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GCH1 encodes a member of the GTP cyclohydrolase family. Additionally we are shipping GTP Cyclohydrolase 1 Proteins (12) and GTP Cyclohydrolase 1 Kits (5) and many more products for this protein.
Showing 10 out of 85 products:
Human Monoclonal GCH1 Primary Antibody for IHC (p), IP - ABIN561018
Widder, Chen, Li, Dikalov, Thöny, Hatakeyama, Harrison: Regulation of tetrahydrobiopterin biosynthesis by shear stress. in Circulation research 2007
Show all 11 references for ABIN561018
Human Monoclonal GCH1 Primary Antibody for ELISA - ABIN395099
Dabo, Grönbladh, Nyberg, Sundström-Poromaa, Akerud: Different SNP combinations in the GCH1 gene and use of labor analgesia. in Molecular pain 2010
Show all 5 references for ABIN395099
Human Monoclonal GCH1 Primary Antibody for WB - ABIN396170
Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010
Show all 5 references for ABIN396170
Human Polyclonal GCH1 Primary Antibody for DB, EIA - ABIN493045
Bergqvist, Werner, Apelqvist, Bugge, Wachter, Bengtsson: Brain biopterin metabolism in chronic experimental hepatic encephalopathy. in Metabolic brain disease 1995
Show all 3 references for ABIN493045
Human Polyclonal GCH1 Primary Antibody for DB, EIA - ABIN493043
Chen, Kallwitz, Leff, Cochran, Mufson, Kordower, Mandel: Age-related decreases in GTP-cyclohydrolase-I immunoreactive neurons in the monkey and human substantia nigra. in The Journal of comparative neurology 2000
Show all 3 references for ABIN493043
Human Polyclonal GCH1 Primary Antibody for IP, IHC - ABIN1584545
Meng, Liang, Li, Chen, Liu, Li: Changes of GTP cyclohydrolase I and neuronal apoptosis in rat spinal dorsal cord induced by sciatic nerve injury. in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2013
The risk of orofacial clefts is associated with variants of the GCH1 gene related to BH4 metabolism.
Exonic deletion in the GCH1 gene only accounted for the etiology in a small percentage of patients with sporadic dopa-responsive dystonia in our Han Chinese cohort.
identified a novel missense variant, c.5A > G, p.(Glu2Gly), within the GCH1 gene in affected family members displaying a range of phenotypes; variant is pathogenic in studied family and may underlie Parkinson's disease and Dopa-responsive dystonia
No association was seen between the pain protective GCH-1 haplotype and the development of hypersensitivity following injury. An increase in baseline pain thresholds was seen between visits in protective haplotype carriers who sensitized to injury.
Postherniotomy pain and related activity impairment was associated with functional variations in GCH1 (and COMT (show COMT Antibodies)).
This is the first study to report changes in the expression of GTP Cyclohydrolase I of this gene in schizophrenia.
Five polymorphisms forming two haplotype blocks within the GTP cyclohydrolase 1 gene are associated with endothelial dysfunction and oxidative stress.
DYT5 is caused by heterozygous mutations of the GCH1 gene, located on 14q22.1-q22.2[review]
This study supports to the conclusions that susceptibility to idiopathic dystonia is not greatly affected by common genetic variants of GCH1 polynorphisms.
alterations in GCH1 activity affect attentional function, especially sustained attention and vigilance.
gene expression analysis after iNOS (show NOS2 Antibodies) induction identified 78 genes that were altered between wild-type and Gch1(fl/fl (show FLT3LG Antibodies))Tie2cre macrophages
Data indicate that global deficiency in GTP cyclohydrolase I (Gch1) is embryonically lethal between E11.5 and E13.5.
There is a cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
Inhibition of GCH1 prevented the Escherichia coli K1 induced expression of CD64 (show FCGR1A Antibodies) in macrophages in vitro and the development of bacteremia in a newborn mouse model of meningitis.
The GTPCH I/Tetreahydrobiopterin pathway is critical to preserve endothelial progenitor cells quantity, function, and regenerative capacity during wound healing in type 1 diabetic mice.
maintenance of endothelial GTPCH I expression and the resulting improvement in BH4 biosynthesis ameliorate diabetic nephropathy
The involvement of the GCH1 gene in pain models using the hyperphenylalaninemia 1 (hph-1 (show EGLN2 Antibodies)) mouse, is reported.
GTPCH1 non-covalently interacts with polyubiquitin via an ubiquitin-binding domain.
The data suggest that GCH1 inhibition reduces tumor growth by (i) direct killing of tumor cells, (ii) by inhibiting angiogenesis, and (iii) by enhancing the antitumoral immune response
Data indicate that myocardial nitric oxide synthase 1 (NOS1 (show NOS Antibodies)) activity was increased in GCH1 transgenic mice (mGCH1-Tg).
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described\; however, not all variants give rise to a functional enzyme.
GTP cyclohydrolase 1 (dopa-responsive dystonia)
, GTP cyclohydrolase 1
, GTP cyclohydrolase I
, dystonia 14
, guanosine 5'-triphosphate cyclohydrolase I
, GTP cyclohydrolase I (form A; N-terminus)