anti-Galactosylceramidase (GALC) Antibodies

GALC encodes a lysosomal protein which hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Additionally we are shipping Galactosylceramidase Kits (10) and Galactosylceramidase Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GALC 2581 P54803
GALC 14420 P54818
GALC 314360  
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Top anti-Galactosylceramidase Antibodies at

Showing 10 out of 65 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-GALC Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
Human Rabbit Un-conjugated IHC, IHC (p), WB Immunohistochemistry-Paraffin: Galactosylceramidase/GALC Antibody [NBP2-16578] - Paraffin-embedded rat liver. Galactosylceramidase antibody diluted at 1:400. Western Blot: GALC Antibody [NBP2-16578] - Sample (30 ug of whole cell lysate) A: H1299 7. 5% SDS PAGE gel, diluted at 1:1000. 0.1 mL Log in to see 8 to 11 Days
Human Rabbit Un-conjugated WB WB Image Sample (30 ug of whole cell lysate) A: H1299 7.5% SDS PAGE Galactosylceramidase antibody antibody diluted at 1:1000 100 μL Log in to see 1 to 2 Days
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti-Galc Polyclonal Antibody, Unconjugated (ABIN708101) at 1:200 followed by conjugation to the secondary antibody, (SP-0023), and DAB staining L1 rat brain, L2 rat liver lysates probed (ABIN708101) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted and observed band size: 71kDa. 100 μL Log in to see 3 to 7 Days
Dog Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated WB GALC antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 2 to 3 Days
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
Human Rabbit Alexa Fluor 647 IF (p)   100 μL Log in to see 14 to 21 Days

GALC Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , , ,
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Mouse (Murine) , , ,

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Rat (Rattus) , , ,

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More Antibodies against Galactosylceramidase Interaction Partners

Human Galactosylceramidase (GALC) interaction partners

  1. Enzyme activities (acid alpha-glucosidase (GAA), galactocerebrosidase (GALC), glucocerebrosidase (GBA (show GBA Antibodies)), alpha-galactosidase A (GLA (show GLA Antibodies)), alpha-iduronidase (IDUA (show IDUA Antibodies)) and sphingomyeline phosphodiesterase-1 (SMPD-1 (show SMPD1 Antibodies))) were measured on ~43,000 de-identified dried blood spot (DBS (show MCF2L Antibodies)) punches, and screen positive samples were submitted for DNA sequencing to obtain genotype confirmation of disease risk

  2. This review illustrated The Krabbe's disease is caused by mutation in the enzyme Beta-galactocerebrosidase.

  3. This is the largest expression study of GALC variants/mutations found in Newborn screening and confirmed KD cases.

  4. We demonstrated that a heterozygous GALC deletion does not play a significant role in the pathogenesis of normal tension glaucoma in a representative clinic-based population of South Koreans, unlike whites.

  5. Mutations in GALC cause late-onset Krabbe disease with predominant cerebellar ataxia

  6. promoter hypermethylation contributed to down-regulation of GALC Gene, implicating epigenetic inactivation of GALC may play a role in tumorigenesis of cancer.

  7. Case Report: compound GALC heterozygosity in a boy with infantile Krabbe disease with severe clinical course.

  8. GALC was downregulated by promoter hypermethylation and contributed to the pathogenesis of EBV-associated nasopharyngeal carcinoma

  9. Genetic variants near IREB2 (show IREB2 Antibodies) and GALC likely contribute to genetic susceptibility to PAE associated with COPD (show ARCN1 Antibodies).

  10. Structural snapshots illustrate the catalytic cycle of beta-galactocerebrosidase, the defective enzyme in Krabbe disease.

Mouse (Murine) Galactosylceramidase (GALC) interaction partners

  1. Data show that transgenic galactocerebrosidase (GALC) activity was mainly localized at the Purkinje cells layer in the cerebellum of the AAV-treated twitcher mice.

  2. The results of this study indicated that the greater neurochemical pathology observed in the optic nerve than in the sciatic nerve of beta-gal (show GLB1 Antibodies) -/- mice is likely due to the greater glycolipid storage in optic nerve.

  3. This study demonistrated that galactosylceramidase Deficiency also casue neuromuscular dysfunction.

  4. results show that GALCtwi-5J, a spontaneous mutation in murine GALC precisely matches the E130K missense mutation in patients with infantile Krabbe disease

  5. Insights into the mechanisms underlying galactosylceramidase regulation of early post-natal neurogenic niches improve our understanding of the multi-component pathology of globoid cell leukodystrophy .

  6. The crystal structures of GALC and the GALC-product complex, revealing a novel domain architecture with a previously uncharacterized lectin domain not observed in other hydrolases, are presented.

  7. Data show that GALC and, possibly, other enzymes for the maintenance of niche functionality and health tightly control the concentration of these sphingolipids within HSPCs.

  8. GALC is not restricted to myelinating cells but also to several neuronal cell types in the nervous system, such as hippocampal pyramidal neurons and cerebellar neurons.

  9. Direct administration of these viral particles into the brains of neonatal mice with globoid cell leukodystrophy resulted in sustained expression of GALC activity, improved myelination

  10. mutant oligodendrocytes can internalize exogenous galactocerebrosidase and maintain stable myelin, demonstrating that exogenous enzyme replacement will be a key strategy in the therapy of globoid cell leukodystrophy

Galactosylceramidase (GALC) Antigen Profile

Protein Summary

This gene encodes a lysosomal protein which hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Mutations in this gene have been associated with Krabbe disease, also known as globoid cell leukodystrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with GALC

  • galactosylceramidase (GALC) antibody
  • galactosylceramidase a (galca) antibody
  • galactosylceramidase (galc) antibody
  • Galactosylceramidase (Caci_7107) antibody
  • Galactosylceramidase (Bacsa_1415) antibody
  • Galactosylceramidase (Spico_0384) antibody
  • Galactosylceramidase (LOC100304802) antibody
  • galactosylceramidase L homeolog (galc.L) antibody
  • galactosylceramidase (Galc) antibody
  • 2310068B06Rik antibody
  • A930008M05Rik antibody
  • AW212969 antibody
  • AW413532 antibody
  • Gacy antibody
  • galc antibody
  • GALCERase antibody
  • galcl antibody
  • si:ch211-199l3.4 antibody
  • twi antibody
  • twitcher antibody
  • zgc:92561 antibody

Protein level used designations for GALC

galactocerebrosidase , GALCERase , galactosylceramidase like , Galactosylceramidase , Galactocerebrosidase , galactocerebroside beta-galactosidase , galactosylceramide beta-galactosidase , galactosylceraminidase , galactosylceramidase (Krabbe disease)

100034130 Equus caballus
449649 Danio rerio
779723 Xenopus (Silurana) tropicalis
8338474 Catenulispora acidiphila DSM 44928
10259317 Bacteroides salanitronis DSM 18170
10494670 Sphaerochaeta coccoides DSM 17374
100304802 Ictalurus punctatus
100195231 Salmo salar
446948 Xenopus laevis
2581 Homo sapiens
403916 Canis lupus familiaris
533428 Bos taurus
14420 Mus musculus
314360 Rattus norvegicus
693322 Macaca mulatta
423394 Gallus gallus
100156917 Sus scrofa
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