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Gasdermin D is a member of the gasdermin family. Additionally we are shipping Gasdermin D Antibodies (32) and Gasdermin D Kits (3) and many more products for this protein.
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Gene deletion of GSDMD demonstrated that GSDMD is required for pyroptosis and for the secretion but not proteolytic maturation of IL-1beta (show IL1B Proteins) in both canonical and non-canonical inflammasome responses.
GSDMD N-terminal cleavage product oligomerizes in membranes to form pores that are visible by electron microscopy
caspase-1 and caspase-4/5/11 specifically cleaved the linker between the amino-terminal gasdermin-N and carboxy-terminal gasde (show DCLRE1C Proteins)rmin-C domains in GSDM (show CASP4 Proteins)D, which was re (show CASP1 Proteins)quired and sufficient for pyroptosis
Study investigated the expression pattern of the GSDM (show GSDMA Proteins) family genes in the upper gastrointestinal epithelium and cancers.
identification of gasdermin D (Gsdmd) by genome-wide clustered regularly interspaced palindromic repeat (CRISPR)-Cas9 nuclease (show DCLRE1C Proteins) screens of caspase-11 (show CASP4 Proteins)- and caspase-1 (show CASP1 Proteins)-mediated pyroptosis in mouse bone marrow macrophages
gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1beta maturation
This study clearly shows that Gsdmd is not essential for development of mouse intestinal tract or epithelial cell differentiation.
Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described.
gasdermin domain containing 1
, gasdermin D
, gasdermin domain-containing protein 1