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GSDMB encodes a member of the gasdermin-domain containing protein family. Additionally we are shipping Gasdermin B Antibodies (40) and many more products for this protein.
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Based on our results and published findings on GSDMA, GSDMB, LRRC3C, and related proteins, we propose that this locus in part affects IBD susceptibility via effects on apoptosis and cell proliferation
GSDMB variants have been shown to be associated with Asthma in children with Rhinovirus infections -induced wheezing illnesses.
The GSDMB-driven HSVtk expression vector had a therapeutic effect on the occult peritoneal dissemination model mice.
Gasdermin-B promotes invasion and metastasis in breast cancer cells
Results confirmed the genetic association between GSDMB/ ORMDL3 (show ORMDL3 Proteins) and childhood asthma and show significant differences in the DNA methylation (show HELLS Proteins) levels of ORMDL3 (show ORMDL3 Proteins) promoter of asthmatic children.
3 SNPs associated with the fraction of exhaled nitric oxide in childhood asthma are rs3751972 in LYRM9; rs944722 in NOS2 (show NANOS2 Proteins); and rs8069176 near GSDMB; all at 17q12-q21.
rs11078928 is associated with the production of a novel GSDMB transcript lacking an internal segment
No association between GSDMB polymorphisms and rheumatoid arthritis was observed.
GSDMB SNP rs2305480 (Ser311Pro) was associated with asthma diagnosis (p = 8.9x10-4), bronchial hyperresponsiveness to methacholine (p = 8.2x10-4) and severity (p = 1.5x10-4) with supporting evidence from a second GSDMB SNP rs11078927 (intronic).
GSDMB/ORMDL3 (show ORMDL3 Proteins) variants contribute to asthma susceptibility and eosinophil-mediated bronchial hyperresponsiveness.
This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding.
, gasdermin-like protein