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The protein encoded by GKN1 is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa. Additionally we are shipping Gastrokine 1 Antibodies (86) and Gastrokine 1 Kits (38) and many more products for this protein.
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Human Gastrokine 1 Protein expressed in Escherichia coli (E. coli) - ABIN1098387
Martin, Powell, Wang, Bhattacharyya, Walsh-Reitz, Agarwal, Toback: A novel mitogenic protein that is highly expressed in cells of the gastric antrum mucosa. in American journal of physiology. Gastrointestinal and liver physiology 2003
Show all 2 references for ABIN1098387
Human Gastrokine 1 Protein expressed in Wheat germ - ABIN1355172
Fahlbusch, Ruebner, Huebner, Volkert, Zuern, Thiel, Koch, Menendez-Castro, Wachter, Hartner, Rascher: The tumor suppressor gastrokine-1 is expressed in placenta and contributes to the regulation of trophoblast migration. in Placenta 2013
Gastrokine 1 indirectly participates in actin stabilization since its overexpression in gastric cancer cells strongly increases the expression of tight and adherens junction proteins
AMP-18 appears to act through PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) pathways to increase p21 (show CDKN1A Proteins) phosphorylation, thereby reducing its nuclear accumulation to overcome the antiproliferative effects of TNF-alpha (show TNF Proteins).
Results suggest a potential association between CRP and GPC5 variants with lung cancer risk; variation in GKN1 is associated with chemotherapy response in the Chinese Han population.
GKN1 inhibits metastasis in gastric cancer cells.
GKN1 may shorten telomeres by acting as a potential c-myc (show MYC Proteins) inhibitor that eventually leads to senescence and apoptosis in gastric cancer cells
GKN1 expression in the gastric mucosa of gastric cancer patients is decreased; this is associated with progression and prognosis of gastric cancer.
Data show that recombinant gastrokine 1 (GKN1) interacts with amyloid-beta peptide (1-40) preventing its aggregation.
These results suggest that GKN1 might be a target to inhibit the effects from H.pylori CagA (show S100A8 Proteins).
Low GKN1 activity is associated with gastric cancers.
Epstein-Barr virus EBNA1 binds to the divergent promoter of the GKN1 and GKN2 genes and contributes to the complex transcriptional and epigenetic deregulation of the GKN1 and GKN2 tumor suppressor genes.
The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa.
, 18 kDa antrum mucosa protein
, protein CA11 homolog
, BRICHOS domain containing 1