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GIMAP3 encodes a mitochondrial membrane protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins.
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quantitative changes in expression of Gimap3 and the paralogue Gimap5 affect mtDNA segregation in hematopoietic tissues. Gimap3 localizes to the endoplasmic reticulum and not mitochondria.
The defects in T-cell cellularity were more severe in mice lacking both Gimap3 and Gimap5.
Data shsow that Gimap3 is important for T cell development and survival, suggesting that leukocyte survival may be a key factor in the genetic regulation of mtDNA sequence variants and in modulating human mitochondrial diseases.
This gene encodes a mitochondrial membrane protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The expression of this gene is induced in BCR\\/ABL-expressing cells. The encoded protein lacks an N-terminal mitochondrial signal sequence. Experimental studies showed that mitochondrial localization relies on the C-terminal transmembrane domain. In humans, the IAN subfamily genes are located in a cluster at 7q36.1
GTPase IMAP family member 3
, immune associated nucleotide 4
, immunity-associated nucleotide 4 protein