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Gap Junction Protein, alpha 3, 46kDa Proteins (GJA3)

The protein encoded by GJA3 is a connexin and is a component of lens fiber gap junctions. Additionally we are shipping Gap Junction Protein, alpha 3, 46kDa Antibodies (55) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GJA3 14611 Q64448
Rat GJA3 GJA3 79217 P29414
GJA3 2700 Q9Y6H8
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Top Gap Junction Protein, alpha 3, 46kDa Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
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Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details

GJA3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human ,
,

More Proteins for Gap Junction Protein, alpha 3, 46kDa (GJA3) Interaction Partners

Xenopus laevis Gap Junction Protein, alpha 3, 46kDa (GJA3) interaction partners

  1. Data suggest that, in gap junctions of Xenopus oocytes, Cx50 (connexin 50 (show GJA8 Proteins)) but not Cx46 (connexin 46) is regulated by phosphatidylinositol 3-kinase (PIK3C2A (show PIK3C2A Proteins)) signaling pathway.

Zebrafish Gap Junction Protein, alpha 3, 46kDa (GJA3) interaction partners

  1. Cx48.5, Cx44.1, Cx43 (show GJA1 Proteins) have roles in lens development

  2. Connexin 48.5 has a role in normal cardiovascular function and lens development in zebrafish embryos

Mouse (Murine) Gap Junction Protein, alpha 3, 46kDa (GJA3) interaction partners

  1. that expression and phosphorylation of connexin 46 and connexin 45 (show GJC1 Proteins) are complementary in seminiferous tubules

  2. The localization and sizes of Cx50 (show GJA8 Proteins) gap junction plaques in DKO fibers were unaffected, suggesting that Cx46 and Cx50 (show GJA8 Proteins) form homomeric channels

  3. Data indicate that connexin 46 (cx46) is essential for the maintenance of adequate levels of glutathione (GSH) in the lens nucleus.

  4. Cx46 was severely reduced in both heterozygous and homozygous Cx46fs380 lenses at 1 month of age, whereas immunoreactive connexin50 (Cx50 (show GJA8 Proteins)) was moderately decreased.

  5. Results suggest that Cx46 hemichannels may contribute to the sodium leak conductance in lens fiber cells.

  6. Data show that Ca(V) 1.2 and 1.3 channels are expressed in lens, regulating phosphorylation of aquaporin-0 and myosin light chain and expression of connexins 50 and 46.

  7. These results provide further evidence that Cx43 (show GJA1 Proteins) and Cx46 form both heterotypic and heteromeric channels when co-expressed.

  8. nonspecific restoration of communication by Cx46 maintained differentiation of lens cells

  9. Results indicates connexin 46 expressed alone are recruited into different lipid environments and interaction of connexins and MP26 contributes to the overall organization of the fiber cells.

Human Gap Junction Protein, alpha 3, 46kDa (GJA3) interaction partners

  1. Taken together, in Jar (show MYO6 Proteins) cells, placental connexins 43 and 46 are regulated during periods of low oxygen in opposite manners

  2. A novel missense GJA3 mutation that correlated with congenital cataract phenotype in a five-generation Chinese family.

  3. This study identified three mutations in three Chinese families with hereditary cataracts. Of the three mutations, two were novel (c.125 A > C in GJA3 and c.268 C > T in GJA3), one was previously reported (c.218 C > T in GJA8 (show GJA8 Proteins)).

  4. Glioblastoma cancer stem cells (CSCs) express Cx46, while Cx43 is predominantly expressed in non-CSCs. During differentiation, Cx46 is reduced, while Cx43 is increased, and targeting Cx46 compromises CSC maintenance

  5. A novel missense mutation, c.428G>A (p.G143E), in the GJA3 gene, localized to the cytoplasmic loop, was suggested to be the genetic cause of congenital nuclear cataract, which further expands the gene mutation spectrum.

  6. A novel GJA3 mutation (p.N55D) has been found in a Chinese family with congenital cataracts.

  7. The crystallin beta cluster on chromosome 22, GJA3, and BFSP1 (show BFSP1 Proteins) play a major role in maintaining lens transparency.

  8. a GJA3 mutation in a Chinese family with congenital nuclear cataract

  9. these results suggest that mutation of this highly conserved residue on the cytoplasmic loop domain of Cx46 enhances its interaction with the C-terminus, resulting in a reduction of gap junction channel function

  10. A 1361 insertion of a cytosine mutation in the C-terminus of GJA3 is found to be associated with autosomal dominant congenital coralliform cataract.

Cow (Bovine) Gap Junction Protein, alpha 3, 46kDa (GJA3) interaction partners

  1. AQP-0 and connexins can be segregated in the membrane by protein-lipid interactions as modified by AQP-0 homo-oligomerization

Gap Junction Protein, alpha 3, 46kDa (GJA3) Protein Profile

Protein Summary

The protein encoded by this gene is a connexin and is a component of lens fiber gap junctions. Defects in this gene are a cause of zonular pulverulent cataract type 3 (CZP3).

Gene names and symbols associated with GJA3

  • gap junction protein, alpha 3, 46kDa (gja3)
  • connexin 46 (LOC100225310)
  • gap junction protein, alpha 3, 46kDa (GJA3)
  • gap junction protein, alpha 3 (gja3)
  • gap junction protein, alpha 3 (Gja3)
  • Cnx46 protein
  • CTRCT14 protein
  • Cx43 protein
  • Cx44 protein
  • CX46 protein
  • cx48.5 protein
  • CZP3 protein
  • Gja-3 protein
  • MGC53082 protein

Protein level used designations for GJA3

gap junction protein, alpha 3, 46kDa , connexin 46 , alpha3 connexin , gap junction protein, alpha 3, 46kDa (connexin 46) , gap junction alpha-3 protein-like , connexin 48.5 , dco , dococ , gap junction alpha-3 protein , gap junction membrane channel protein alpha 3 , unm s215 , unm s226 , alpha 3 connexin , connexin-46 , cx46 , connexin-44 , cx44 , connexin-56 , cx56

GENE ID SPECIES
379171 Xenopus laevis
100135710 Xenopus (Silurana) tropicalis
100225310 Taeniopygia guttata
467218 Pan troglodytes
486052 Canis lupus familiaris
704432 Macaca mulatta
100441955 Pongo abelii
387533 Danio rerio
14611 Mus musculus
79217 Rattus norvegicus
2700 Homo sapiens
100140301 Bos taurus
428084 Gallus gallus
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