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GIMAP4 encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. Additionally we are shipping GIMAP4 Antibodies (57) and GIMAP4 Proteins (5) and many more products for this protein.
GIMAP4 regulates secretion of cytokines in early differentiating human CD4 (show CD4 ELISA Kits)(+) T helper lymphocytes and in particular the secretion of interferon-gamma (show IFNG ELISA Kits) also affecting its downstream targets.
GIMAP1 (show GIMAP1 ELISA Kits) and GIMAP4 genes are up-regulated by IL-12 (show IL12A ELISA Kits) and other Th1 (show TH1L ELISA Kits) differentiation-inducing cytokines in cells induced to differentiate toward Th1 (show TH1L ELISA Kits) lineage and down-regulated by IL-4 (show IL4 ELISA Kits) in cells induced to Th2.
Gimap4 accelerates the execution of programmed cell death induced by intrinsic stimuli downstream of caspase-3 (show CASP3 ELISA Kits) activation and phosphatidylserine exposure. Apoptosis directly correlates with the phosphorylation status of Gimap4.
This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The encoded protein of this gene may be negatively regulated by T-cell acute lymphocytic leukemia 1 (TAL1). In humans, the IAN subfamily genes are located in a cluster at 7q36.1.
GTPase, IMAP family member 4
, GTPase IMAP family member 4
, human immune associated nucleotide 1
, immunity associated protein 4
, immunity-associated nucleotide 1 protein
, immunity-associated protein 4
, immune associated nucleotide 1
, immune-associated nucleotide 1