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Gap Junction Protein, gamma 2, 47kDa (GJC2) ELISA Kits

GJC2 encodes a gap junction protein. Additionally we are shipping Gap Junction Protein, gamma 2, 47kDa Antibodies (32) and Gap Junction Protein, gamma 2, 47kDa Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse GJC2 GJC2 118454 Q8BQU6
Anti-Rat GJC2 GJC2 497913 Q80XF7
Anti-Human GJC2 GJC2 57165 Q5T442
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More ELISA Kits for Gap Junction Protein, gamma 2, 47kDa Interaction Partners

Mouse (Murine) Gap Junction Protein, gamma 2, 47kDa (GJC2) interaction partners

  1. Data show that segregation of Foxc2 (show FOXC2 ELISA Kits) and NFATc1 (show NFATC1 ELISA Kits) transcription factor is closely associated with the highly polarized expression of connexins Cx37 (show GJA4 ELISA Kits), Cx43 (show GJA1 ELISA Kits), and Cx47.

  2. This study demonistrated that Cx30 (show GJB6 ELISA Kits)/Cx47 double-deficient mice has the functional role of both connexins for interastrocytic, interoligodendrocytic, and panglial coupling, and show that both connexins are required for maintenance of myelin.

  3. PMLD1 (Pelizaeus-Merzbacher-like disease 1) is caused by the loss of Cx47 channel function that results in impaired panglial coupling in white matter tissue.

  4. oligodendrocyte-astrocyte gap junction coupling in Cx32 (show GJB1 ELISA Kits) or Cx47 knockout mice. In the neocortex, oligodendrocytes appeared to be directly and exclusively coupled to astrocytes; Cx47, but not Cx32 (show GJB1 ELISA Kits), was required for O:A coupling.

  5. oligodendrocytes in white matter form a functional syncytium predominantly among each other dependent on Cx47 and Cx32 (show GJB1 ELISA Kits) expression, while astrocytic connexins expression can promote the size of this network

  6. Cx47-deficient mice revealed a vacuolation of nerve fibers at the site of the optic nerve where axons are first contacted by oligodendrocytes and myelination starts; Cx32 (show GJB1 ELISA Kits)/Cx47-double-deficient mice developed action tremor and died ca 51 d after birth

  7. Mice lacking either Cx47 or Cx32 (show GJB1 ELISA Kits) are viable but mice lacking both connexins die by postnatal week 6 from CNS myelin sheath abnormalities, vacuolation, enlarged periaxonal collars, oligodendrocyte cell death, and axonal loss

  8. All oligodendrocytes appear to express Cx47, which is largely restricted to their perikarya

  9. These results demonstrate MUPP1 (show MPDZ ELISA Kits) at O/A gap junctions and Cx47-dependent targeting of connexins to the plasma membranes of oligodendrocyte somata.

Human Gap Junction Protein, gamma 2, 47kDa (GJC2) interaction partners

  1. GJC2 promoter region mutation screening should be included in the evaluation of patients with unexplained hypomyelinating leukodystrophies.

  2. we provide evidence that a mutation in GJA1 (show GJA1 ELISA Kits) leads not only to ODD as already described in the literature, but can also lead to lymphoedema as an associated feature.

  3. a novel homozygous mutation in GJC2 was identified in a 21-year-old female patient with Pelizaeus-Merzbacher-like disease

  4. This study identified novel chromosomal rearrangements proximal and distal to, and exclusive of the PLP1 (show PLP1 ELISA Kits) gene, showed equal frequencies of PLP1 (show PLP1 ELISA Kits) and GJA12/GJC2 mutations

  5. Most of the Pelizaeus-Merzbacher-like disease (PMLD)-linked Cx47 mutants disrupt Cx47/Cx47 and Cx47/Cx43 (show GJA1 ELISA Kits) GJ function in the glial network, which may play a role in leading to PMLD symptoms

  6. the extremely severe clinical Pelizaeus-Merzbacher-like disease form likely correlates with the predicted impairment of gap junction channel assembly resulting from the detrimental effect of the new p.Glu260Lys mutant allele on Cx47 protein

  7. founder mutation c.-167A>G localized in the GJC2 protein promoter region in patients with Pelizaeus Merzbacher disease and Pelizaeus Merzbacher like disease

  8. Cx47 mutations were identified in individuals having secondary lymphedema following breast cancer treatment; these novel mutations are dysfunctional and provide evidence that altered gap junction function leads to lymphedema

  9. We report the identification of the GJC2 promoter mutation (c.-167A>G) in nine patients from three unrelated Pakistani families with Pelizaeus-Merzbacher-like disease. Linkage analysis was consistent with a likely founder effect of this mutation

  10. Mutations within the GJC2 gene are associated with primary lymphoedema.

Cow (Bovine) Gap Junction Protein, gamma 2, 47kDa (GJC2) interaction partners

  1. AQP-0 (show MIP ELISA Kits) and connexins can be segregated in the membrane by protein-lipid interactions as modified by AQP-0 (show MIP ELISA Kits) homo-oligomerization

Gap Junction Protein, gamma 2, 47kDa (GJC2) Antigen Profile

Antigen Summary

This gene encodes a gap junction protein. Gap junction proteins are members of a large family of homologous connexins and comprise 4 transmembrane, 2 extracellular, and 3 cytoplasmic domains. This gene plays a key role in central myelination and is involved in peripheral myelination in humans. Defects in this gene are the cause of autosomal recessive Pelizaeus-Merzbacher-like disease-1.

Gene names and symbols associated with GJC2

  • gap junction protein, gamma 2, 47kDa (GJC2) antibody
  • gap junction protein, gamma 2, 47kDa (gjc2) antibody
  • si:dkey-91f15.1 (si:dkey-91f15.1) antibody
  • gap junction protein, gamma 2 (Gjc2) antibody
  • B230382L12Rik antibody
  • CX46.6 antibody
  • Cx47 antibody
  • Gja12 antibody
  • HLD2 antibody
  • LMPH1C antibody
  • MGC146420 antibody
  • PMLDAR antibody
  • SPG44 antibody

Protein level used designations for GJC2

gap junction protein, gamma 2, 47kDa , connexin46.6 , gap junction protein, alpha 12, 47kDa , gap junction protein, gamma 12, 47kDa , connexin 46.6 , connexin 44.2 , connexin 47 type A , connexin 47 type C , connexin 47 type D , connexin-47 , gap junction alpha-12 protein , gap junction gamma-2 protein , gap junction membrane channel protein alpha 12 , gap junction protein, chi 2 , gap junction protein, alpha 12 , connexin-46.6

GENE ID SPECIES
695161 Macaca mulatta
739535 Pan troglodytes
779802 Xenopus (Silurana) tropicalis
100034658 Danio rerio
118454 Mus musculus
497913 Rattus norvegicus
57165 Homo sapiens
538745 Bos taurus
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