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anti-Gastric Inhibitory Polypeptide Receptor (GIPR) Antibodies

GIPR encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Additionally we are shipping GIPR Kits (5) and GIPR Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GIPR 2696 P48546
GIPR 381853 Q0P543
GIPR 25024 P43219
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Top anti-GIPR Antibodies at antibodies-online.com

Showing 10 out of 100 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of GIPR antibody (N-term) (ABIN391714) in HL60 cell line lysates (35 µg/lane). GIPR (arrow) was detected using the purified polyclonal antibody. GIPR Antibody (N-term) (ABIN391714)immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of GIPR Antibody (Center) in MDA-MB231 cell line lysates (35ug/lane). GIPR (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB Host: RabbitTarget Name: GIPRAntibody Dilution: 1.0ug/mlSample Tissue: 293T cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using GIPR Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of MCF7 cells, using GIPR Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of GIPR Antibody (Center) (ABIN652353) in MDA-MB231 cell line lysates (35 µg/lane). GIPR (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemical staining of human pancreas using antibody ABIN122254 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (p) Anti-GIPR antibody  ABIN1048658 IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p) Anti-GIPR antibody  ABIN1048660 IHC staining of human pancreas, islet of Langerhans. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Mouse splenocytes probed with Rabbit Anti-GIPR Polyclonal Antibody, Unconjugated . 100 μL Log in to see 14 to 21 Days
$269.50
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details

GIPR Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-GIPR Antibodies

  1. Human Polyclonal GIPR Primary Antibody for FACS, IHC (p) - ABIN391714 : Ugleholdt, Pedersen, Bassi, Füchtbauer, Jørgensen, Kissow, Nytofte, Poulsen, Rosenkilde, Seino, Thams, Holst, Holst: Transgenic rescue of adipocyte glucose-dependent insulinotropic polypeptide receptor expression restores high fat diet-induced body weight gain. in The Journal of biological chemistry 2011 (PubMed)

More Antibodies against GIPR Interaction Partners

Human Gastric Inhibitory Polypeptide Receptor (GIPR) interaction partners

  1. Study shows the internalization of GIPR involving clathrin-coated pits, AP-2 (show GTF3A Antibodies) and dynamin (show DNM1 Antibodies) and its subsequent intracellular trafficking. GIP (show GIP Antibodies) stimulates a rapid robust internalization of the GIPR, the major part being directed to lysosomes.

  2. The common variant rs10423928 in the GIPR gene is associated with increased risk of stroke in patients with type 2 diabetes.

  3. Body mass index change for the A/T+A/A in GIPR genotypes was significantly higher than that for the T/T genotype. rs10423928 may predict weight gain in schizophrenia.

  4. The potential future role of gastric inhibitory peptide (GIP (show GIP Antibodies)) receptors as molecular targets in neuroendocrine neoplasms may be dependent on the tumor grade.

  5. Results show that GIPR undergoes trafficking between the plasma membrane and intracellular compartments of both GIP (show GIP Antibodies)-stimulated and unstimulated adipocytes.

  6. GIPR is overexpressed in gastric and duodenal neuroendocrine tumors

  7. GIPR expression was downregulated in subcutaneous adipose tissue from obese patients and correlated negatively with body mass index, waist circumference, systolic blood pressure, and glucose and triglyceride levels.

  8. GIPR promoter was hypomethylated in type 2 diabetic patients as compared to controls.

  9. This study demonstrates an association between a functional GIPR polymorphism Glu354Gln (rs1800437) and Bone mineral density and fracture risk.

  10. Compared with the current treatment standard SSTR2 (show SSTR2 Antibodies), GIPR has only somewhat lesser absolute gene expression in tumor tissue but much lesser expression in normal tissue, making it a promising new target for neuroendocrine tumor imaging and therapy.

Mouse (Murine) Gastric Inhibitory Polypeptide Receptor (GIPR) interaction partners

  1. Gipr(-/-) offspring of mice exposed to high fat diet(HFD) during pregnancy/lactation became insulin (show INS Antibodies) resistant and obese and exhibited increased adipose tissue inflammation and decreased peripheral tissue substrate utilization after reintroduction of HFD.

  2. Beta-cell Gipr KO mice exhibit lower levels of meal-stimulated insulin (show INS Antibodies) secretion, decreased expansion of adipose tissue mass and preservation of insulin (show INS Antibodies) sensitivity and decreased TCF1 (show HNF1A Antibodies) expression.

  3. Gipr is expressed in healthy arteries, predominantly in endothelial cells.

  4. These data highlighted the importance of intact GIPR signalling and dietary composition in modulating memory and learning, and hippocampal pathways involved in the maintenance of synaptic plasticity

  5. Functional GIP (show GIP Antibodies) receptors play a major role in islet compensatory response to high fat feeding in mice.

  6. our data demonstrate that the expression of GLP-1R (show GLP1R Antibodies) and GIPR is regulated by glucose (show ZNF236 Antibodies) concentrations in MC3T3-E1 cells undergoing differentiation induced by BMP-2 (show BMP2 Antibodies).

  7. Results show that GIPR undergoes trafficking between the plasma membrane and intracellular compartments of both GIP (show GIP Antibodies)-stimulated and unstimulated adipocytes.

  8. Structural and pharmacological characterization of novel potent and selective monoclonal antibody antagonists of glucose-dependent insulinotropic polypeptide receptor.

  9. a role of the adipocyte GIPr in nutrient-dependent regulation of body weight and lean mass, but it does not support a direct and independent role for the adipocyte or beta-cell GIPr in promoting adipogenesis.

  10. Gipr is essential for adrenal steroidogenesis and links high fat (HF) feeding to increased levels of corticosterone, reduced glucocorticoid levels do not significantly contribute to the enhanced metabolic phenotypes in HF-fed Gipr(-/-) mice.

Golden Syrian Hamster Gastric Inhibitory Polypeptide Receptor (GIPR) interaction partners

  1. Data suggest that high levels of blood glucose or AGEs (advanced glycation end products), as seen in hyperglycemia, reduce secretion of insulin (show INS Antibodies) by pancreatic beta cells via antagonism of GIP (gastric inhibitory polypeptide (show GIP Antibodies))/GIP (show GIP Antibodies) receptor signaling.

GIPR Antigen Profile

Protein Summary

This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes.

Gene names and symbols associated with GIPR

  • gastric inhibitory polypeptide receptor (GIPR) antibody
  • gastric inhibitory polypeptide receptor (LOC100350463) antibody
  • gastric inhibitory polypeptide receptor (Gipr) antibody
  • GIP-R antibody
  • Gippr antibody
  • GIPR antibody
  • Gm160 antibody
  • Gm1081 antibody
  • PGQTL2 antibody
  • RATGIPPR antibody

Protein level used designations for GIPR

gastric inhibitory polypeptide receptor , glucagon receptor , gastric inhibitory polypeptide receptor-like , GIP-R , glucose-dependent insulinotropic polypeptide receptor , gastric inhibitory peptide receptor

GENE ID SPECIES
100170666 Ovis aries
100303705 Meleagris gallopavo
745427 Pan troglodytes
484439 Canis lupus familiaris
100350463 Oryctolagus cuniculus
100410438 Callithrix jacchus
100432362 Pongo abelii
2696 Homo sapiens
381853 Mus musculus
25024 Rattus norvegicus
101844713 Mesocricetus auratus
617879 Bos taurus
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