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Gap Junction Protein, gamma 2, 47kDa Proteins (GJC2)

GJC2 encodes a gap junction protein. Additionally we are shipping Gap Junction Protein, gamma 2, 47kDa Antibodies (32) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GJC2 118454 Q8BQU6
Rat GJC2 GJC2 497913 Q80XF7
GJC2 57165 Q5T442
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Top Gap Junction Protein, gamma 2, 47kDa Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
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Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
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Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
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HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details

GJC2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
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Human ,
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More Proteins for Gap Junction Protein, gamma 2, 47kDa (GJC2) Interaction Partners

Mouse (Murine) Gap Junction Protein, gamma 2, 47kDa (GJC2) interaction partners

  1. Data show that segregation of Foxc2 (show FOXC2 Proteins) and NFATc1 (show NFATC1 Proteins) transcription factor is closely associated with the highly polarized expression of connexins Cx37 (show GJA4 Proteins), Cx43 (show GJA1 Proteins), and Cx47.

  2. This study demonistrated that Cx30 (show GJB6 Proteins)/Cx47 double-deficient mice has the functional role of both connexins for interastrocytic, interoligodendrocytic, and panglial coupling, and show that both connexins are required for maintenance of myelin.

  3. PMLD1 (Pelizaeus-Merzbacher-like disease 1) is caused by the loss of Cx47 channel function that results in impaired panglial coupling in white matter tissue.

  4. oligodendrocyte-astrocyte gap junction coupling in Cx32 (show GJB1 Proteins) or Cx47 knockout mice. In the neocortex, oligodendrocytes appeared to be directly and exclusively coupled to astrocytes; Cx47, but not Cx32 (show GJB1 Proteins), was required for O:A coupling.

  5. oligodendrocytes in white matter form a functional syncytium predominantly among each other dependent on Cx47 and Cx32 (show GJB1 Proteins) expression, while astrocytic connexins expression can promote the size of this network

  6. Cx47-deficient mice revealed a vacuolation of nerve fibers at the site of the optic nerve where axons are first contacted by oligodendrocytes and myelination starts; Cx32 (show GJB1 Proteins)/Cx47-double-deficient mice developed action tremor and died ca 51 d after birth

  7. Mice lacking either Cx47 or Cx32 (show GJB1 Proteins) are viable but mice lacking both connexins die by postnatal week 6 from CNS myelin sheath abnormalities, vacuolation, enlarged periaxonal collars, oligodendrocyte cell death, and axonal loss

  8. All oligodendrocytes appear to express Cx47, which is largely restricted to their perikarya

  9. These results demonstrate MUPP1 at O/A gap junctions and Cx47-dependent targeting of connexins to the plasma membranes of oligodendrocyte somata.

Human Gap Junction Protein, gamma 2, 47kDa (GJC2) interaction partners

  1. GJC2 promoter region mutation screening should be included in the evaluation of patients with unexplained hypomyelinating leukodystrophies.

  2. we provide evidence that a mutation in GJA1 (show GJA1 Proteins) leads not only to ODD as already described in the literature, but can also lead to lymphoedema as an associated feature.

  3. a novel homozygous mutation in GJC2 was identified in a 21-year-old female patient with Pelizaeus-Merzbacher-like disease

  4. This study identified novel chromosomal rearrangements proximal and distal to, and exclusive of the PLP1 (show PLP1 Proteins) gene, showed equal frequencies of PLP1 (show PLP1 Proteins) and GJA12/GJC2 mutations

  5. Most of the Pelizaeus-Merzbacher-like disease (PMLD)-linked Cx47 mutants disrupt Cx47/Cx47 and Cx47/Cx43 (show GJA1 Proteins) GJ function in the glial network, which may play a role in leading to PMLD symptoms

  6. the extremely severe clinical Pelizaeus-Merzbacher-like disease form likely correlates with the predicted impairment of gap junction channel assembly resulting from the detrimental effect of the new p.Glu260Lys mutant allele on Cx47 protein

  7. founder mutation c.-167A>G localized in the GJC2 protein promoter region in patients with Pelizaeus Merzbacher disease and Pelizaeus Merzbacher like disease

  8. Cx47 mutations were identified in individuals having secondary lymphedema following breast cancer treatment; these novel mutations are dysfunctional and provide evidence that altered gap junction function leads to lymphedema

  9. We report the identification of the GJC2 promoter mutation (c.-167A>G) in nine patients from three unrelated Pakistani families with Pelizaeus-Merzbacher-like disease. Linkage analysis was consistent with a likely founder effect of this mutation

  10. Mutations within the GJC2 gene are associated with primary lymphoedema.

Cow (Bovine) Gap Junction Protein, gamma 2, 47kDa (GJC2) interaction partners

  1. AQP-0 and connexins can be segregated in the membrane by protein-lipid interactions as modified by AQP-0 homo-oligomerization

Gap Junction Protein, gamma 2, 47kDa (GJC2) Protein Profile

Protein Summary

This gene encodes a gap junction protein. Gap junction proteins are members of a large family of homologous connexins and comprise 4 transmembrane, 2 extracellular, and 3 cytoplasmic domains. This gene plays a key role in central myelination and is involved in peripheral myelination in humans. Defects in this gene are the cause of autosomal recessive Pelizaeus-Merzbacher-like disease-1.

Gene names and symbols associated with GJC2

  • gap junction protein, gamma 2, 47kDa (GJC2)
  • gap junction protein, gamma 2, 47kDa (gjc2)
  • si:dkey-91f15.1 (si:dkey-91f15.1)
  • gap junction protein, gamma 2 (Gjc2)
  • B230382L12Rik protein
  • CX46.6 protein
  • Cx47 protein
  • Gja12 protein
  • HLD2 protein
  • LMPH1C protein
  • MGC146420 protein
  • PMLDAR protein
  • SPG44 protein

Protein level used designations for GJC2

gap junction protein, gamma 2, 47kDa , connexin46.6 , gap junction protein, alpha 12, 47kDa , gap junction protein, gamma 12, 47kDa , connexin 46.6 , connexin 44.2 , connexin 47 type A , connexin 47 type C , connexin 47 type D , connexin-47 , gap junction alpha-12 protein , gap junction gamma-2 protein , gap junction membrane channel protein alpha 12 , gap junction protein, chi 2 , gap junction protein, alpha 12 , connexin-46.6

GENE ID SPECIES
695161 Macaca mulatta
739535 Pan troglodytes
779802 Xenopus (Silurana) tropicalis
100034658 Danio rerio
118454 Mus musculus
497913 Rattus norvegicus
57165 Homo sapiens
538745 Bos taurus
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