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anti-GTP Cyclohydrolase 1 (GCH1) Antibodies

GCH1 encodes a member of the GTP cyclohydrolase family. Additionally we are shipping GTP Cyclohydrolase 1 Proteins (12) and GTP Cyclohydrolase 1 Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GCH1 2643 P30793
GCH1 14528 Q05915
GCH1 29244 P22288
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Top anti-GTP Cyclohydrolase 1 Antibodies at antibodies-online.com

Showing 10 out of 78 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated WB GCH1 monoclonal antibody (M01), clone 4A12 Western Blot analysis of GC... 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated IP, IHC, ELISA, WB 0.1 mg Log in to see 2 to 6 Days
$359.70
Details
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged GCH1 is approximately 0.1 n... 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated DB, EIA, WB   0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Human Rabbit Un-conjugated DB, EIA, WB   0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-GCH1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1... WB Suggested Anti-GCH1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB GCH1 Antibody (N-term) (ABIN652021) western blot analysis in ZR-75-1 c... GCH1 Antibody (N-term) (ABIN652021) immunohistochemistry analysis in f... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IHC (p), IP, ELISA, WB Immunoperoxidase of monoclonal antibody to GCH1 on formalin-fixed para... GCH1 monoclonal antibody (M01), clone 4A12 Western Blot analysis of GC... 100 μg Log in to see 9 Days
$430.00
Details
Human Goat Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details

GCH1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,
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Mouse (Murine) , , , ,
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Rat (Rattus) , , , ,
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Top referenced anti-GTP Cyclohydrolase 1 Antibodies

  1. Human Monoclonal GCH1 Primary Antibody for IHC (p), IP - ABIN561018 : Widder, Chen, Li, Dikalov, Thöny, Hatakeyama, Harrison: Regulation of tetrahydrobiopterin biosynthesis by shear stress. in Circulation research 2007 (PubMed)
    Show all 11 references for ABIN561018

  2. Human Monoclonal GCH1 Primary Antibody for ELISA - ABIN395099 : Dabo, Grönbladh, Nyberg, Sundström-Poromaa, Akerud: Different SNP combinations in the GCH1 gene and use of labor analgesia. in Molecular pain 2010 (PubMed)
    Show all 5 references for ABIN395099

  3. Human Monoclonal GCH1 Primary Antibody for WB - ABIN396170 : Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010 (PubMed)
    Show all 5 references for ABIN396170

  4. Human Polyclonal GCH1 Primary Antibody for DB, EIA - ABIN493045 : Bergqvist, Werner, Apelqvist, Bugge, Wachter, Bengtsson: Brain biopterin metabolism in chronic experimental hepatic encephalopathy. in Metabolic brain disease 1995 (PubMed)
    Show all 3 references for ABIN493045

  5. Human Polyclonal GCH1 Primary Antibody for DB, EIA - ABIN493043 : Chen, Kallwitz, Leff, Cochran, Mufson, Kordower, Mandel: Age-related decreases in GTP-cyclohydrolase-I immunoreactive neurons in the monkey and human substantia nigra. in The Journal of comparative neurology 2000 (PubMed)
    Show all 3 references for ABIN493043

  6. Human Polyclonal GCH1 Primary Antibody for IP, IHC - ABIN1584545 : Meng, Liang, Li, Chen, Liu, Li: Changes of GTP cyclohydrolase I and neuronal apoptosis in rat spinal dorsal cord induced by sciatic nerve injury. in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2013 (PubMed)

More Antibodies against GTP Cyclohydrolase 1 Interaction Partners

Human GTP Cyclohydrolase 1 (GCH1) interaction partners

  1. Exonic deletion in the GCH1 gene only accounted for the etiology in a small percentage of patients with sporadic dopa-responsive dystonia in our Han Chinese cohort.

  2. identified a novel missense variant, c.5A > G, p.(Glu2Gly), within the GCH1 gene in affected family members displaying a range of phenotypes; variant is pathogenic in studied family and may underlie Parkinson's disease and Dopa-responsive dystonia

  3. No association was seen between the pain protective GCH-1 haplotype and the development of hypersensitivity following injury. An increase in baseline pain thresholds was seen between visits in protective haplotype carriers who sensitized to injury.

  4. Postherniotomy pain and related activity impairment was associated with functional variations in GCH1 (and COMT (show COMT Antibodies)).

  5. This is the first study to report changes in the expression of GTP Cyclohydrolase I of this gene in schizophrenia.

  6. Five polymorphisms forming two haplotype blocks within the GTP cyclohydrolase 1 gene are associated with endothelial dysfunction and oxidative stress.

  7. DYT5 is caused by heterozygous mutations of the GCH1 gene, located on 14q22.1-q22.2[review]

  8. This study supports to the conclusions that susceptibility to idiopathic dystonia is not greatly affected by common genetic variants of GCH1 polynorphisms.

  9. alterations in GCH1 activity affect attentional function, especially sustained attention and vigilance.

  10. Rare GCH1 variants are associated with an increased risk for Parkinson's disease.

Mouse (Murine) GTP Cyclohydrolase 1 (GCH1) interaction partners

  1. gene expression analysis after iNOS (show NOS2 Antibodies) induction identified 78 genes that were altered between wild-type and Gch1(fl/fl (show FLT3LG Antibodies))Tie2cre macrophages

  2. Data indicate that global deficiency in GTP cyclohydrolase I (Gch1) is embryonically lethal between E11.5 and E13.5.

  3. There is a cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.

  4. Inhibition of GCH1 prevented the Escherichia coli K1 induced expression of CD64 (show FCGR1A Antibodies) in macrophages in vitro and the development of bacteremia in a newborn mouse model of meningitis.

  5. The GTPCH I/Tetreahydrobiopterin pathway is critical to preserve endothelial progenitor cells quantity, function, and regenerative capacity during wound healing in type 1 diabetic mice.

  6. maintenance of endothelial GTPCH I expression and the resulting improvement in BH4 biosynthesis ameliorate diabetic nephropathy

  7. The involvement of the GCH1 gene in pain models using the hyperphenylalaninemia 1 (hph-1 (show EGLN2 Antibodies)) mouse, is reported.

  8. GTPCH1 non-covalently interacts with polyubiquitin via an ubiquitin-binding domain.

  9. The data suggest that GCH1 inhibition reduces tumor growth by (i) direct killing of tumor cells, (ii) by inhibiting angiogenesis, and (iii) by enhancing the antitumoral immune response

  10. Data indicate that myocardial nitric oxide synthase 1 (NOS1 (show NOS Antibodies)) activity was increased in GCH1 transgenic mice (mGCH1-Tg).

GTP Cyclohydrolase 1 (GCH1) Antigen Profile

Protein Summary

This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described\; however, not all variants give rise to a functional enzyme.

Gene names and symbols associated with GCH1

  • GTP cyclohydrolase 1 (GCH1) antibody
  • GTP cyclohydrolase 1 (gch1) antibody
  • GTP cyclohydrolase 1 (Celly_2302) antibody
  • GTP cyclohydrolase 1 (Celly_3166) antibody
  • GTP cyclohydrolase 1 (Weevi_1190) antibody
  • GTP cyclohydrolase 1 (Halhy_0838) antibody
  • GTP cyclohydrolase 1 (Sinme_1220) antibody
  • GTP cyclohydrolase 1 (Sphch_1077) antibody
  • GTP cyclohydrolase 1 (Gch1) antibody
  • DYT5 antibody
  • DYT5a antibody
  • DYT14 antibody
  • Gch antibody
  • gch1a antibody
  • GTP-CH antibody
  • GTP-CH-1 antibody
  • GTPCH antibody
  • GTPCH1 antibody
  • HPABH4B antibody
  • MGC89622 antibody
  • wu:fc16b10 antibody
  • zgc:195269 antibody

Protein level used designations for GCH1

GTP cyclohydrolase 1 (dopa-responsive dystonia) , GTP cyclohydrolase 1 , GTP cyclohydrolase I , GTP-CH-I , dystonia 14 , guanosine 5'-triphosphate cyclohydrolase I , GTP cyclohydrolase I (form A; N-terminus)

GENE ID SPECIES
286815 Bos taurus
609393 Canis lupus familiaris
695675 Macaca mulatta
743728 Pan troglodytes
448485 Xenopus (Silurana) tropicalis
10264325 Cellulophaga lytica DSM 7489
10265204 Cellulophaga lytica DSM 7489
10282422 Weeksella virosa DSM 16922
10584999 Haliscomenobacter hydrossis DSM 1100
10725797 Sinorhizobium meliloti AK83
10741394 Sphingobium chlorophenolicum L-1
100192219 Danio rerio
100286831 Oryctolagus cuniculus
100303455 Ovis aries
2643 Homo sapiens
14528 Mus musculus
29244 Rattus norvegicus
396146 Gallus gallus
100136794 Oncorhynchus mykiss
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