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Gap Junction Protein, alpha 5, 40kDa Proteins (GJA5)

GJA5 is a member of the connexin gene family. Additionally we are shipping GJA5 Antibodies (78) and GJA5 Kits (36) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GJA5 50563 P28234
GJA5 14613 Q01231
GJA5 2702 P36382
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Top GJA5 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$704.00
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 19 Days
$889.07
Details

GJA5 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Mouse (Murine) ,
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Human ,
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More Proteins for Gap Junction Protein, alpha 5, 40kDa (GJA5) Interaction Partners

Mouse (Murine) Gap Junction Protein, alpha 5, 40kDa (GJA5) interaction partners

  1. High-fat diet increases vulnerability to atrial arrhythmia by down-regulation of Cx40 via miR (show MLXIP Proteins)-27b.

  2. Report interaction between ALK1 (show ACVRL1 Proteins) signaling and connexin40 in the development of arteriovenous malformations.

  3. Cx40 is a requirement for the pressure control of renin (show REN Proteins) secretion irrespective of the localization of renin (show REN Proteins) secreting cells.

  4. Cx37 (show GJA4 Proteins) is more markedly involved in basal NO release, release of cyclooxygenase products and the regulation of the sensitivity for Acetylcholine as compared to Cx40.

  5. This study showed the progressive changes of Cx 40 at protein and mRNA levels in the mouse hippocampus during and after pilocarpine-induced status epilepticus.

  6. Cx40 and Cx37 (show GJA4 Proteins) play an in vivo role in the regulation of eNOS (show NOS3 Proteins).

  7. Endothelial connexin 40, but not connexin 37 (show GJA4 Proteins), is implicated in resistance of the heart to ischaemia/reperfusion injury by activation of the CD73 pathway

  8. Data indicate the role of renin (show REN Proteins) in hypertension linked to loss of connexin 40 (Cx40).

  9. connecxin 40 contributes to the propagation Ca2 (show CA2 Proteins)+ signaling triggered by Acetylcholine in endothelial cells expressing the M3 muscarinic receptors.

  10. genetic polymorphisms in endothelial Cx40 can contribute to the pathogenesis of arterial disease.

Human Gap Junction Protein, alpha 5, 40kDa (GJA5) interaction partners

  1. This is a review summarizing atrial fibrillation-linked somatic and germline mutations in the gene encoding Cx40. Multiple impairments were observed in these mutants, including impaired gap junction function by abnormal localization or function, as well as increased hemichannel function.

  2. Human atrial myocytes express Cx40 and Cx43 (show GJA1 Proteins). However, in vitro expression study indicates that human Cx40 is not able to dock with Cx43 (show GJA1 Proteins) to form heterotypic gap junction channels. This study designed two Cx40 variants, D55N or P193Q. Both of them were successful in forming functional heterotypic gap junction channels with Cx43 (show GJA1 Proteins).

  3. Two polymorphisms in the Cx40 promoter are associated with hypertension and left ventricular hypertrophy preferentially in men.

  4. Report interaction between ALK1 (show ACVRL1 Proteins) signaling and connexin40 in the development of arteriovenous malformations.

  5. Reduced Cx40 levels and heterogeneity of its distribution (relative to Cx43 (show GJA1 Proteins)) are common in atrial fibrillation.

  6. Two atrial fibrillation-linked germline Cx40 mutants, V85I and L221I, were investigated.

  7. These findings provide evidence that the connexin 40 Q49X mutant is capable of impairing gap-junction distribution and function of key atrial connexins, which might play a role in the predisposition to and onset of atrial fibrillation.

  8. 17-beta-estradiol modulates connexins and integrins as well as ER-beta (show ESR2 Proteins) expression induced by high frequency electromagnetic fields.

  9. 4 novel heterozygous GJA5 mutations, p.K107R, p.L223M, p.Q236H and p.I257L, were identified in 4 of 310 unrelated AF patients.

  10. the germline familial mutations in Cx40 impair the gap junctions through different mechanisms, which may predispose the mutant carriers to AF.

GJA5 Protein Profile

Protein Summary

This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene may be associated with atrial fibrillation. Alternatively spliced transcript variants encoding the same isoform have been described.

Gene names and symbols associated with GJA5

  • gap junction protein, alpha 5 (Gja5)
  • gap junction protein, alpha 5, 40kDa (GJA5)
  • 5730555N10Rik protein
  • ATFB11 protein
  • Cnx40 protein
  • CX40 protein
  • Gja-5 protein

Protein level used designations for GJA5

connexin 40 , connexin-40 , gap junction alpha-5 protein , gap junction membrane channel protein alpha 5 , gap junction protein alpha 5 , gap junction protein, alpha 5, 40kDa (connexin 40) , cx40 , connexin-42 , cx42

GENE ID SPECIES
50563 Rattus norvegicus
14613 Mus musculus
2702 Homo sapiens
483155 Canis lupus familiaris
539491 Bos taurus
396502 Gallus gallus
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