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GGPS1 is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. Additionally we are shipping GGPS1 Antibodies (126) and GGPS1 Proteins (22) and many more products for this protein.
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GGPS1 is a key gene in the chlorophyll biosynthetic pathway.
results may support a model in which accumulation of susceptibility variants (including some in relevant genes, notably GGPS1) may lead to a possible genetic component of predisposition to atypical femoral fractures.
GGPPS1 may play a critical role during the development of HCC (show FAM126A ELISA Kits) from cirrhosis and is of clinical significance for predicting biological character of HCC (show FAM126A ELISA Kits).
Egr-1 (show EGR1 ELISA Kits) most likely does not induce the constitutive activation of Erk1/2 (show MAPK1/3 ELISA Kits) through its target gene GGPS1.
the Egr-1 (show EGR1 ELISA Kits)/GGPPS/Erk1/2 (show MAPK1/3 ELISA Kits) pathway is responsible for insulin (show INS ELISA Kits) resistance during hyperinsulinism
these results reveal a new EGR-1 (show EGR1 ELISA Kits)/GGPPS/MAPK (show MAPK1 ELISA Kits) signaling pathway that controls cigarette smoke-induced pulmonary inflammation.
Study suggested that GGPS1 -8188A ins (show INS ELISA Kits)/del polymorphism may confer susceptibility to femoral neck BMD (show BEST1 ELISA Kits) response to bisphosphonate therapy in Korean women.
Farnesyltranstransferase mutations are associated with lonafarnib resistance
Evidence for a non-membrane bound isoform of geranylgeranyl diphosphate synthase 1 in rat.
Depletion of GGPP in mouse oocytes impaired the proliferation of granulosa cells, primary-secondary follicle transition and female fertility. GGPP depletion inhibited Rho GTPase (show RACGAP1 ELISA Kits) geranylgeranylation and its GTPase (show RACGAP1 ELISA Kits) activity.
our data suggest that GGPPS is essential for maintaining fetal lung branching morphogenesis, which is possibly through regulating K-Ras prenylation.
GGPPS-controlled protein geranylgeranylation, which regulates formation of the insulin (show INS ELISA Kits) granule docked pool, is critical for beta cell function and insulin (show INS ELISA Kits) release during the development of type 2 diabetes mellitus
findings imply that GGPPS deletion induces hepatocyte apoptosis, which makes the liver vulnerable to hepatotoxicity.
the impact of deleting one copy of FT or GGT (show GGT1 ELISA Kits) on the development of amyloid-beta (Abeta (show APP ELISA Kits))-associated neuropathology and learning/memory impairments in APPPS1 double transgenic mice.
The authors show that an early response transcription factor Egr-1 (show EGR1 ELISA Kits) could tilt the signalling balance by blocking PI3K/Akt (show AKT1 ELISA Kits) signalling through PTEN and augmenting Erk/MAPK (show MAPK1 ELISA Kits) signalling through GGPPS, resulting in insulin (show INS ELISA Kits) resistance in adipocytes.
GGPP is critical for the cell-to-cell contact-induced differentiation, in which the down-regulation of GGPPS might be involved.
This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene.
geranylgeranyl pyrophosphate synthase 1
, geranylgeranyl pyrophosphate synthetase
, geranyl pyrophosphate synthase
, geranylgeranyl pyrophosphate synthase,chloroplastic
, geranylgeranyl diphosphate synthase 1
, (2E,6E)-farnesyl diphosphate synthase
, GGPP synthase
, farnesyl diphosphate synthase
, geranylgeranyl pyrophosphate synthase
, GGPP synthetase