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Gastric Inhibitory Polypeptide Receptor Proteins (GIPR)

GIPR encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Additionally we are shipping GIPR Antibodies (172) and GIPR Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GIPR 2696 P48546
GIPR 381853 Q0P543
Rat GIPR GIPR 25024 P43219
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Top GIPR Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details

GIPR Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
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Mouse (Murine) ,
,

More Proteins for Gastric Inhibitory Polypeptide Receptor (GIPR) Interaction Partners

Human Gastric Inhibitory Polypeptide Receptor (GIPR) interaction partners

  1. Study shows the internalization of GIPR involving clathrin-coated pits, AP-2 (show GTF3A Proteins) and dynamin (show DNM1 Proteins) and its subsequent intracellular trafficking. GIP (show GIP Proteins) stimulates a rapid robust internalization of the GIPR, the major part being directed to lysosomes.

  2. The common variant rs10423928 in the GIPR gene is associated with increased risk of stroke in patients with type 2 diabetes.

  3. Body mass index change for the A/T+A/A in GIPR genotypes was significantly higher than that for the T/T genotype. rs10423928 may predict weight gain in schizophrenia.

  4. The potential future role of gastric inhibitory peptide (GIP (show GIP Proteins)) receptors as molecular targets in neuroendocrine neoplasms may be dependent on the tumor grade.

  5. Results show that GIPR undergoes trafficking between the plasma membrane and intracellular compartments of both GIP (show GIP Proteins)-stimulated and unstimulated adipocytes.

  6. GIPR is overexpressed in gastric and duodenal neuroendocrine tumors

  7. GIPR expression was downregulated in subcutaneous adipose tissue from obese patients and correlated negatively with body mass index, waist circumference, systolic blood pressure, and glucose and triglyceride levels.

  8. GIPR promoter was hypomethylated in type 2 diabetic patients as compared to controls.

  9. This study demonstrates an association between a functional GIPR polymorphism Glu354Gln (rs1800437) and Bone mineral density and fracture risk.

  10. Compared with the current treatment standard SSTR2 (show SSTR2 Proteins), GIPR has only somewhat lesser absolute gene expression in tumor tissue but much lesser expression in normal tissue, making it a promising new target for neuroendocrine tumor imaging and therapy.

Mouse (Murine) Gastric Inhibitory Polypeptide Receptor (GIPR) interaction partners

  1. Gipr(-/-) offspring of mice exposed to high fat diet(HFD) during pregnancy/lactation became insulin (show INS Proteins) resistant and obese and exhibited increased adipose tissue inflammation and decreased peripheral tissue substrate utilization after reintroduction of HFD.

  2. Beta-cell Gipr KO mice exhibit lower levels of meal-stimulated insulin (show INS Proteins) secretion, decreased expansion of adipose tissue mass and preservation of insulin (show INS Proteins) sensitivity and decreased TCF1 (show HNF1A Proteins) expression.

  3. Gipr is expressed in healthy arteries, predominantly in endothelial cells.

  4. These data highlighted the importance of intact GIPR signalling and dietary composition in modulating memory and learning, and hippocampal pathways involved in the maintenance of synaptic plasticity

  5. Functional GIP (show GIP Proteins) receptors play a major role in islet compensatory response to high fat feeding in mice.

  6. our data demonstrate that the expression of GLP-1R (show GLP1R Proteins) and GIPR is regulated by glucose concentrations in MC3T3-E1 cells undergoing differentiation induced by BMP-2 (show BMP2 Proteins).

  7. Results show that GIPR undergoes trafficking between the plasma membrane and intracellular compartments of both GIP (show GIP Proteins)-stimulated and unstimulated adipocytes.

  8. Structural and pharmacological characterization of novel potent and selective monoclonal antibody antagonists of glucose-dependent insulinotropic polypeptide receptor.

  9. a role of the adipocyte GIPr in nutrient-dependent regulation of body weight and lean mass, but it does not support a direct and independent role for the adipocyte or beta-cell GIPr in promoting adipogenesis.

  10. Gipr is essential for adrenal steroidogenesis and links high fat (HF) feeding to increased levels of corticosterone, reduced glucocorticoid levels do not significantly contribute to the enhanced metabolic phenotypes in HF-fed Gipr(-/-) mice.

Golden Syrian Hamster Gastric Inhibitory Polypeptide Receptor (GIPR) interaction partners

  1. Data suggest that high levels of blood glucose or AGEs (advanced glycation end products), as seen in hyperglycemia, reduce secretion of insulin (show INS Proteins) by pancreatic beta cells via antagonism of GIP (gastric inhibitory polypeptide (show GIP Proteins))/GIP (show GIP Proteins) receptor signaling.

GIPR Protein Profile

Protein Summary

This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes.

Gene names and symbols associated with GIPR

  • gastric inhibitory polypeptide receptor (GIPR)
  • gastric inhibitory polypeptide receptor (LOC100350463)
  • gastric inhibitory polypeptide receptor (Gipr)
  • GIP-R protein
  • Gippr protein
  • GIPR protein
  • Gm160 protein
  • Gm1081 protein
  • PGQTL2 protein
  • RATGIPPR protein

Protein level used designations for GIPR

gastric inhibitory polypeptide receptor , glucagon receptor , gastric inhibitory polypeptide receptor-like , GIP-R , glucose-dependent insulinotropic polypeptide receptor , gastric inhibitory peptide receptor

GENE ID SPECIES
100170666 Ovis aries
100303705 Meleagris gallopavo
745427 Pan troglodytes
484439 Canis lupus familiaris
100350463 Oryctolagus cuniculus
100410438 Callithrix jacchus
100432362 Pongo abelii
2696 Homo sapiens
381853 Mus musculus
25024 Rattus norvegicus
101844713 Mesocricetus auratus
617879 Bos taurus
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