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Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog Proteins (FGR)

FGR is a member of the Src family of protein tyrosine kinases (PTKs). Additionally we are shipping Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog Antibodies (125) and Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FGR 79114 Q04589
FGR 2268 P09769
FGR 14191 P14234
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Top Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human Un-conjugated 5 μg Log in to see 2 to 3 Days
$336.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,468.67
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Baculovirus Human GST-His-Tag Recombinant FGR protein tested by SDS-PAGE gel. 0.5 µg of FGR protein was analyzed using SDS/PAGE followed by Western blot with either an anti-FGR or anti-GST antibody. 10 μg Log in to see 1 to 2 Days
$443.33
Details
HOST_Sf-9 cells Human Un-conjugated   5 μg Log in to see 3 to 4 Days
$571.07
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

FGR Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus) ,

Human , , , , ,
, ,
Mouse (Murine)

More Proteins for Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) Interaction Partners

Human Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) interaction partners

  1. we provide evidence for involvement of HCK (show HCK Proteins) and FGR in FCRL4 (show FCRL4 Proteins)-mediated immunoregulation and for the functional importance of posttranslational modifications of the FCRL4 (show FCRL4 Proteins) molecule.

  2. Data indicate that combined treatment using SFK (LYN (show LYN Proteins), HCK (show HCK Proteins), or FGR) and c-KIT inhibitor dasatinib dasatinib and chemotherapy provides a novel approach to increasing p53 (show TP53 Proteins) activity and enhancing targeting of acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)) stem cells.

  3. Fgr plays a biologically significant role in ovarian cancer growth and might represent an important target

  4. Recruitment of the coactivator, SRC2 (show NCOA2 Proteins), is coupled to cooperative DNA binding by the progesterone receptor (show PGR Proteins).

Mouse (Murine) Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) interaction partners

  1. Data indicate that Src (show SRC Proteins)-Family Kinases Hck (show HCK Proteins) and Fgr regulate cytokine secretion by macrophages.

  2. Fgr is not only are progressively overexpressed in atherosclerosis, but it also controls critical molecular processes in monocyte influx, blood monocyte subset balance, macrophage accumulation, and the maintenance of atherosclerotic lesion stability.

  3. Ablation of Fgr abolishes the capacity of mitochondria to adjust metabolism upon nutrient restriction, hypoxia/reoxygenation, and T cell activation, demonstrating the physiological relevance of this adaptive response.

  4. The Src (show SRC Proteins) family kinases Hck (show HCK Proteins), Fgr, and Lyn (show LYN Proteins) are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.

  5. The Src family kinase Fgr is critical for activation of mast cells and IgE-mediated anaphylaxis in mice.

  6. Despite possessing enhanced killing, alveolar macrophage Fgr/Hck (show HCK Proteins)/Lyn (show LYN Proteins)-deficient ("triple-knockout") mice do not demonstrate enhanced inflammatory responses to Pneumocystis murina.

  7. Hck and Fgr function as negative regulators of myeloid cell chemokine signaling by maintaining the tonic phosphorylation of PIR-

  8. interaction of MIST (show CLNK Proteins) with Fgr, mediated by the C-terminal proline-rich region of MIST (show CLNK Proteins) and the SH3 domain of Fgr, was required for the suppression of NK-cell receptor (show KLRD1 Proteins)-induced IFN-gamma (show IFNG Proteins) production

  9. Fgr plays no role in chemoattractant-induced, inside-out beta 2 integrin activation of neutrophils but regulates their outside-in, signaling-dependent sustained adhesion.

  10. Data show that a pathway involving Fgr, DAP12 (show TYROBP Proteins) and FcRgamma (show FCER1G Proteins) is involved in the initial signaling events downstream of E-selectin (show SELE Proteins)-engaged PSGL-1 (show SELPLG Proteins) that are required to initiate neutrophil slow rolling.

Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) Protein Profile

Protein Summary

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene names and symbols associated with FGR

  • Fibroblast growth factor receptor 1 (Fgfr1)
  • Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog (FGR)
  • feline Gardner-Rasheed sarcoma viral oncogene (Fgr)
  • feline Gardner-Rasheed sarcoma viral oncogene homolog (FGR)
  • Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog (Fgr)
  • c-fgr protein
  • c-src2 protein
  • p55-Fgr protein
  • p55c-fgr protein
  • p58-Fgr protein
  • p58c-fgr protein
  • SRC2 protein

Protein level used designations for FGR

FGF receptor-1 , FGFR-1 , MFR , bFGF-R , bFGF-R-1 , basic fibroblast growth factor receptor 1 , c-fgr , fibroblast growth factor receptor 1 , proto-oncogene c-Fgr , tyrosine-protein kinase Fgr , proto-oncogene tyrosine-protein kinase FGR , Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog , tyrosine-protein kinase Fgr-like , Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog , proto-oncogene tyrosine-protein kinase Fgr , c-fgr protooncogene , c-src-2 proto-oncogene , p55-c-fgr protein , v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog , p55-Fgr

GENE ID SPECIES
79114 Rattus norvegicus
516133 Bos taurus
716296 Macaca mulatta
739516 Pan troglodytes
100442468 Pongo abelii
100467541 Ailuropoda melanoleuca
79113 Rattus norvegicus
2268 Homo sapiens
14191 Mus musculus
487341 Canis lupus familiaris
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