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Galactosidase, alpha Proteins (GLA)

GLA encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. Additionally we are shipping GLA Antibodies (87) and GLA Kits (37) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GLA 2717 P06280
Rat GLA GLA 363494  
GLA 11605  
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Top GLA Proteins at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Mouse His tag 50 μg Log in to see 16 Days
$492.80
Details
HOST_Human Cells Human His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$756.80
Details
HOST_Wheat germ Human GST tag   10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$563.20
Details
Yeast Coffea His tag   1 mg Log in to see 56 to 66 Days
$2,992.00
Details
HOST_HEK293 Human His tag   50 μg Log in to see 5 Days
$423.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$747.45
Details

GLA Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
,
Mouse (Murine) ,
,

Top referenced GLA Proteins

  1. Human GLA Protein expressed in Human Cells - ABIN2005026 : Koide, Ishiura, Iwai, Inoue, Kaneda, Okada, Uchida: A case of Fabry's disease in a patient with no alpha-galactosidase A activity caused by a single amino acid substitution of Pro-40 by Ser. in FEBS letters 1990 (PubMed)
    Show all 5 references for ABIN2005026

  2. Mouse (Murine) GLA Protein expressed in Human Cells - ABIN2008459 : Yang, Lai, Whitehair, Hwu, Chiang, Lien: Two novel mutations in the alpha-galactosidase A gene in Chinese patients with Fabry disease. in Clinical genetics 2003 (PubMed)
    Show all 4 references for ABIN2008459

  3. Human GLA Protein expressed in Wheat germ - ABIN1355176 : Corchero, Mendoza, Lorenzo, Rodríguez-Sureda, Domínguez, Vázquez, Ferrer-Miralles, Villaverde: Integrated approach to produce a recombinant, His-tagged human ?-galactosidase A in mammalian cells. in Biotechnology progress 2011 (PubMed)

More Proteins for Galactosidase, alpha (GLA) Interaction Partners

Human Galactosidase, alpha (GLA) interaction partners

  1. We conclude that a mild GLA (show NAT8 Proteins) variant is typically characterized by high residual enzyme activity and normal biomarker levels. We found evidence that these variants can still be classified as a distinctive, but milder, sub-type of FD.

  2. Fabry disease, an X-linked disorder of glycosphingolipids that is caused by mutations of the GLA (show NAT8 Proteins) gene that codes for alpha-galactosidase A, leads to dysfunction of many cell types and includes a systemic vasculopathy.

  3. Study describes 5 novel mutations found in the GLA (show NAT8 Proteins) gene of patients with clinical diagnosis of Fabry disease.

  4. GLA (show NAT8 Proteins) gene variations correlate with globotriaosylceramide and globotriaosylsphingosine analog levels in urine and plasma

  5. results directly implicated the GLA (show NAT8 Proteins) mutation p.E66Q as the genetic etiology of the Chinese renal variant FD pedigree.

  6. This study indicated that the p.E66Q variant of GLA (show NAT8 Proteins) does not affect the progression of chronic kidney disease.

  7. Thus, inheritance of the CIH caused an mRNA deregulation altering the GLA (show NAT8 Proteins) expression pattern, producing a tissue glycolipid storage.

  8. data strongly suggest that the GLA (show NAT8 Proteins) p.(Arg118Cys) variant does not segregate with Fabry disease clinical phenotypes in a Mendelian fashion, but might be a modulator of the multifactorial risk of cerebrovascular disease

  9. In Fabry disease patients, the alpha-galactosidase A-10T allele appears to be causal for neurological manifestations.

  10. Some clinical cases of some members of a Sicilian family to express phenotypical variability of Anderson-Fabry disease in subjects with the same genetic mutation in alpha galactosidase A gene, are reported.

Mouse (Murine) Galactosidase, alpha (GLA) interaction partners

  1. In oocyte meiosis, GM130 (show GOLGA2 Proteins) localization and expression patterns are regulated by FMNL1 (show FMNL1 Proteins).

  2. The histological changes in Gla KO mice better resemble the type 2 later-onset phenotype observed in patients with residual alpha-galactosidase A activity.

  3. our findings imply that the alpha-GalA KO mouse is a good model in which to study the peripheral small fiber neuropathy exhibited by FD patients

  4. we demonstrate an age-dependent microvasculopathy of the mesenteric artery in a murine model of Fabry disease (galactosidase A-knockout mice) resulting from dysregulation of the vascular homeostatic enzyme endothelial nitric oxide synthase (eNOS (show NOS3 Proteins))

  5. GM130 (show GOLGA2 Proteins) regulates microtubule organization and might cooperate with the MAPK (show MAPK1 Proteins) pathway to play roles in spindle organization, migration and asymmetric division during mouse oocyte maturation

  6. It suggested that there could be a combination of GLA deficiency and FVL (show F5 Proteins) or other thrombosis-related gene defect in patients with genetic severe early-onset thrombosis.

  7. present Toll (show TLR4 Proteins)-like receptor-dependent negative regulation of alpha-Gal-A as a mechanistic link between pathogen recognition and self lipid antigen induction for natural killer T cells

  8. Developed a novel recombinant lentiviral vector that engineers expression of alpha-galactosidase. Analysis of tissues at 26 wks demonstrated similar alpha-gal A enzyme activities but enhanced Gb3 reduction in hearts and kidneys compared with control.

  9. alpha-galactosidase A deficiency could be an important genetic modifier for the enhanced thrombosis associated with FV Leiden associated thrombosis.

  10. The adeno (show ADORA2A Proteins)-associated virus (AAV) vector containing the alpha-gal A gene was injected into the right quadriceps muscles of Fabry knockout mice.

GLA Protein Profile

Protein Summary

This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties.

Gene names and symbols associated with Galactosidase, alpha Proteins (GLA)

  • galactosidase, alpha (GLA)
  • galactosidase, alpha (gla)
  • alpha-galactosidase (agaN)
  • aga (aga)
  • alpha-galactosidase (agaL)
  • alpha-galactosidase (SCO0541)
  • alpha-galactosidase (rafA)
  • alpha-galactosidase (melA)
  • Alpha-galactosidase (galA)
  • alpha-galactosidase A (ANI_1_2528074)
  • alpha-galactosidase A (ANI_1_1502124)
  • alpha-galactosidase A (AOR_1_390174)
  • alpha-galactosidase A (CpipJ_CPIJ002066)
  • alpha-galactosidase (aga)
  • alpha-galactosidase A (MCYG_00962)
  • alpha-galactosidase A (MCYG_00791)
  • alpha-galactosidase (gla)
  • alpha-galactosidase A (Tsp_02909)
  • alpha-galactosidase A (Tsp_02508)
  • galactosidase, alpha (Gla)
  • golgi autoantigen, golgin subfamily a, 2 (Golga2)
  • Ags protein
  • alpha-GAL protein
  • AO090005000217 protein
  • AW555139 protein
  • GALA protein
  • GM130 protein
  • MGC130872 protein
  • mKIAA4150 protein
  • SCF11.21 protein
  • SMU.877 protein
  • zgc:101584 protein

Protein level used designations for Galactosidase, alpha Proteins (GLA)

galactosidase, alpha , galactosidase alpha , Alpha-galactosidase A , alpha-D-galactosidase A , alpha-galactosidase A-like , alpha-galactosidase , Alpha-galactosidase , alpha-galactosidase A , agalsidase alfa , alpha-D-galactoside galactohydrolase 1 , alpha-gal A , melibiase , alpha-D-galactoside galactohydrolase , 130 kDa cis-Golgi matrix protein , Golgin subfamily A member 2 , SY11 protein , golgin-95

GENE ID SPECIES
280806 Bos taurus
465761 Pan troglodytes
703129 Macaca mulatta
734749 Xenopus laevis
100022779 Monodelphis domestica
100060370 Equus caballus
100145767 Xenopus (Silurana) tropicalis
100409841 Callithrix jacchus
100480888 Ailuropoda melanoleuca
100595113 Nomascus leucogenys
988766 Clostridium perfringens str. 13
1021683 Bifidobacterium longum NCC2705
1028243 Streptococcus mutans UA159
1095964 Streptomyces coelicolor A3(2)
1174420 Yersinia pestis CO92
1255824 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
2956399 Yersinia pseudotuberculosis IP 32953
3977399 Lactobacillus salivarius UCC118
4983447 Aspergillus niger CBS 513.88
4987403 Aspergillus niger CBS 513.88
5989256 Aspergillus oryzae RIB40
6032795 Culex quinquefasciatus
7264928 Bifidobacterium animalis subsp. lactis AD011
9223595 Arthroderma otae CBS 113480
9226616 Arthroderma otae CBS 113480
9450395 Brachyspira pilosicoli 95/1000
10899858 Trichinella spiralis
10903123 Trichinella spiralis
2717 Homo sapiens
363494 Rattus norvegicus
450083 Danio rerio
422188 Gallus gallus
532742 Bos taurus
11605 Mus musculus
100344610 Oryctolagus cuniculus
100718405 Cavia porcellus
407057 Sus scrofa
480988 Canis lupus familiaris
99412 Mus musculus
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