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GJA5 is a member of the connexin gene family. Additionally we are shipping GJA5 Antibodies (80) and GJA5 Kits (29) and many more products for this protein.
Showing 5 out of 6 products:
High-fat diet increases vulnerability to atrial arrhythmia by down-regulation of Cx40 via miR (show MLXIP Proteins)-27b.
Report interaction between ALK1 (show ACVRL1 Proteins) signaling and connexin40 in the development of arteriovenous malformations.
Cx40 is a requirement for the pressure control of renin (show REN Proteins) secretion irrespective of the localization of renin (show REN Proteins) secreting cells.
Cx37 (show GJA4 Proteins) is more markedly involved in basal NO release, release of cyclooxygenase products and the regulation of the sensitivity for Acetylcholine as compared to Cx40.
This study showed the progressive changes of Cx 40 at protein and mRNA levels in the mouse hippocampus during and after pilocarpine-induced status epilepticus.
Cx40 and Cx37 (show GJA4 Proteins) play an in vivo role in the regulation of eNOS (show NOS3 Proteins).
Endothelial connexin 40, but not connexin 37 (show GJA4 Proteins), is implicated in resistance of the heart to ischaemia/reperfusion injury by activation of the CD73 pathway
Data indicate the role of renin (show REN Proteins) in hypertension linked to loss of connexin 40 (Cx40).
connecxin 40 contributes to the propagation Ca2 (show CA2 Proteins)+ signaling triggered by Acetylcholine in endothelial cells expressing the M3 muscarinic receptors.
genetic polymorphisms in endothelial Cx40 can contribute to the pathogenesis of arterial disease.
Cx40 genetic polymorphisms increase atrial fibrillation risk in Uyghur and Han residents of Xinjiang.
Cx 40 (rs35594137) was associated with atrial fibrillation; in the Uygur population, Cx 40 (rs35594137) should be considered as an independent risk factor for patients with atrial fibrillation, who might have racial differences in rs35594137 variant frequencies
This is a review summarizing atrial fibrillation-linked somatic and germline mutations in the gene encoding Cx40. Multiple impairments were observed in these mutants, including impaired gap junction function by abnormal localization or function, as well as increased hemichannel function.
Human atrial myocytes express Cx40 and Cx43 (show GJA1 Proteins). However, in vitro expression study indicates that human Cx40 is not able to dock with Cx43 (show GJA1 Proteins) to form heterotypic gap junction channels. This study designed two Cx40 variants, D55N or P193Q. Both of them were successful in forming functional heterotypic gap junction channels with Cx43 (show GJA1 Proteins).
Two polymorphisms in the Cx40 promoter are associated with hypertension and left ventricular hypertrophy preferentially in men.
Reduced Cx40 levels and heterogeneity of its distribution (relative to Cx43 (show GJA1 Proteins)) are common in atrial fibrillation.
Two atrial fibrillation-linked germline Cx40 mutants, V85I and L221I, were investigated.
These findings provide evidence that the connexin 40 Q49X mutant is capable of impairing gap-junction distribution and function of key atrial connexins, which might play a role in the predisposition to and onset of atrial fibrillation.
17-beta-estradiol modulates connexins and integrins as well as ER-beta (show ESR2 Proteins) expression induced by high frequency electromagnetic fields.
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene may be associated with atrial fibrillation. Alternatively spliced transcript variants encoding the same isoform have been described.
, gap junction alpha-5 protein
, gap junction membrane channel protein alpha 5
, gap junction protein alpha 5
, gap junction protein, alpha 5, 40kDa (connexin 40)