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Galactose-1-phosphate uridyl transferase (GALT) catalyzes the second step of the Leloir pathway of galactose metabolism, namely the conversion of UDP-glucose + galactose-1-phosphate to glucose-1-phosphate + UDP-galactose. Additionally we are shipping Galactose-1-Phosphate Uridylyltransferase Proteins (24) and Galactose-1-Phosphate Uridylyltransferase Kits (9) and many more products for this protein.
Showing 10 out of 81 products:
Cow (Bovine) Polyclonal GALT Primary Antibody for WB - ABIN2783382
Karas-Kuzelicki, Pfeifer, Lukac-Bajalo: Synergistic effect of high lactase activity genotype and galactose-1-phosphate uridyl transferase (GALT) mutations on idiopathic presenile cataract formation. in Clinical biochemistry 2008
Our results thus demonstrated that GalT deficiency can effect down-regulation of the PI3K/Akt (show AKT1 Antibodies) growth signaling pathway in mouse fibroblasts through distinct mechanisms targeting both gene and protein expression levels.
Administration of a high-galactose (40% w/w) diet to lactating homozygous GalT gene-trapped females led to lethality in over 70% of the homozygous GalT gene-trapped pups before weaning.
Effects of GALT deficiency and dietary galactose on UDP-glucose pyrophosphorylase (show UGP2 Antibodies) and UDP-galactose (show B3GALT1 Antibodies) pyrophosphorylase activity and uridine diphosphate glucose expression in liver of mice with homozygous deletion of the critical regions of galt.
The finding is consistent with the function of UDP galactose (show B3GALT1 Antibodies) pyrophosphorylase as an alternate pathway of galactose metabolism.
Data show that PRL (show PRL Antibodies) signals through the short form of PRL (show PRL Antibodies) receptor RL, and causes, iin the absence of RL, a severe ovarian pathology by repressing the expression of FOXO3 (show FOXO3 Antibodies) and that of its target gene Galt.
we present the 1.9 A resolution crystal structure of human GALT (hGALT) ternary complex, revealing a homodimer arrangement that contains a covalent uridylylated intermediate and glucose-1-phosphate in the active site, as well as a structural zinc-binding site, per monomer
A novel noncoding homozygous GALT variant associated with asymptomatic galactosemia has been described in an infant of consanguineous heterozygous parents.
Mutation activates a cryptic donor splice site, inducing an aberrant splicing of the GALT pre-mRNA, which in turn leads to a frameshift with inclusion of a premature stop codon.
GALT activity in red blood cells of patients with galactosaemia
In Korean population, novel GALT mutations were identified in the galactosemia patients different from those of other populations.
suggests that GALT mutations are ethnic-specific and that galactosemia is a heterogeneous disorder at the molecular level
In this report, we present GALT gene mutations in 56 cases of galactosemia from Turkey identified using DNA microarray resequencing.
Data suggest that in classic galactosemia residual GALT activity (predicted from activity of recombinant GALT matching patient's mutation) correlates with reduced ovarian reserve (as indicted by biological marker, circulating anti-Mullerian hormone (show AMH Antibodies)).
The study determined the frequency of the two most common GALT mutations and their variants in Indian galactosemia patients.
The novel GALT gene mutations included 6 missense mutations viz. Y89H, Q103R, P166A, S181F, K285R, R333L; one nonsense mutation, S307X and 3 silent mutations--Q103Q, K210K and H319H.
Galactose-1-phosphate uridyl transferase (GALT) catalyzes the second step of the Leloir pathway of galactose metabolism, namely the conversion of UDP-glucose + galactose-1-phosphate to glucose-1-phosphate + UDP-galactose. The absence of this enzyme results in classic galactosemia in humans and can be fatal in the newborn period if lactose is not removed from the diet. The pathophysiology of galactosemia has not been clearly defined. Two transcript variants encoding different isoforms have been found for this gene.
, galactose-1-phosphate uridylyltransferase
, galactose-1P uridylyltransferase
, galactose-1-phosphate uridylyltransferase GALT
, galactose-1-phosphate uridylyltransferase, GalT
, GalT galactose-1-phosphate uridylyltransferase
, Galactose-1-phosphate uridylyltransferase
, UDP-glucose--hexose-1-phosphate uridylyltransferase
, gal-1-P uridylyltransferase
, galactose-1-phosphate uridyl transferase
, N-acetyllactosaminide alpha-1,3-galactosyltransferase
, UDP-galactose:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase
, alpha Gal
, glycoprotein alpha galactosyl transferase 1