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anti-Gap Junction Protein, alpha 8, 50kDa (GJA8) Antibodies

GJA8 encodes a transmembrane connexin protein that is necessary for lens growth and maturation of lens fiber cells. Additionally we are shipping Gap Junction Protein, alpha 8, 50kDa Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GJA8 14616 P28236
GJA8 29601  
GJA8 2703 P48165
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Top anti-Gap Junction Protein, alpha 8, 50kDa Antibodies at antibodies-online.com

Showing 10 out of 54 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-GJA8 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Mouse Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-GJA8 Antibody (N-term) (ABIN1882072) in HepG2 cell line lysates (35 µg/lane). GJA8(arrow) was detected using the purified Pab. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-GJA8 Antibody (C-term) (ABIN388381) in mouse kidney tissue lysates (35 µg/lane). GJA8 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Mouse Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Goat Un-conjugated ELISA   0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated IHC, WB 400 μL Log in to see 6 Days
$457.14
Details
Sheep Mouse Un-conjugated IF, IP, ELISA, WB   100 μg Log in to see 8 to 10 Days
$771.83
Details

GJA8 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,
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Rat (Rattus) ,
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Human ,
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Top referenced anti-Gap Junction Protein, alpha 8, 50kDa Antibodies

  1. Human Polyclonal GJA8 Primary Antibody for WB - ABIN1882072 : Shiels, Mackay, Ionides, Berry, Moore, Bhattacharya: A missense mutation in the human connexin50 gene (GJA8) underlies autosomal dominant "zonular pulverulent" cataract, on chromosome 1q. in American journal of human genetics 1998 (PubMed)
    Show all 4 references for ABIN1882072

  2. Human Polyclonal GJA8 Primary Antibody for WB - ABIN2774860 : Arora, Minogue, Liu, Addison, Russel-Eggitt, Webster, Hunt, Ebihara, Beyer, Berthoud, Moore: A novel connexin50 mutation associated with congenital nuclear pulverulent cataracts. in Journal of medical genetics 2008 (PubMed)

More Antibodies against Gap Junction Protein, alpha 8, 50kDa Interaction Partners

Mouse (Murine) Gap Junction Protein, alpha 8, 50kDa (GJA8) interaction partners

  1. Study showed that mouse horizontal cells establish a coupled dendritic network by Cx57 and two coupled axon terminal networks, one made of Cx50 and the other made of Cx57 channels

  2. data show that expression and phosphorylation of Cx46 (show GJA3 Antibodies) and Cx50 are complementary in seminiferous tubules

  3. demonstrate, at the whole gap junction channel level, a crucial role of the surface charge properties in the first transmembrane/first extracellular border domain in determining the efficiency of ion permeation and the Vj gating of Cx50

  4. Data show that Ca(V) 1.2 and 1.3 channels are expressed in lens, regulating phosphorylation of aquaporin-0 and myosin light chain and expression of connexins 50 and 46.

  5. The Gja8(R205G) mutation differentially impairs the functions of Cx50 and Cx46 (show GJA3 Antibodies) to cause cataracts, small lenses and microphthalmia.

  6. D3 residue plays an essential role in unitary conductance of Cx50 gap junction channels

  7. Norma (show INADL Antibodies)l Cx50 function require (show TJP1 Antibodies)s an intact PDZ domain-binding motif.

  8. These results showed that the binding of calcium/calmodulin (show Calm2 Antibodies) to the intracellular loop of connexin 50 (Cx50) is critical for mediating the Ca2 (show CA2 Antibodies)+-dependent inhibition of Cx50 gap junctions

  9. Dense cataract and microphthalmia (dcm) in BALB/c mice is caused by mutations in the GJA8 gene.

  10. The N terminus of Cx50 is critical for both the V(j)-gating and the gamma(j), and the introduction of a positively charged Arg at the ninth position reduced the G(min) with a correlated disappearance of the substate at the single channel level.

Human Gap Junction Protein, alpha 8, 50kDa (GJA8) interaction partners

  1. This study identified three mutations in three Chinese families with hereditary cataracts. Of the three mutations, two were novel (c.125 A > C in GJA3 (show GJA3 Antibodies) and c.268 C > T in GJA3 (show GJA3 Antibodies)), one was previously reported (c.218 C > T in GJA8).

  2. These results indicated that the mutant Cx50 (S276F) might inhibit the function of gap junction channel in a dominant negative manner, but inhibit the hemichannel function in a recessive negative manner.

  3. GJA8 mutation (p.V44A) is associated with autosomal dominant congenital cataract.

  4. This is a novel missense mutation [c.829C > T, (p.H277Y)] identified in exon 2 of Cx50.

  5. We have used trio (show TRIO Antibodies)-based exome sequencing to uncover a recurrent missense mutation in CRYGD (show CRYGD Antibodies) and two novel missense mutations in GJA8 associated with autosomal dominant cataract (show MIP Antibodies) in three nuclear families.

  6. Tthe molecular consequences of the p.P88T mutation in GJA8 include changes in connexin 50 protein localization patterns.

  7. A recurrent missense mutation c.773C>T (p.S258F) in exon 2 of the gap junction protein alpha 8 gene (GJA8) was identified in the proband with nuclear cataract.

  8. structural bases of the varied functional consequences of Cx50 missense mutations, were determined.

  9. Exome sequencing in developmental eye disease leads to identification of causal variants in GJA8, CRYGC (show CRYGC Antibodies), PAX6 (show PAX6 Antibodies) and CYP1B1 (show CYP1B1 Antibodies).

  10. The results provide a molecular basis for the formation of various cataract phenotypes in human patients with Cx50 mutations.

Gap Junction Protein, alpha 8, 50kDa (GJA8) Antigen Profile

Protein Summary

This gene encodes a transmembrane connexin protein that is necessary for lens growth and maturation of lens fiber cells. The encoded protein is a component of gap junction channels and functions in a calcium and pH-dependent manner. Mutations in this gene have been associated with zonular pulverulent cataracts, nuclear progressive cataracts, and cataract-microcornea syndrome.

Gene names and symbols associated with GJA8

  • gap junction protein, alpha 8 (Gja8) antibody
  • gap junction protein, alpha 8, 50kDa (GJA8) antibody
  • Aey5 antibody
  • CAE antibody
  • CAE1 antibody
  • Cnx50 antibody
  • CTRCT1 antibody
  • Cx45.6 antibody
  • CX50 antibody
  • CZP1 antibody
  • Lop10 antibody
  • MP70 antibody

Protein level used designations for GJA8

alpha 8 connexin , connexin-50 , gap junction alpha-8 protein , gap junction membrane channel protein alpha 8 , lens fiber protein MP70 , lens opacity 10 , connexin 50 , cell surface glycoprotein , gap junction membrane channel protein alpha-8 , lens intrinsic membrane protein MP70 , connexin 45.6 , connexin-45.6 , MP38 , MP64 , connexin-49 , cx49

GENE ID SPECIES
14616 Mus musculus
29601 Rattus norvegicus
2703 Homo sapiens
395846 Gallus gallus
100170231 Ovis aries
483156 Canis lupus familiaris
524042 Bos taurus
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