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GSDMB encodes a member of the gasdermin-domain containing protein family. Additionally we are shipping Gasdermin B Antibodies (23) and Gasdermin B Proteins (3) and many more products for this protein.
The rs8067378 SNP variants may increase the expression of GSDMB and the risk of the development and progression of cervical SCC (show CYP11A1 ELISA Kits).
GSDMB levels are significantly modulated by NMD. Importantly, both AS isoforms and the identified ecircRNA were significantly dysregulated in peripheral blood mononuclear cells of relapsing-remitting MS patients compared to controls.
We found strong associations among GSDMB polymorphisms and the presence of AERD and FEV1 in Korean patients with asthma. Our findings indicated that genetic variations of GSDMB may be associated with the development of AERD and aspirin-induced bronchospasm.
we investigated the association between GSDMA and GSDMB variants and the incidence of adult and childhood asthma among Jordanians.An association between the GSDMB T/C single nucleotide polymorphism (SNP) genotype and the incidence of childhood asthma was found
Based on our results and published findings on GSDMA, GSDMB, LRRC3C, and related proteins, we propose that this locus in part affects IBD susceptibility via effects on apoptosis and cell proliferation
GSDMB variants have been shown to be associated with Asthma in children with Rhinovirus infections -induced wheezing illnesses.
The GSDMB-driven HSVtk expression vector had a therapeutic effect on the occult peritoneal dissemination model mice.
Gasdermin-B promotes invasion and metastasis in breast cancer cells
Results confirmed the genetic association between GSDMB/ ORMDL3 (show ORMDL3 ELISA Kits) and childhood asthma and show significant differences in the DNA methylation (show HELLS ELISA Kits) levels of ORMDL3 (show ORMDL3 ELISA Kits) promoter of asthmatic children.
3 SNPs associated with the fraction of exhaled nitric oxide in childhood asthma are rs3751972 in LYRM9; rs944722 in NOS2; and rs8069176 near GSDMB; all at 17q12-q21.
This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding.
, gasdermin-like protein