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component of gap junctions, which connect the cytoplasm of adjacent cells; involved in intercellular transport of small hydrophilic molecules; facilitates cell-cell communication.
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We show that the cell-surface and secreted isoforms of CSF-1 (show CSF1 ELISA Kits) have opposing effects on macrophage activation and disease progression in a mouse model of connexin32-deficientconnexin32-deficient mice
Results identify CSF-1 (show CSF1 ELISA Kits)-activated macrophages as crucial mediators of detrimental Schwann cell dedifferentiation in Cx32-deficient mice
Blockade of endothelial Cx32 increased tissue factor (show F3 ELISA Kits) expression induced by TNF-alpha (show TNF ELISA Kits) stimulation and cell-cell interaction via ICAM1 (show ICAM1 ELISA Kits). Direct Cx32-mediated interaction modulates TF expression in ECs during vascular inflammation.
These findings support a role for Cx32 in non-myelinating and regenerating populations of Schwann cells in normal axonal maintenance in re-myelination, and regeneration of peripheral nerve following injury
Connexin32 interacts with connexin26 (show GJB2 ELISA Kits) and the mitochondrial protein (show COX6B2 ELISA Kits), sideroflexin-1 (show SFXN1 ELISA Kits), at the plasma membrane forming a novel signaling nexus.
These results demonstrate that the incidence of hepatocellular carcinoma increases only in male Cx32KO mice, presumably due to enhanced tumor promotion and progression signals associated with Cx32 deficiency.
Cx32 is differentially phosphorylated and exists in a complex with SAP97 (show DLG1 ELISA Kits) and CaM.
Cx32 therapy improves gap junctional conductance results in larger infarct size, and no antiarrhythmic efficacy.
Connexin 36 (show GJD2 ELISA Kits) is expressed in beta and connexins 26 and 32 in acinar cells at the end of the secondary transition of mouse pancreatic development and increase during fetal and perinatal life.
Data show that absence of connexin30 in knockout mice changes the expression patterns of connexin26 (show GJB2 ELISA Kits) and connexin32 in glial cells and leptomeninges.
component of gap junctions, which connect the cytoplasm of adjacent cells; involved in intercellular transport of small hydrophilic molecules; facilitates cell-cell communication
, gap junction beta-1 protein
, gap junction membrane channel protein beta 1
, GAP junction 28 kDa liver protein
, gap junction protein, beta 1, 32kDa
, gap junction protein beta 1