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GHRL encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Additionally we are shipping Ghrelin/obestatin Prepropeptide Kits (131) and Ghrelin/obestatin Prepropeptide Proteins (22) and many more products for this protein.
Showing 10 out of 265 products:
Human Monoclonal GHRL Primary Antibody for WB - ABIN395595
Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010
Show all 5 references for ABIN395595
Human Polyclonal GHRL Primary Antibody for IHC, ELISA - ABIN185450
Ghigo, Broglio, Arvat, Maccario, Papotti, Muccioli: Ghrelin: more than a natural GH secretagogue and/or an orexigenic factor. in Clinical endocrinology 2005
Show all 2 references for ABIN185450
Human Polyclonal GHRL Primary Antibody for EIA, IF - ABIN452691
Stoyanova, Wiertz, Rutten: Time-dependent changes in ghrelin-immunoreactivity in dissociated neuronal cultures of the newborn rat neocortex. in Regulatory peptides 2009
Human Monoclonal GHRL Primary Antibody for IHC (p), ELISA - ABIN565666
Goitein, Lederfein, Tzioni, Berkenstadt, Venturero, Rubin: Mapping of ghrelin gene expression and cell distribution in the stomach of morbidly obese patients--a possible guide for efficient sleeve gastrectomy construction. in Obesity surgery 2012
Human Polyclonal GHRL Primary Antibody for IF (p), IHC (p) - ABIN668991
Lemarié, Beauchamp, Dayot, Duby, Legrand, Rioux: Dietary Caprylic Acid (C8:0) Does Not Increase Plasma Acylated Ghrelin but Decreases Plasma Unacylated Ghrelin in the Rat. in PLoS ONE 2015
Data (including data from studies in cell line from knockout mice) suggest high incorporation of long-chain fatty acids, partly mediated by Acsl1 (show Acsl1 Antibodies), plays role in supply of octanoic acid for ghrelin acylation/lipoylation in ghrelin-producing cells.
Data show that chronic caloric restriction (CR) alters hypothalamic agouti-related protein (Agrp (show AGRP Antibodies)) and neuropeptide Y (Npy (show NPY Antibodies)) gene expression similarly in Ghrelin+/+, Ghrelin-/-, ghrelin receptor Ghsr (show GHSR Antibodies)+/+, and Ghsr (show GHSR Antibodies)-/- mice.
The expression of ghrelin and GH secretagogue receptor 1a [GHSR1a] in cerebral arteries and the effects of ghrelin analogs on cerebrovascular function are reproted.[GHSR1a]
Pax6 (show PAX6 Antibodies) inactivation in the adult pancreas reveals ghrelin as endocrine cell maturation marker.
Thus, GHSR1a differentially inhibits CaV2 (show CAV2 Antibodies) channels by Gi/o or Gq protein pathways depending on its mode of activation.
results demonstrate that ghrelin, which signals acute hunger, renders the olfactory system more responsive to odors
investigated whether ghrelin may cause alteration in neurite outgrowth and electrophysiological properties of tyrosine hydroxylase (show TH Antibodies) neurons from the ventrolateral arcuate nucleus
Ghrelin is an inducer of myoprotective autophagy in myocardial and skeletal muscle ischemia.
The expressions of both ghrelin and its receptor were observed in NPCs using RT-PCR, Interestingly, the exposure of fetal NPCs to ghrelin suppressed their proliferation, and caused them to differentiate into neurons
Co-localization of TRPA1 (show TRPA1 Antibodies) and ghrelin in enteroendocrine cells of the duodenum is observed both in vivo and in the MGN3-1 cell line, a ghrelin secreting cell model, where incubation with CIN (show PDXP Antibodies) up-regulates expression of TRPA1 (show TRPA1 Antibodies) and Insulin receptor (show INSR Antibodies) genes.
Study suggests that ghrelin promotes the growth and osteogenic differentiation of rBMSC primarily through the ERK1/2 (show MAPK1/3 Antibodies) pathway.
Data show that ghrelin was identified in cultured differentiated adipocytes, but did not influence either preadipocyte proliferation or differentiation, indicating that it may have other adipose-related roles.
data provides evidence for the first time in fish of a possible modulatory role of ghrelin on the metabolic regulation by fatty acid of food intake occurring in the hypothalamus
The switch to excessive weight gain in PWS seems to coincide with an increase in the acylated ghrelin/unacylated ghrelin ratio, even prior to the start of hyperphagia.
Plasma ghrelin is higher in HNF1A (show HNF1A Antibodies)-maturity onset diabetes of the young (MODY (show HNF4A Antibodies))and in glucokinase (show GCK Antibodies)-MODY (show HNF4A Antibodies) than in the common polygenic forms of diabetes.
Preproghrelin Leu72Met variation is on the exon 2 with a cytosine (C) to adenine (A) transition at base 408 (+408C>A). Previous studies indicated that this variation was associated with obesity, early onset of obesity and metabolic syndrome.
circulating ghrelin, but not PYY(3-36), levels are increased in neonates with infection, possibly reflecting and/or participating in the inflammatory process
Ghrelin modulates GLUT1 (show SLC2A1 Antibodies) expression and thus indirectly enhances tumor cell proliferation. These findings are of major relevance, because glucose uptake is assumed to be a promising target for cancer treatment.
GH, IGF-1 (show IGF1 Antibodies) and ISI-Matsuda index were lower in the high fatty liver index group in obese subjects with fatty liver and sarcopenia.
Among the gastroesophageal reflux disease patients, ghrelin levels were inversely associated with the frequency and severity of acid regurgitation
the GHRL rs26311 polymorphism is associated with an increased risk to hepatitis B virus-related liver cirrhosis, especially in men.
Ghrelin gene variants -604GA, -501AC and M72L are associated with certain components of metabolic syndrome
Rs4684677 T/A polymorphisms in preproghrelin gene could contribute to development of AITDs in children and T allele is the main risk factor.
Single nucleotide polymorphisms identified in the promoter region of the ghrelin gene could cause changes in the putative transcription factor (show TCF19 Antibodies) binding sites.
The effects of dietary energy on the metabolism of ghrelin, leptin (show LEP Antibodies) and growth hormone secretagogue receptor (show GHSR Antibodies) in blood and tissues of steers are reported.
ghrelin declined after glucose infusion and before the insulin (show INS Antibodies) peak; post-nadir surge in ghrelin may be regulated by the decline in circulating concentrations of glucose and nonesterified fatty acids
present findings suggest that ghrelin may play an important role in regulation of mammary function in lactating dairy goats via GHSR (show GHSR Antibodies)-1a
Studied an alternative vascular approach to the modulation of gastric ghrelin levels..
Obestatin enhances proliferation and differentiation of preadipocytes promoting PPARgamma (show PPARG Antibodies) and C/EBPa (show CEBPA Antibodies) expression, and inhibiting preadipocyte apoptosis by decreasing expression of Caspase-3 (show CASP3 Antibodies), Caspase-7 (show CASP7 Antibodies) and Caspase-9 (show CASP9 Antibodies).
The expression of ghrelin in the digestive tract of low birth weight and normal weight piglets is reported.
Data suggest that a dietary factor (here, high levels of dietary copper) is able to up-regulate expression of ghrelin in the fundic gland of growing pigs; the diets tested in this study also increase feed intake and promote weight gain.
Ghrelin immunolocalization in the gastrointestinal tract of pigs at different ages were studied and it was concluded that gastric ghrelin expression is not related merely to age but could also potentially be influenced by food intake.
BsrI polymorphism at the ghrelin gene locus is potentially associated with carcass and meat quality traits.
Plasma concentrations of ghrelin were greater before feeding and decreased after feeding in pigs fed once per day; there was no consistent pattern to ghrelin secretion in the ad libitum fed group.
glucose output by primary porcine hepatocytes in suspension culture, after incubation with acylated ghrelin (AG), unacylated ghrelin (UAG), and hexarelin (HEX).
Immunization against ghrelin was associated with increased antibody titers, decreased voluntary food consumption, and decreased body weight gain by pigs.
ghrelin mRNA expression is up-regulated 10 days after weaning in the gastric fundus of piglets, coinciding with the increase of H(+)-K(+)-ATPase (show ATP4b Antibodies) mRNA expression and activity
This gene encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and is involved in regulating growth hormone release. Obestatin was initially reported to be an endogenous ligand for the orphan G protein-coupled receptor GPR39 and was involved in satiety and decreased food intake\; however, these findings are controversial. Recent reports show that obestatin is involved in inhibiting thirst and anxiety, improving memory, regulating sleep, affecting cell proliferation, and increasing the secretion of pancreatic juice enzymes. Alternative promoters and alternative splicing result in multiple transcript variants, some of which encode different protein isoforms and some of which do not encode a protein but may regulate the ghrelin-obestatin preproprotein expression. In addition, antisense transcripts for this gene have been identified and may also function in regulation of the ghrelin-obestatin preproprotein expression.
, growth hormone secretagogue
, growth hormone-releasing peptide
, motilin-related peptide
, ghrelin, growth hormone secretagogue receptor ligand
, ghrelin/obestatin preprohormone
, prepro-appetite regulatory hormone
, Appetite-regulating hormone
, Growth hormone secretagogue
, Growth hormone-releasing peptide
, GH releasing peptide
, motilin related peptide
, growth hormone receptor