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Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. Additionally we are shipping Germ Cell Associated 2 (Haspin) Antibodies (48) and and many more products for this protein.
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Haspin kinase plays a key role in maintaining the slowly exchanging centromere Borealin (show CDCA8 Proteins) pool.
Haspin activity affects the phosphorylation state of proteins involved in gene expression regulation and splicing.
Haspin inhibitors reveal centromeric roles of Aurora B (show AURKB Proteins) in chromosome movement and spindle checkpoint signaling
Aurora B (show AURKB Proteins) phosphorylates Haspin to promote generation of H3T3ph and that Aurora B kinase (show AURKB Proteins) activity is required for normal chromosomal localization of the CPC, indicating an intimate linkage between Aurora B (show AURKB Proteins) and Haspin functions in mitosis
findings show phosphorylation of histone H3-threonine 3 mediated by Haspin cooperates with Bub1-mediated histone 2A-serine 121 phosphorylation in targeting the chromosomal passenger complex to the inner centromere in fission yeast and human cells
phosphorylation of H3T3 by Haspin is necessary for chromosomal passenger complex(CPC) accumulation at centromeres; Survivin (show BIRC5 Proteins) binds to H3T3ph; H3T3ph generated by Haspin positions CPC at centromeres to regulate selected targets of Aurora B (show AURKB Proteins) during mitosis
Haspin-depleted cells reveal that spindle-pole integrity in mitosis requires chromosome cohesion.
Haspin is a relatively newly discovered kinase that phosphorylates histone H3 (show HIST3H3 Proteins) during mitosis and appears to play a role in regulating chromosome behavior during cell division. [REVIEW]
This work reveals a new kinase involved in composing the histone code and adds haspin to the select group of kinases that integrate regulation of chromosome and spindle function during mitosis and meiosis
Haspin is required to maintain centromeric cohesion during mitosis.
Data implicate haspin as a regulator of the chromosomal passenger complex and chromosome segregation during meiosis I.
the tissue-dependent and differentially methylated region functions as a modulator in a DNA methylation (show HELLS Proteins)-dependent manner; Gsg2 is under epigenetic control
the 193-bp DNA sequence in Haspin promotor is sufficient for the specific, bidirectional, and synchronous expression in germ cells in the testis.
Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle (By similarity).
serine/threonine-protein kinase haspin-like protein
, germ cell associated 2 (haspin)
, putative serine/threonine-protein kinase haspin homolog
, germ cell-specific gene 2 protein
, haploid germ cell-specific nuclear protein kinase
, serine/threonine-protein kinase haspin