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Regulator of DNA replication. Additionally we are shipping Geminin Coiled-Coil Domain Containing Antibodies (24) and and many more products for this protein.
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The crystal structure of a GemC1 coiled-coil domain variant engineered for better solubility was determined to 2.2 A resolution.
The authors found that GEMC1-deficient mice are growth impaired, develop hydrocephaly with a high penetrance, and are infertile, due to defects in the formation of multiciliated cells in the brain, respiratory tract, and germline.
GemC1 directly transactivates the promoters of MCIDAS and FOXJ1 (show FOXJ1 Proteins).
Results suggest that Mcidas and GemC1 are key players in the generation of multiciliated ependymal cells of the adult neurogenic niche.
GEMC1 promotes initiation of chromosomal DNA replication in multicellular organisms by mediating TopBP1 (show TOPBP1 Proteins)- and Cdk2 (show CDK2 Proteins)-dependent recruitment of Cdc45 (show CDC45 Proteins) onto replication origins.
Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2- dependent recruitment of CDC45L onto replication origins (By similarity).
geminin coiled-coil domain-containing protein 1
, GEMinin-containing coiled-coil domain 1
, replication factor GEMC1