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GRP encodes a member of the bombesin-like family of gastrin-releasing peptides. Additionally we are shipping Gastrin-Releasing Peptide Antibodies (127) and Gastrin-Releasing Peptide Kits (34) and many more products for this protein.
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Fos and phosphorylation of extracellular signal-regulated kinases (ERK (show EPHB2 Proteins)) were used to look for evidence that interneurons expressing GRP (show UCMA Proteins) were activated following intradermal injection of chloroquine.
GRP (show UCMA Proteins) is expressed by a distinct population of excitatory interneurons in laminae I-II that are likely to be involved in the itch pathway
BNP-NPRA (show NPR1 Proteins) signaling is involved in both itch and pain and does not function upstream of the GRP (show UCMA Proteins)-GRPR (show GRPR Proteins) dedicated neuronal pathway.
The majority of dorsal spinal cord Grp is synthesized locally in dorsal spinal cord neurons while Nmb is highly expressed in pain- and itch-sensing dorsal root ganglion neurons.
nonamidated peptides derived from the C terminus of pro-GRP (show UCMA Proteins) are expressed in significant quantities in colorectal cancer cell lines
GRP (show UCMA Proteins) delays the phase of the clock during the early night by prolonging day-like membrane properties of SCN (show SRI Proteins) cells
The GRP (show UCMA Proteins) receptor system does not mediate kappa opioid receptor (show OPRK1 Proteins) antagonist (GNTI (show MGAT1 Proteins))-induced scratching. The kappa opioid system is involved, at least in part, in the scratch suppressing activity of the kappa opioid receptor (show OPRK1 Proteins) agonist nalfurafine.
These studies demonstrate that (64)Cu-SarAr-SA-Aoc-bombesin(7-14) and (64)Cu-SarAr-SA-Aoc-GSG-bombesin(7-14) bound with high affinity to GRPR (show GRPR Proteins)-expressing cells.
A general possible effect of GRP (show UCMA Proteins) on cortical inhibitory transmission, was shown.
GRP/GRP (show UCMA Proteins)-R (show GRPR Proteins) play a transient and non-critical role in intestinal development
CEA (show CEACAM5 Proteins), NSE (show ENO2 Proteins), CA125 (show MUC16 Proteins) and pro-GRP (show LSM4 Proteins) could serve as biomarkers for SCLC, and CEA (show CEACAM5 Proteins) and CYFRA21-1 could serve as biomarkers for NSCLC. Pro-GRP (show LSM4 Proteins), CA125 (show MUC16 Proteins) and CEA (show CEACAM5 Proteins) were related to the clinical stages of lung cancer
Data show that serum neuron-specific enolase (show ENO2 Proteins), cytokeratin 19 (show KRT19 Proteins) fragment 21-1, pro-gastrin-releasing peptide, squamous cell carcinoma antigen, tissue inhibitor of metalloproteinase-1, and human epididymis protein 4 are not associated with brain metastases.
No association of 16 GRP (show LSM4 Proteins) and 7 GRPR (show GRPR Proteins) variants were found with agoraphobia with/without panic disorder.
the role of autophagy in the degradation of gastrin-releasing peptide and subsequent inhibition of angiogenesis
The Gastrin-releasing peptide(GRP)triggers the growth of HepG2 cells through blocking the ER stress-mediated pathway.
GRP (show LSM4 Proteins) silencing decreases anchorage-independent growth, inhibits cell migration and neuroblastoma (show ARHGEF16 Proteins) cell-mediated angiogenesis.
GRP (show LSM4 Proteins)-expressing C and A delta fibers that coexpress SP or CGRP (show S100A12 Proteins) makes these neurons pruriceptors.
The levels of GRP (show LSM4 Proteins) were upregulated in cells treated with HGF (show HGF Proteins) in a dose-dependent manner. HGF (show HGF Proteins)-induced expression of Ets-1 (show ETS1 Proteins) and IL-8 (show IL8 Proteins) was increased more by GRP (show LSM4 Proteins) treatment.
GRP (show LSM4 Proteins) serum level is higher in patients with pruritus in patients with atopic dermatitis.
Tonic stretch of human myometrium increases contractility and stimulates the expression of a known smooth muscle stimulatory agonist, GRP (show LSM4 Proteins). GRP (show LSM4 Proteins) receptor antagonists attenuate the effect of stretch.
GRP may be important both in the endometrial remodeling during the estrous cycle and in the implantation and development of blastocysts
The present results revealed the localization of GRP in the uterine gland cells at light- and electron-microscopic levels and suggested the release of GRP from the cell into the lumen of the gland by exocrine manner.
GRP may be important both in the development of the fetal cervix and secretory activity of the epithelial cells of the cervix.
This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different isoforms.
, neuromedin C
, pre-progastrin releasing peptide
, proventricular peptide
, submandibular gland secretory Glx-rich protein
, uncharacterized protein LOC232426
, Gla-rich protein
, unique cartilage matrix-associated protein