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Gap Junction Protein, alpha 8, 50kDa Proteins (GJA8)

GJA8 encodes a transmembrane connexin protein that is necessary for lens growth and maturation of lens fiber cells. Additionally we are shipping Gap Junction Protein, alpha 8, 50kDa Antibodies (51) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GJA8 14616 P28236
Rat GJA8 GJA8 29601  
GJA8 2703 P48165
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Top Gap Junction Protein, alpha 8, 50kDa Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
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Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
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HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

GJA8 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , , ,
, ,

More Proteins for Gap Junction Protein, alpha 8, 50kDa (GJA8) Interaction Partners

Mouse (Murine) Gap Junction Protein, alpha 8, 50kDa (GJA8) interaction partners

  1. Study showed that mouse horizontal cells establish a coupled dendritic network by Cx57 and two coupled axon terminal networks, one made of Cx50 and the other made of Cx57 channels

  2. data show that expression and phosphorylation of Cx46 (show GJA3 Proteins) and Cx50 are complementary in seminiferous tubules

  3. demonstrate, at the whole gap junction channel level, a crucial role of the surface charge properties in the first transmembrane/first extracellular border domain in determining the efficiency of ion permeation and the Vj gating of Cx50

  4. Data show that Ca(V) 1.2 and 1.3 channels are expressed in lens, regulating phosphorylation of aquaporin-0 and myosin light chain and expression of connexins 50 and 46.

  5. The Gja8(R205G) mutation differentially impairs the functions of Cx50 and Cx46 (show GJA3 Proteins) to cause cataracts, small lenses and microphthalmia.

  6. D3 residue plays an essential role in unitary conductance of Cx50 gap junction channels

  7. Normal Cx50 function require (show TJP1 Proteins)s an intact PDZ domain-binding motif.

  8. These results showed that the binding of calcium/calmodulin (show Calm2 Proteins) to the intracellular loop of connexin 50 (Cx50) is critical for mediating the Ca2 (show CA2 Proteins)+-dependent inhibition of Cx50 gap junctions

  9. Dense cataract and microphthalmia (dcm) in BALB/c mice is caused by mutations in the GJA8 gene.

  10. The N terminus of Cx50 is critical for both the V(j)-gating and the gamma(j), and the introduction of a positively charged Arg at the ninth position reduced the G(min) with a correlated disappearance of the substate at the single channel level.

Human Gap Junction Protein, alpha 8, 50kDa (GJA8) interaction partners

  1. This study identified three mutations in three Chinese families with hereditary cataracts. Of the three mutations, two were novel (c.125 A > C in GJA3 (show GJA3 Proteins) and c.268 C > T in GJA3 (show GJA3 Proteins)), one was previously reported (c.218 C > T in GJA8).

  2. These results indicated that the mutant Cx50 (S276F) might inhibit the function of gap junction channel in a dominant negative manner, but inhibit the hemichannel function in a recessive negative manner.

  3. GJA8 mutation (p.V44A) is associated with autosomal dominant congenital cataract.

  4. This is a novel missense mutation [c.829C > T, (p.H277Y)] identified in exon 2 of Cx50.

  5. We have used trio-based exome sequencing to uncover a recurrent missense mutation in CRYGD and two novel missense mutations in GJA8 associated with autosomal dominant cataract in three nuclear families.

  6. Tthe molecular consequences of the p.P88T mutation in GJA8 include changes in connexin 50 protein localization patterns.

  7. A recurrent missense mutation c.773C>T (p.S258F) in exon 2 of the gap junction protein alpha 8 gene (GJA8) was identified in the proband with nuclear cataract.

  8. structural bases of the varied functional consequences of Cx50 missense mutations, were determined.

  9. Exome sequencing in developmental eye disease leads to identification of causal variants in GJA8, CRYGC (show CRYGC Proteins), PAX6 (show PAX6 Proteins) and CYP1B1 (show CYP1B1 Proteins).

  10. The results provide a molecular basis for the formation of various cataract phenotypes in human patients with Cx50 mutations.

Gap Junction Protein, alpha 8, 50kDa (GJA8) Protein Profile

Protein Summary

This gene encodes a transmembrane connexin protein that is necessary for lens growth and maturation of lens fiber cells. The encoded protein is a component of gap junction channels and functions in a calcium and pH-dependent manner. Mutations in this gene have been associated with zonular pulverulent cataracts, nuclear progressive cataracts, and cataract-microcornea syndrome.

Gene names and symbols associated with GJA8

  • gap junction protein, alpha 8 (Gja8)
  • gap junction protein, alpha 8, 50kDa (GJA8)
  • Aey5 protein
  • CAE protein
  • CAE1 protein
  • Cnx50 protein
  • CTRCT1 protein
  • Cx45.6 protein
  • CX50 protein
  • CZP1 protein
  • Lop10 protein
  • MP70 protein

Protein level used designations for GJA8

alpha 8 connexin , connexin-50 , gap junction alpha-8 protein , gap junction membrane channel protein alpha 8 , lens fiber protein MP70 , lens opacity 10 , connexin 50 , cell surface glycoprotein , gap junction membrane channel protein alpha-8 , lens intrinsic membrane protein MP70 , connexin 45.6 , connexin-45.6 , MP38 , MP64 , connexin-49 , cx49

GENE ID SPECIES
14616 Mus musculus
29601 Rattus norvegicus
2703 Homo sapiens
395846 Gallus gallus
100170231 Ovis aries
483156 Canis lupus familiaris
524042 Bos taurus
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