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anti-Gap Junction Protein, gamma 2, 47kDa (GJC2) Antibodies

GJC2 encodes a gap junction protein. Additionally we are shipping Gap Junction Protein, gamma 2, 47kDa Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GJC2 118454 Q8BQU6
GJC2 497913 Q80XF7
GJC2 57165 Q5T442
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Top anti-Gap Junction Protein, gamma 2, 47kDa Antibodies at antibodies-online.com

Showing 10 out of 33 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-GJC2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: MCF7 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Mouse Un-conjugated WB GJC2 Antibody (N-term)  western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the GJC2 antibody detected the GJC2 protein (arrow). 0.1 mL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated WB GJC2 Antibody (N-term)  western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the GJC2 antibody detected the GJC2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 14 Days
$369.79
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Mouse Un-conjugated WB 0.1 mL Log in to see 6 Days
$457.14
Details
Human Rabbit Un-conjugated IF, ELISA, WB 100 μg Log in to see 11 to 16 Days
$412.86
Details
Human Mouse Un-conjugated WB 100 μL Log in to see 8 to 10 Days
$463.83
Details

GJC2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine) ,
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Rat (Rattus) ,


Human ,
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Top referenced anti-Gap Junction Protein, gamma 2, 47kDa Antibodies

  1. Human Polyclonal GJC2 Primary Antibody for WB - ABIN2774865 : Henneke, Combes, Diekmann, Bertini, Brockmann, Burlina, Kaiser, Ohlenbusch, Plecko, Rodriguez, Boespflug-Tanguy, Gärtner: GJA12 mutations are a rare cause of Pelizaeus-Merzbacher-like disease. in Neurology 2008 (PubMed)

More Antibodies against Gap Junction Protein, gamma 2, 47kDa Interaction Partners

Mouse (Murine) Gap Junction Protein, gamma 2, 47kDa (GJC2) interaction partners

  1. Data show that segregation of Foxc2 (show FOXC2 Antibodies) and NFATc1 (show NFATC1 Antibodies) transcription factor is closely associated with the highly polarized expression of connexins Cx37 (show GJA4 Antibodies), Cx43 (show GJA1 Antibodies), and Cx47.

  2. This study demonistrated that Cx30 (show GJB6 Antibodies)/Cx47 double-deficient mice has the functional role of both connexins for interastrocytic, interoligodendrocytic, and panglial coupling, and show that both connexins are required for maintenance of myelin.

  3. PMLD1 (Pelizaeus-Merzbacher-like disease 1) is caused by the loss of Cx47 channel function that results in impaired panglial coupling in white matter tissue.

  4. oligodendrocyte-astrocyte gap junction coupling in Cx32 (show GJB1 Antibodies) or Cx47 knockout mice. In the neocortex, oligodendrocytes appeared to be directly and exclusively coupled to astrocytes; Cx47, but not Cx32 (show GJB1 Antibodies), was required for O:A coupling.

  5. oligodendrocytes in white matter form a functional syncytium predominantly among each other dependent on Cx47 and Cx32 (show GJB1 Antibodies) expression, while astrocytic connexins expression can promote the size of this network

  6. Cx47-deficient mice revealed a vacuolation of nerve fibers at the site of the optic nerve where axons are first contacted by oligodendrocytes and myelination starts; Cx32 (show GJB1 Antibodies)/Cx47-double-deficient mice developed action tremor and died ca 51 d after birth

  7. Mice lacking either Cx47 or Cx32 (show GJB1 Antibodies) are viable but mice lacking both connexins die by postnatal week 6 from CNS myelin sheath abnormalities, vacuolation, enlarged periaxonal collars, oligodendrocyte cell death, and axonal loss

  8. All oligodendrocytes appear to express Cx47, which is largely restricted to their perikarya

  9. These results demonstrate MUPP1 (show MPDZ Antibodies) at O/A gap junctions and Cx47-dependent targeting of connexins to the plasma membranes of oligodendrocyte somata.

Human Gap Junction Protein, gamma 2, 47kDa (GJC2) interaction partners

  1. GJC2 promoter region mutation screening should be included in the evaluation of patients with unexplained hypomyelinating leukodystrophies.

  2. we provide evidence that a mutation in GJA1 (show GJA1 Antibodies) leads not only to ODD as already described in the literature, but can also lead to lymphoedema as an associated feature.

  3. a novel homozygous mutation in GJC2 was identified in a 21-year-old female patient with Pelizaeus-Merzbacher-like disease

  4. This study identified novel chromosomal rearrangements proximal and distal to, and exclusive of the PLP1 (show PLP1 Antibodies) gene, showed equal frequencies of PLP1 (show PLP1 Antibodies) and GJA12/GJC2 mutations

  5. Most of the Pelizaeus-Merzbacher-like disease (PMLD)-linked Cx47 mutants disrupt Cx47/Cx47 and Cx47/Cx43 (show GJA1 Antibodies) GJ function in the glial network, which may play a role in leading to PMLD symptoms

  6. the extremely severe clinical Pelizaeus-Merzbacher-like disease form likely correlates with the predicted impairment of gap junction channel assembly resulting from the detrimental effect of the new p.Glu260Lys mutant allele on Cx47 protein

  7. founder mutation c.-167A>G localized in the GJC2 protein promoter region in patients with Pelizaeus Merzbacher disease and Pelizaeus Merzbacher like disease

  8. Cx47 mutations were identified in individuals having secondary lymphedema following breast cancer treatment; these novel mutations are dysfunctional and provide evidence that altered gap junction function leads to lymphedema

  9. We report the identification of the GJC2 promoter mutation (c.-167A>G) in nine patients from three unrelated Pakistani families with Pelizaeus-Merzbacher-like disease. Linkage analysis was consistent with a likely founder effect of this mutation

  10. Mutations within the GJC2 gene are associated with primary lymphoedema.

Cow (Bovine) Gap Junction Protein, gamma 2, 47kDa (GJC2) interaction partners

  1. AQP-0 (show MIP Antibodies) and connexins can be segregated in the membrane by protein-lipid interactions as modified by AQP-0 (show MIP Antibodies) homo-oligomerization

Gap Junction Protein, gamma 2, 47kDa (GJC2) Antigen Profile

Protein Summary

This gene encodes a gap junction protein. Gap junction proteins are members of a large family of homologous connexins and comprise 4 transmembrane, 2 extracellular, and 3 cytoplasmic domains. This gene plays a key role in central myelination and is involved in peripheral myelination in humans. Defects in this gene are the cause of autosomal recessive Pelizaeus-Merzbacher-like disease-1.

Gene names and symbols associated with GJC2

  • gap junction protein, gamma 2, 47kDa (GJC2) antibody
  • gap junction protein, gamma 2, 47kDa (gjc2) antibody
  • si:dkey-91f15.1 (si:dkey-91f15.1) antibody
  • gap junction protein, gamma 2 (Gjc2) antibody
  • B230382L12Rik antibody
  • CX46.6 antibody
  • Cx47 antibody
  • Gja12 antibody
  • HLD2 antibody
  • LMPH1C antibody
  • MGC146420 antibody
  • PMLDAR antibody
  • SPG44 antibody

Protein level used designations for GJC2

gap junction protein, gamma 2, 47kDa , connexin46.6 , gap junction protein, alpha 12, 47kDa , gap junction protein, gamma 12, 47kDa , connexin 46.6 , connexin 44.2 , connexin 47 type A , connexin 47 type C , connexin 47 type D , connexin-47 , gap junction alpha-12 protein , gap junction gamma-2 protein , gap junction membrane channel protein alpha 12 , gap junction protein, chi 2 , gap junction protein, alpha 12 , connexin-46.6

GENE ID SPECIES
695161 Macaca mulatta
739535 Pan troglodytes
779802 Xenopus (Silurana) tropicalis
100034658 Danio rerio
118454 Mus musculus
497913 Rattus norvegicus
57165 Homo sapiens
538745 Bos taurus
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