins)) in Kir/Gem that are both required and sufficient for nuclear transport.
Down regulation of Gem expression was involved in the pathogenesis of hepatocellular carcinoma (HCC (show FAM126A Proteins)), and it might be a favorable independent prognostic parameter for HCC (show FAM126A Proteins).
These findings demonstrate a new role of Gem/Gmip/RhoA signaling in cortical actin regulation during early mitotic stages.
Gem is involved both in T-cell spontaneous cell migration as well as chemotaxis and plays an important role in cell-to-cell HTLV-1 viral transmission.
Data show a mechanism by which GTPase Gem contributes to the mitotic progression by maintaining correct spindle length through the kinesin Kif9.
Gem contains two candidate inhibitory sites, each capable of producing full inhibition of P/Q-type Ca(2 (show CA2 Proteins)+) channels.
GEM plays a key role during C. pneumoniae entry into human cells.
We discuss the structural and functional properties of RGK proteins and highlight recent work addressing the mechanism of Gem regulation by calmodulin (show CALM1 Proteins) and 14-3-3 (show YWHAQ Proteins).
crystallographic structure and biochemical characterization indicate that Gem G-domain markedly prefers GDP over GTP (show AK3 Proteins)
Gem is a bona fide GTPase (show RACGAP1 Proteins) that exhibits striking structural and biochemical features that should impact its regulation and cellular activities
The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.
Ras-related associated with diabetes
, GTP binding protein overexpressed in skeletal muscle
, GTP binding protein gene overexpressed in skeletal muscle
, GTP-binding protein GEM
, GTP-binding mitogen-induced T-cell protein
, RAS-like protein KIR
, GTP binding protein (gene overexpressed in skeletal muscle)
, Gem GTPase
, GTP-binding protein overexpressed in skeletal muscle
, kinase-inducible Ras-like protein