anti-Germ Cell Associated 2 (Haspin) (GSG2) Antibodies

Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. Additionally we are shipping Germ Cell Associated 2 (Haspin) Proteins (7) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GSG2 83903 Q8TF76
GSG2 687827  
GSG2 14841 Q9Z0R0
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Top anti-Germ Cell Associated 2 (Haspin) Antibodies at antibodies-online.com

Showing 10 out of 53 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-GSG2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: 721_B cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-GSG2 Antibody Titration: 1.0 ug/ml Positive Control: Placenta 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Haspin Antibody (R330) (ABIN1882168) western blot analysis in Daudi,Raji cell line lysates (35 µg/lane). This demonstrates the Haspin antibody detected the Haspin protein (arrow). Haspin Antibody (R330) (ABIN1882168) western blot analysis in Daudi,Raji cell line lysates (35 µg/lane). This demonstrates the Haspin antibody detected the Haspin protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Dog Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated IHC (p), IP, IHC, WB Immunohistochemistry-Paraffin: GSG2 Antibody [NBP1-26626] - Human prostate carcinoma. Antibody used at a dilution of 1:200. 0.1 mL Log in to see 7 to 9 Days
$486.94
Details
Human Rabbit Cy7 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit FITC IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit HRP IHC (p), WB   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Cy5.5 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details

GSG2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Germ Cell Associated 2 (Haspin) Antibodies

  1. Human Polyclonal GSG2 Primary Antibody for IHC (p), WB - ABIN1882168 : Dai, Sultan, Taylor, Higgins: The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. in Genes & development 2005 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal GSG2 Primary Antibody for WB - ABIN949715 : Wang, Wei, Du, Cao, Zhang, Liu, Liu, Chen, Ma: H3 Thr3 phosphorylation is crucial for meiotic resumption and anaphase onset in oocyte meiosis. in Cell cycle (Georgetown, Tex.) 2016 (PubMed)

More Antibodies against Germ Cell Associated 2 (Haspin) Interaction Partners

Fruit Fly (Drosophila melanogaster) Germ Cell Associated 2 (Haspin) (GSG2) interaction partners

Human Germ Cell Associated 2 (Haspin) (GSG2) interaction partners

  1. This is the first structural model of a bisubstrate inhibitor targeting haspin. The presented structural data represent a model for the future development of more specific haspin inhibitors

  2. Haspin kinase plays a key role in maintaining the slowly exchanging centromere Borealin (show CDCA8 Antibodies) pool.

  3. Haspin activity affects the phosphorylation state of proteins involved in gene expression regulation and splicing.

  4. Haspin inhibitors reveal centromeric roles of Aurora B (show AURKB Antibodies) in chromosome movement and spindle checkpoint signaling

  5. Aurora B (show AURKB Antibodies) phosphorylates Haspin to promote generation of H3T3ph and that Aurora B kinase (show AURKB Antibodies) activity is required for normal chromosomal localization of the CPC, indicating an intimate linkage between Aurora B (show AURKB Antibodies) and Haspin functions in mitosis

  6. findings show phosphorylation of histone H3-threonine 3 mediated by Haspin cooperates with Bub1-mediated histone 2A-serine 121 phosphorylation in targeting the chromosomal passenger complex to the inner centromere in fission yeast and human cells

  7. phosphorylation of H3T3 by Haspin is necessary for chromosomal passenger complex(CPC) accumulation at centromeres; Survivin (show BIRC5 Antibodies) binds to H3T3ph; H3T3ph generated by Haspin positions CPC at centromeres to regulate selected targets of Aurora B (show AURKB Antibodies) during mitosis

  8. Haspin-depleted cells reveal that spindle-pole integrity in mitosis requires chromosome cohesion.

  9. Haspin is a relatively newly discovered kinase that phosphorylates histone H3 (show HIST3H3 Antibodies) during mitosis and appears to play a role in regulating chromosome behavior during cell division. [REVIEW]

  10. This work reveals a new kinase involved in composing the histone code and adds haspin to the select group of kinases that integrate regulation of chromosome and spindle function during mitosis and meiosis

Mouse (Murine) Germ Cell Associated 2 (Haspin) (GSG2) interaction partners

  1. These data uncover a role for haspin as a regulator of bipolar spindle assembly by regulating AURKC (show AURKC Antibodies) function at acentriolar microtubule-organizing centers in oocytes.

  2. Data implicate haspin as a regulator of the chromosomal passenger complex and chromosome segregation during meiosis I.

  3. the tissue-dependent and differentially methylated region functions as a modulator in a DNA methylation (show HELLS Antibodies)-dependent manner; Gsg2 is under epigenetic control

  4. the 193-bp DNA sequence in Haspin promotor is sufficient for the specific, bidirectional, and synchronous expression in germ cells in the testis.

Germ Cell Associated 2 (Haspin) (GSG2) Antigen Profile

Protein Summary

Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle (By similarity).

Gene names and symbols associated with GSG2

  • serine/threonine-protein kinase haspin-like protein (Haspin) antibody
  • germ cell associated 2 (haspin) (GSG2) antibody
  • CG40080 gene product from transcript CG40080-RA (Haspin) antibody
  • putative serine/threonine-protein kinase haspin homolog (Haspin) antibody
  • germ cell associated 2 (haspin) (Gsg2) antibody
  • germ cell-specific gene 2 (Gsg2) antibody
  • BcDNA:LD07633 antibody
  • CG40080 antibody
  • Dmel\\CG40080 antibody
  • Haspin antibody
  • NV16901 antibody

Protein level used designations for GSG2

serine/threonine-protein kinase haspin-like protein , germ cell associated 2 (haspin) , haspin , CG40080-PA , Haspin-PA , putative serine/threonine-protein kinase haspin homolog , H-haspin , germ cell-specific gene 2 protein , haploid germ cell-specific nuclear protein kinase , serine/threonine-protein kinase haspin

GENE ID SPECIES
552287 Apis mellifera
748101 Pan troglodytes
3355064 Drosophila melanogaster
100122327 Nasonia vitripennis
83903 Homo sapiens
767819 Bos taurus
687827 Rattus norvegicus
14841 Mus musculus
Selected quality suppliers for anti-Germ Cell Associated 2 (Haspin) (GSG2) Antibodies
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