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GHRL encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Additionally we are shipping Ghrelin/obestatin Prepropeptide Kits (90) and Ghrelin/obestatin Prepropeptide Proteins (19) and many more products for this protein.
Showing 10 out of 256 products:
Human Monoclonal GHRL Primary Antibody for WB - ABIN395595
Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010
Show all 5 references for ABIN395595
Human Polyclonal GHRL Primary Antibody for IHC, ELISA - ABIN185450
Ghigo, Broglio, Arvat, Maccario, Papotti, Muccioli: Ghrelin: more than a natural GH secretagogue and/or an orexigenic factor. in Clinical endocrinology 2005
Show all 2 references for ABIN185450
Human Polyclonal GHRL Primary Antibody for IF (p), IHC (p) - ABIN668991
Lemarié, Beauchamp, Dayot, Duby, Legrand, Rioux: Dietary Caprylic Acid (C8:0) Does Not Increase Plasma Acylated Ghrelin but Decreases Plasma Unacylated Ghrelin in the Rat. in PLoS ONE 2015
Show all 2 references for ABIN668991
Human Monoclonal GHRL Primary Antibody for IHC (p), ELISA - ABIN565666
Goitein, Lederfein, Tzioni, Berkenstadt, Venturero, Rubin: Mapping of ghrelin gene expression and cell distribution in the stomach of morbidly obese patients--a possible guide for efficient sleeve gastrectomy construction. in Obesity surgery 2012
These studies reemphasize the beneficial effects imparted by co-administration of obestatin and CCK8 (show CCK Antibodies) and their potential use towards countering obesity.
Stress in a postpartum mother has persistent effects on the body weight of their offspring. Increased ghrelin and decreased leptin (show LEP Antibodies) expression in the stomach may play a role in these effects.
Data (including data from studies in cell line from knockout mice) suggest high incorporation of long-chain fatty acids, partly mediated by Acsl1 (show Acsl1 Antibodies), plays role in supply of octanoic acid for ghrelin acylation/lipoylation in ghrelin-producing cells.
Data show that chronic caloric restriction (CR) alters hypothalamic agouti-related protein (Agrp (show AGRP Antibodies)) and neuropeptide Y (Npy (show NPY Antibodies)) gene expression similarly in Ghrelin+/+, Ghrelin-/-, ghrelin receptor Ghsr (show GHSR Antibodies)+/+, and Ghsr (show GHSR Antibodies)-/- mice.
The expression of ghrelin and GH secretagogue receptor 1a [GHSR1a] in cerebral arteries and the effects of ghrelin analogs on cerebrovascular function are reproted.[GHSR1a]
Pax6 (show PAX6 Antibodies) inactivation in the adult pancreas reveals ghrelin as endocrine cell maturation marker.
Thus, GHSR1a differentially inhibits CaV2 (show CAV2 Antibodies) channels by Gi/o or Gq protein pathways depending on its mode of activation.
results demonstrate that ghrelin, which signals acute hunger, renders the olfactory system more responsive to odors
investigated whether ghrelin may cause alteration in neurite outgrowth and electrophysiological properties of tyrosine hydroxylase (show TH Antibodies) neurons from the ventrolateral arcuate nucleus
Ghrelin is an inducer of myoprotective autophagy in myocardial and skeletal muscle ischemia.
Study suggests that ghrelin promotes the growth and osteogenic differentiation of rBMSC primarily through the ERK1/2 (show MAPK1/3 Antibodies) pathway.
Data show that ghrelin was identified in cultured differentiated adipocytes, but did not influence either preadipocyte proliferation or differentiation, indicating that it may have other adipose-related roles.
data provides evidence for the first time in fish of a possible modulatory role of ghrelin on the metabolic regulation by fatty acid of food intake occurring in the hypothalamus
Results indicated that expression of the ghrelin/growth hormone secretagogue receptor (show GHSR Antibodies) 1a axis increases the growth of anaplastic astrocytomass and glioblastomas through an autocrine/paracrine mechanism.
GOAT prefers n-hexanoyl-CoA over n-octanoyl-CoA as the acyl donor, although in the stomach the n-octanoyl form is the predominant form of acyl-modified ghrelin.
VO2peak and ghrelin levels increased after 8 weeks aerobic exercise; however, plasma leptin (show LEP Antibodies) and insulin (show INS Antibodies) resistance were not affected by this protocol in male patients with colorectal cancer.
findings suggested the involvement of a GHRL polymorphism in weight gain, which was specifically mediated by appetite change, during antipsychotic treatment in schizophrenia patients.
Data show that serum amylase was found to be correlated with waist circumference, ghrelin and PYY3-36.
Suggest that the effect of exenatide on weight loss may be related with the suppression of serum ghrelin levels.
The concentrations of gastric peptide(Ghrelin and obestatin)and adipocytokines(omentin (show ITLN1 Antibodies) and Apelin (show APLN Antibodies) ) across all subgroups were lower than in the control group. The differences were statistically significant (p < 0.0001), which may be of importance in the development of the disease complications
High serum ghrelin may be protective against the development of hypertension.
Our study provides the first preliminary evidence suggesting that oxidative stress may affect fetal ghrelin levels in humans.
The switch to excessive weight gain in PWS seems to coincide with an increase in the acylated ghrelin/unacylated ghrelin ratio, even prior to the start of hyperphagia.
GHRL is an important candidate gene that may be used to identify genetic variations that influence traits of economic importance in beef cattle
Single nucleotide polymorphisms identified in the promoter region of the ghrelin gene could cause changes in the putative transcription factor (show TCF19 Antibodies) binding sites.
The effects of dietary energy on the metabolism of ghrelin, leptin (show LEP Antibodies) and growth hormone secretagogue receptor (show GHSR Antibodies) in blood and tissues of steers are reported.
ghrelin declined after glucose infusion and before the insulin (show INS Antibodies) peak; post-nadir surge in ghrelin may be regulated by the decline in circulating concentrations of glucose and nonesterified fatty acids
present findings suggest that ghrelin may play an important role in regulation of mammary function in lactating dairy goats via GHSR (show GHSR Antibodies)-1a
slc30A8 (show SLC30A8 Antibodies) colocalizes with ghrelin and motilin (show MLN Antibodies) in the gastrointestinal tract of pigs
Studied an alternative vascular approach to the modulation of gastric ghrelin levels..
Obestatin enhances proliferation and differentiation of preadipocytes promoting PPARgamma (show PPARG Antibodies) and C/EBPa (show CEBPA Antibodies) expression, and inhibiting preadipocyte apoptosis by decreasing expression of Caspase-3 (show CASP3 Antibodies), Caspase-7 (show CASP7 Antibodies) and Caspase-9 (show CASP9 Antibodies).
The expression of ghrelin in the digestive tract of low birth weight and normal weight piglets is reported.
Data suggest that a dietary factor (here, high levels of dietary copper) is able to up-regulate expression of ghrelin in the fundic gland of growing pigs; the diets tested in this study also increase feed intake and promote weight gain.
Ghrelin immunolocalization in the gastrointestinal tract of pigs at different ages were studied and it was concluded that gastric ghrelin expression is not related merely to age but could also potentially be influenced by food intake.
BsrI polymorphism at the ghrelin gene locus is potentially associated with carcass and meat quality traits.
Plasma concentrations of ghrelin were greater before feeding and decreased after feeding in pigs fed once per day; there was no consistent pattern to ghrelin secretion in the ad libitum fed group.
glucose output by primary porcine hepatocytes in suspension culture, after incubation with acylated ghrelin (AG), unacylated ghrelin (UAG), and hexarelin (HEX).
Immunization against ghrelin was associated with increased antibody titers, decreased voluntary food consumption, and decreased body weight gain by pigs.
This gene encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and is involved in regulating growth hormone release. Obestatin was initially reported to be an endogenous ligand for the orphan G protein-coupled receptor GPR39 and was involved in satiety and decreased food intake\; however, these findings are controversial. Recent reports show that obestatin is involved in inhibiting thirst and anxiety, improving memory, regulating sleep, affecting cell proliferation, and increasing the secretion of pancreatic juice enzymes. Alternative promoters and alternative splicing result in multiple transcript variants, some of which encode different protein isoforms and some of which do not encode a protein but may regulate the ghrelin-obestatin preproprotein expression. In addition, antisense transcripts for this gene have been identified and may also function in regulation of the ghrelin-obestatin preproprotein expression.
, growth hormone secretagogue
, growth hormone-releasing peptide
, motilin-related peptide
, ghrelin, growth hormone secretagogue receptor ligand
, ghrelin/obestatin preprohormone
, prepro-appetite regulatory hormone
, Appetite-regulating hormone
, Growth hormone secretagogue
, Growth hormone-releasing peptide
, GH releasing peptide
, motilin related peptide
, growth hormone receptor