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Gasdermin D is a member of the gasdermin family. Additionally we are shipping Gasdermin D Antibodies (33) and Gasdermin D Proteins (3) and many more products for this protein.
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Gene deletion of GSDMD demonstrated that GSDMD is required for pyroptosis and for the secretion but not proteolytic maturation of IL-1beta (show IL1B ELISA Kits) in both canonical and non-canonical inflammasome responses.
GSDMD N-terminal cleavage product oligomerizes in membranes to form pores that are visible by electron microscopy
caspase-1 and caspase-4/5/11 specifically cleaved the linker between the amino-terminal gasdermin-N and carboxy-terminal gasde (show DCLRE1C ELISA Kits)rmin-C domains in GSDM (show CASP4 ELISA Kits)D, which was re (show CASP1 ELISA Kits)quired and sufficient for pyroptosis
Study investigated the expression pattern of the GSDM family genes in the upper gastrointestinal epithelium and cancers.
identification of gasdermin D (Gsdmd) by genome-wide clustered regularly interspaced palindromic repeat (CRISPR)-Cas9 nuclease (show DCLRE1C ELISA Kits) screens of caspase-11 (show CASP4 ELISA Kits)- and caspase-1 (show CASP1 ELISA Kits)-mediated pyroptosis in mouse bone marrow macrophages
gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1beta maturation
This study clearly shows that Gsdmd is not essential for development of mouse intestinal tract or epithelial cell differentiation.
Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described.
gasdermin domain containing 1
, gasdermin D
, gasdermin domain-containing protein 1