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Ganglioside-Induced Differentiation-Associated Protein 1 Proteins (GDAP1)

GDAP1 encodes a member of the ganglioside-induced differentiation-associated protein family, which may play a role in a signal transduction pathway during neuronal development. Additionally we are shipping GDAP1 Antibodies (29) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GDAP1 54332 Q8TB36
GDAP1 14545 O88741
Rat GDAP1 GDAP1 312890  
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Top GDAP1 Proteins at antibodies-online.com

Showing 3 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

GDAP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Ganglioside-Induced Differentiation-Associated Protein 1 (GDAP1) Interaction Partners

Human Ganglioside-Induced Differentiation-Associated Protein 1 (GDAP1) interaction partners

  1. This study suggest GDAP1 as the first gene that should be analysed in Italian patients affected by CMT2.

  2. study reports on 2 Charcot-Marie-Tooth (CMT) families in which a newly identified Glu222Lys mutation within the GDAP1 gene segregates both in autosomal dominant and recessive traits

  3. The novelty of our data is the relatively high frequency of SH3TC2 and GDAP1 mutations in demyelinating and axonal forms, respectively, of Charcot-Marie-Tooth disease

  4. Results show that JPH1 (show JPH1 Proteins) and GDAP1 share a common pathway and depend on each other; therefore, JPH1 (show JPH1 Proteins) can contribute to the phenotypical consequences of GDAP1 mutations.

  5. GDAP1-associated polyneuropathy caused predominantly a mild and slowly progressive phenotype.

  6. This studies suggest that the pathophysiology of GDAP1-related CMT neuropathies may be associated with abnormal distribution and movement of mitochondria throughout cytoskeleton towards the ER and subplasmalemmal microdomains.

  7. GDAP1 regulates mitochondrial and peroxisomal fission by a similar mechanism.

  8. A novel heterozygous missense mutation (Arg120Gly) in the GDAP1 gene co-segregates with the disease within the pedigree of an Italian Charcot-Marie-Tooth disease type 2 (CMT2) family.

  9. This study suggested that the mutation of GDAP1 cased onion bulb-like formations of schwann cell in peripheral neuropathies.

  10. A French family with Charcot-Marie-Tooth disease is related to simultaneous heterozygous MFN2 (show MFN2 Proteins) and GDAP1 mutations.

Mouse (Murine) Ganglioside-Induced Differentiation-Associated Protein 1 (GDAP1) interaction partners

  1. absence of GDAP1 induces a peripheral neuropathy with loss of motor neurons, mitochondrial defects and abnormal calcium homeostasis.

  2. Members of the GDAP1 family are responsive and protective against stress associated with increased levels of oxidized glutathione.

  3. Cell expression of Gdap1 in the nervous system and pathogenesis of Charcot-Marie-Tooth type 4A disease are reported.

GDAP1 Protein Profile

Protein Summary

This gene encodes a member of the ganglioside-induced differentiation-associated protein family, which may play a role in a signal transduction pathway during neuronal development. Mutations in this gene have been associated with various forms of Charcot-Marie-Tooth Disease and neuropathy. Two transcript variants encoding different isoforms and a noncoding variant have been identified for this gene.

Gene names and symbols associated with GDAP1

  • ganglioside induced differentiation associated protein 1 (GDAP1)
  • ganglioside-induced differentiation-associated protein 1 (GDAP1)
  • ganglioside-induced differentiation-associated-protein 1 (Gdap1)
  • CMT4 protein
  • CMT4A protein
  • CMTRIA protein

Protein level used designations for GDAP1

ganglioside-induced differentiation-associated protein 1 , Charcot-Marie-Tooth neuropathy 4A , ganglioside differentiation associated protein 1

GENE ID SPECIES
100172660 Pongo abelii
100050935 Equus caballus
54332 Homo sapiens
420191 Gallus gallus
487002 Canis lupus familiaris
100157012 Sus scrofa
613472 Bos taurus
14545 Mus musculus
312890 Rattus norvegicus
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