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Gap Junction Protein, beta 6, 30kDa Proteins (GJB6)

Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. Additionally we are shipping GJB6 Antibodies (51) and GJB6 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GJB6 14623 P70689
Rat GJB6 GJB6 84403  
GJB6 10804 O95452
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Top GJB6 Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days

GJB6 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,

More Proteins for Gap Junction Protein, beta 6, 30kDa (GJB6) Interaction Partners

Mouse (Murine) Gap Junction Protein, beta 6, 30kDa (GJB6) interaction partners

  1. Connexin 30, but not connexin 43, hemichannels close upon protein kinase C activation, illustrating that connexin hemichannels display not only isoform-specific permeability profiles but also isoform-specific regulation by protein kinase C.

  2. presence of Cx30 in the cochlea does not compensate for Cx26 (show GJB2 Proteins) loss, and the absence of both connexins from vestibular sensory epithelia is no more injurious than the absence of one of them

  3. four unique Cx30 mutants might cause disease through different mechanisms that also likely include their selective trans-dominant effects on coexpressed connexins.

  4. The cortex modafinil injection increases the expression of mRNA and protein of connexin 30.

  5. Our data reveal that Cx43 (show GJA1 Proteins) promotes the survival of newborn neurons in the adult mouse hippocampus whereas Cx30 restricts their survival.

  6. The observations demonstrate a role for Cx30 and intercellular communication in regulating repair responses in an epithelial tissue.

  7. We showed co-expression of Cx30 and p63 (show CKAP4 Proteins) in developing mouse hair follicles and nail (show CD244 Proteins) units.

  8. in the Cx30 knock-out mouse model, defective Cx26 (show GJB2 Proteins) expression is the likely cause of deafness, and in contrast to current opinion, Cx30 is dispensable for cochlear functions

  9. These results demonstrate that astroglial connexins are necessary to maintain BBB integrity.

  10. This study demonistrated that Cx30/Cx47 (show GJC2 Proteins) double-deficient mice has the functional role of both connexins for interastrocytic, interoligodendrocytic, and panglial coupling, and show that both connexins are required for maintenance of myelin.

Human Gap Junction Protein, beta 6, 30kDa (GJB6) interaction partners

  1. identification and functional characterization of a new Cx30 mutation in a family with hearing impairment in association with previously unreported skin anomalies

  2. Screening of GJB6 gene large deletions among Syrians with congenital hearing impairment.

  3. Periostin (show POSTN Proteins) is a robust marker of glioma malignancy and potential tumor recurrence. Abrogation of glioma stem cell tumorigenicity after periostin (show POSTN Proteins) inhibition provides support for exploring the therapeutic impact of targeting periostin (show POSTN Proteins).

  4. results suggest that SNPs present in the GJB2 (show GJB2 Proteins) and GJB6 genes may have an influence on ARNSHL in humans.

  5. found that connexin 26 (Cx26 (show GJB2 Proteins)) and Cx30 GJs readily diffuse within the plaque structures, whereas Cx43 (show GJA1 Proteins) GJs remain persistently immobile for more than 2 min after bleaching

  6. GJB6 deletions were not detected.

  7. An absence of GJB6 mutations and low frequency of SLC26A4 (show SLC26A4 Proteins) mutations suggest that additional genetic factors may contribute to nonsyndromic hearing loss in India.

  8. Results show high mRNA and protein levels for Cx43 (show GJA1 Proteins) and Cx30 in breast cancer but they are correlated with improved and bad outcome respectively suggesting that they may serve as prognostic markers in breast cancer.

  9. Mutations in GJB2 (show GJB2 Proteins), GJB6 and GJA1 (show GJA1 Proteins) are not a major cause of non-syndromic deafness in black Africans

  10. study found A c.31G>A (p.G11R) missense mutation in GJB6 gene is the genotypic characteristic for hidrotic ectodermal dysplasia in Chinese population

GJB6 Protein Profile

Protein Summary

Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia.

Gene names and symbols associated with GJB6

  • connexin 30 (LOC387566)
  • gap junction protein, beta 2, 26kDa (gjb2)
  • gap junction protein, beta 6, 30kDa (GJB6)
  • gap junction protein, beta 6 (Gjb6)
  • AA958971 protein
  • connexin-26 protein
  • cx26 protein
  • CX30 protein
  • CX31 protein
  • D14Bwg0506e protein
  • DFNA3 protein
  • dfna3a protein
  • DFNA3B protein
  • dfnb1 protein
  • dfnb1a protein
  • DFNB1B protein
  • ECTD2 protein
  • ED2 protein
  • EDH protein
  • gjb6 protein
  • HED protein
  • HED2 protein
  • nsrd1 protein
  • ppk protein

Protein level used designations for GJB6

connexin 30 , connexin 26 , gap junction beta-2 protein , gap junction protein, beta 6, 30kDa , connexin-30 , gap junction beta-6 protein , gap junction membrane channel protein beta 6 , gap junction protein, beta 6 (connexin 30) , ectodermal dysplasia 2, hidrotic (Clouston syndrome) , connexin 31 , connexin-31

387566 Xenopus laevis
549738 Xenopus (Silurana) tropicalis
704105 Macaca mulatta
14623 Mus musculus
84403 Rattus norvegicus
10804 Homo sapiens
508454 Bos taurus
395771 Gallus gallus
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