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Galanin is small neuropeptide that functions as a cellular messenger within the central and peripheral nervous systems, modulating diverse physiologic functions (Mechenthaler, 2008 [PubMed 18500643]).[supplied by OMIM, Jan 2009].. Additionally we are shipping GAL Antibodies (38) and GAL Kits (18) and many more products for this protein.
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Galanin, acting via the GAL1 (show LGALS1 Proteins) receptor and Gi -coupled signalling in L and K cells, is a potent inhibitor of GLP-1 (show GCG Proteins) and GIP (show GIP Proteins) secretion
Galanin released by cancer induces neuritogenesis, facilitating perineural invasion.
Study shows that LIF (show LIF Proteins)-treated postmitotic oligodendrocytes secrete a number of neuropeptides, in particular galanin, at the mRNA and peptide level, and galanin itself was shown to be a survival factor for oligodendrocytes
Results suggest that GAL is a regulator of myelination, as demonstrated by MBP (show MBP Proteins) synthesis, and may be one of the myelination promoters
Oleuropein protects mice from gh-fat diet induced adiposity by upregulation of genes involved in WNT10b (show WNT10B Proteins)-mediated signaling and downregulation of genes involved in galanin-mediated signaling cascades.
medial preoptic area galanin neurons emerge as an essential regulatory node of male and female parenting behaviour and other social responses
Analysis of the gene proximal region using EMSA and ChIP assays showed that CREB (show CREB1 Proteins) protein interacts with the galanin promoter both in vitro and in vivo. Additional EMSA analysis revealed that an SP1 (show SP1 Proteins) consensus site mediated protein-DNA complex formation.
The expression of mRNA galanin is increased following chronic restraint stress.
These results suggest that sertraline-related galanin induction in ventral dentate gyrus may play an important role in therapeutic mechanisms for depression.
extended perifornical area galanin-LepRb (show LEPR Proteins) neurons galanin acts inhibitory rather than orexigenic
Data show that PKA and PKC pathways are involved in the differential regulation of production of the neuropeptides (Met)enkephalin, galanin, somatostatin (show SST Proteins), NPY (show NPY Proteins), and VIP (show Vip Proteins).
results indicated that obese individuals have higher plasma GAL and GALP (show GALP Proteins) concentrations and both peptide concentrations were positively correlative to triglyceride concentrations in obese human
GAL and its receptors, GALR1 and GALR2 (show GALR2 Proteins), play a role in head and neck squamous cell carcinoma tumorigenesis
Elevated galanin may predict the risk of type 2 diabetes mellitus for development of Alzheimer's disease.
This study demonstrated that Galanin upregulation within the basal forebrain cholinergic system in LBD
Mutations in the human GAL gene cause temporal lobe epilepsy.
Galangin-induced down-regulation of BACE1 (show BACE Proteins) by epigenetic mechanisms
This is the first report of the various galanin receptors in the human eye.
Galanin can be regarded as an immunomodulatory peptide as it can sensitize polymorphonuclear neutrophils towards pro-inflammatory cytokines in humans and mice.
found no association of the galanin enhancer genotype with any of the other pathophysiological parameters measured
Localization of galanin, in the nerve fibers of porcine cystic ovaries
Galanin is small neuropeptide that functions as a cellular messenger within the central and peripheral nervous systems, modulating diverse physiologic functions (Mechenthaler, 2008
galanin prepropeptide, gene 2
, galanin peptides
, galanin prepropeptide
, galanin-message-associated peptide
, galanin-related peptide