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Ghrelin/obestatin Prepropeptide Proteins (GHRL)

GHRL encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Additionally we are shipping Ghrelin/obestatin Prepropeptide Antibodies (264) and Ghrelin/obestatin Prepropeptide Kits (125) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse GHRL GHRL 58991 Q9EQX0
GHRL 51738 Q9UBU3
Rat GHRL GHRL 59301 Q9QYH7
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Top Ghrelin/obestatin Prepropeptide Proteins at

Showing 10 out of 21 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 2 to 3 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 9 to 11 Days
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 3 to 4 Days
HOST_Human Human Un-conjugated   1 mg Log in to see 3 to 4 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μL Log in to see 2 to 3 Days
Human Un-conjugated   1 mg Log in to see 6 Days

GHRL Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,

Top referenced Ghrelin/obestatin Prepropeptide Proteins

  1. Human GHRL Protein expressed in Escherichia coli (E. coli) - ABIN413323 : Iantorno, Chen, Kim, Tesauro, Lauro, Cardillo, Quon: Ghrelin has novel vascular actions that mimic PI 3-kinase-dependent actions of insulin to stimulate production of NO from endothelial cells. in American journal of physiology. Endocrinology and metabolism 2007 (PubMed)

  2. Human GHRL Protein expressed in Escherichia coli (E. coli) - ABIN666671 : Tschöp, Smiley, Heiman: Ghrelin induces adiposity in rodents. in Nature 2000 (PubMed)

More Proteins for Ghrelin/obestatin Prepropeptide (GHRL) Interaction Partners

Mouse (Murine) Ghrelin/obestatin Prepropeptide (GHRL) interaction partners

  1. Data (including data from studies in cell line from knockout mice) suggest high incorporation of long-chain fatty acids, partly mediated by Acsl1 (show Acsl1 Proteins), plays role in supply of octanoic acid for ghrelin acylation/lipoylation in ghrelin-producing cells.

  2. Data show that chronic caloric restriction (CR) alters hypothalamic agouti-related protein (Agrp (show AGRP Proteins)) and neuropeptide Y (Npy (show NPY Proteins)) gene expression similarly in Ghrelin+/+, Ghrelin-/-, ghrelin receptor Ghsr (show GHSR Proteins)+/+, and Ghsr (show GHSR Proteins)-/- mice.

  3. The expression of ghrelin and GH secretagogue receptor 1a [GHSR1a] in cerebral arteries and the effects of ghrelin analogs on cerebrovascular function are reproted.[GHSR1a]

  4. Pax6 (show PAX6 Proteins) inactivation in the adult pancreas reveals ghrelin as endocrine cell maturation marker.

  5. Thus, GHSR1a differentially inhibits CaV2 (show CAV2 Proteins) channels by Gi/o or Gq protein pathways depending on its mode of activation.

  6. results demonstrate that ghrelin, which signals acute hunger, renders the olfactory system more responsive to odors

  7. investigated whether ghrelin may cause alteration in neurite outgrowth and electrophysiological properties of tyrosine hydroxylase (show TH Proteins) neurons from the ventrolateral arcuate nucleus

  8. Ghrelin is an inducer of myoprotective autophagy in myocardial and skeletal muscle ischemia.

  9. The expressions of both ghrelin and its receptor were observed in NPCs using RT-PCR, Interestingly, the exposure of fetal NPCs to ghrelin suppressed their proliferation, and caused them to differentiate into neurons

  10. Co-localization of TRPA1 (show TRPA1 Proteins) and ghrelin in enteroendocrine cells of the duodenum is observed both in vivo and in the MGN3-1 cell line, a ghrelin secreting cell model, where incubation with CIN (show PDXP Proteins) up-regulates expression of TRPA1 (show TRPA1 Proteins) and Insulin receptor (show INSR Proteins) genes.

Rabbit Ghrelin/obestatin Prepropeptide (GHRL) interaction partners

  1. Study suggests that ghrelin promotes the growth and osteogenic differentiation of rBMSC primarily through the ERK1/2 pathway.

Rainbow Trout (Oncorhynchus mykiss) Ghrelin/obestatin Prepropeptide (GHRL) interaction partners

  1. Data show that ghrelin was identified in cultured differentiated adipocytes, but did not influence either preadipocyte proliferation or differentiation, indicating that it may have other adipose-related roles.

  2. data provides evidence for the first time in fish of a possible modulatory role of ghrelin on the metabolic regulation by fatty acid of food intake occurring in the hypothalamus

Human Ghrelin/obestatin Prepropeptide (GHRL) interaction partners

  1. Our study provides the first preliminary evidence suggesting that oxidative stress may affect fetal ghrelin levels in humans.

  2. The switch to excessive weight gain in PWS seems to coincide with an increase in the acylated ghrelin/unacylated ghrelin ratio, even prior to the start of hyperphagia.

  3. Plasma ghrelin is higher in HNF1A (show HNF1A Proteins)-maturity onset diabetes of the young (MODY (show HNF4A Proteins))and in glucokinase (show GCK Proteins)-MODY (show HNF4A Proteins) than in the common polygenic forms of diabetes.

  4. Preproghrelin Leu72Met variation is on the exon 2 with a cytosine (C) to adenine (A) transition at base 408 (+408C>A). Previous studies indicated that this variation was associated with obesity, early onset of obesity and metabolic syndrome.

  5. circulating ghrelin, but not PYY(3-36), levels are increased in neonates with infection, possibly reflecting and/or participating in the inflammatory process

  6. Ghrelin modulates GLUT1 (show SLC2A1 Proteins) expression and thus indirectly enhances tumor cell proliferation. These findings are of major relevance, because glucose uptake is assumed to be a promising target for cancer treatment.

  7. GH, IGF-1 (show IGF1 Proteins) and ISI-Matsuda index were lower in the high fatty liver index group in obese subjects with fatty liver and sarcopenia.

  8. Among the gastroesophageal reflux disease patients, ghrelin levels were inversely associated with the frequency and severity of acid regurgitation

  9. the GHRL rs26311 polymorphism is associated with an increased risk to hepatitis B virus-related liver cirrhosis, especially in men.

  10. Ghrelin gene variants -604GA, -501AC and M72L are associated with certain components of metabolic syndrome

Cow (Bovine) Ghrelin/obestatin Prepropeptide (GHRL) interaction partners

  1. GHRL is an important candidate gene that may be used to identify genetic variations that influence traits of economic importance in beef cattle

  2. Single nucleotide polymorphisms identified in the promoter region of the ghrelin gene could cause changes in the putative transcription factor (show TCF19 Proteins) binding sites.

  3. The effects of dietary energy on the metabolism of ghrelin, leptin (show LEP Proteins) and growth hormone secretagogue receptor (show GHSR Proteins) in blood and tissues of steers are reported.

  4. ghrelin declined after glucose infusion and before the insulin (show INS Proteins) peak; post-nadir surge in ghrelin may be regulated by the decline in circulating concentrations of glucose and nonesterified fatty acids

Goat Ghrelin/obestatin Prepropeptide (GHRL) interaction partners

  1. present findings suggest that ghrelin may play an important role in regulation of mammary function in lactating dairy goats via GHSR (show GHSR Proteins)-1a

Pig (Porcine) Ghrelin/obestatin Prepropeptide (GHRL) interaction partners

  1. slc30A8 (show SLC30A8 Proteins) colocalizes with ghrelin and motilin (show MLN Proteins) in the gastrointestinal tract of pigs

  2. Studied an alternative vascular approach to the modulation of gastric ghrelin levels..

  3. Obestatin enhances proliferation and differentiation of preadipocytes promoting PPARgamma (show PPARG Proteins) and C/EBPa (show CEBPA Proteins) expression, and inhibiting preadipocyte apoptosis by decreasing expression of Caspase-3 (show CASP3 Proteins), Caspase-7 (show CASP7 Proteins) and Caspase-9 (show CASP9 Proteins).

  4. The expression of ghrelin in the digestive tract of low birth weight and normal weight piglets is reported.

  5. Data suggest that a dietary factor (here, high levels of dietary copper) is able to up-regulate expression of ghrelin in the fundic gland of growing pigs; the diets tested in this study also increase feed intake and promote weight gain.

  6. Ghrelin immunolocalization in the gastrointestinal tract of pigs at different ages were studied and it was concluded that gastric ghrelin expression is not related merely to age but could also potentially be influenced by food intake.

  7. BsrI polymorphism at the ghrelin gene locus is potentially associated with carcass and meat quality traits.

  8. Plasma concentrations of ghrelin were greater before feeding and decreased after feeding in pigs fed once per day; there was no consistent pattern to ghrelin secretion in the ad libitum fed group.

  9. glucose output by primary porcine hepatocytes in suspension culture, after incubation with acylated ghrelin (AG), unacylated ghrelin (UAG), and hexarelin (HEX).

  10. Immunization against ghrelin was associated with increased antibody titers, decreased voluntary food consumption, and decreased body weight gain by pigs.

Ghrelin/obestatin Prepropeptide (GHRL) Protein Profile

Protein Summary

This gene encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and is involved in regulating growth hormone release. Obestatin was initially reported to be an endogenous ligand for the orphan G protein-coupled receptor GPR39 and was involved in satiety and decreased food intake\; however, these findings are controversial. Recent reports show that obestatin is involved in inhibiting thirst and anxiety, improving memory, regulating sleep, affecting cell proliferation, and increasing the secretion of pancreatic juice enzymes. Alternative promoters and alternative splicing result in multiple transcript variants, some of which encode different protein isoforms and some of which do not encode a protein but may regulate the ghrelin-obestatin preproprotein expression. In addition, antisense transcripts for this gene have been identified and may also function in regulation of the ghrelin-obestatin preproprotein expression.

Gene names and symbols associated with GHRL

  • ghrelin (Ghrl)
  • ghrelin-like (LOC100349547)
  • ghrelin/obestatin preprohormone (ghrl)
  • ghrelin/obestatin prepropeptide (GHRL)
  • ghrelin/obestatin prepropeptide (Ghrl)
  • 2210006E23Rik protein
  • Gh1-1 protein
  • GHR protein
  • GRHL protein
  • m46 protein
  • MTLRP protein
  • MTLRP-AP protein
  • MTLRPAP protein

Protein level used designations for GHRL

appetite-regulating hormone , growth hormone secretagogue , growth hormone-releasing peptide , motilin-related peptide , preproghrelin , proghrelin , ghrelin , ghrelin, growth hormone secretagogue receptor ligand , ghrelin/obestatin preprohormone , prepro-appetite regulatory hormone , Appetite-regulating hormone , Growth hormone secretagogue , Growth hormone-releasing peptide , prepro-ghrelin , GH releasing peptide , motilin related peptide , growth hormone receptor

58991 Mus musculus
100349547 Oryctolagus cuniculus
100136596 Oncorhynchus mykiss
51738 Homo sapiens
59301 Rattus norvegicus
281192 Bos taurus
100861189 Capra hircus
396728 Sus scrofa
493844 Felis catus
403587 Canis lupus familiaris
442996 Ovis aries
408185 Gallus gallus
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