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Gigaxonin (GAN) ELISA Kits

GAN encodes a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. Additionally we are shipping GAN Antibodies (40) and GAN Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
GAN 209239 Q8CA72
Anti-Rat GAN GAN 307893  
GAN 8139 Q9H2C0
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Top GAN ELISA Kits at antibodies-online.com

Showing 2 out of 7 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.055 ng/mL 0.15-10 ng/mL 96 Tests Log in to see 9 to 11 Days
$736.84
Details
Mouse
  96 Tests Log in to see 11 to 13 Days
$875.60
Details

More ELISA Kits for GAN Interaction Partners

Mouse (Murine) Gigaxonin (GAN) interaction partners

  1. gigaxonin is a major factor in the degradation of cytoskeletal intermediate filaments

  2. GAN variants are identified in brain sections of mutant mice with giant axonal neuropathy.

  3. results identify gigaxonin as a ubiquitin scaffolding protein that controls MAP1B (show MAP1B ELISA Kits)-LC degradation, and provide insight into the molecular mechanisms underlying human neurodegenerative disorders

  4. Disruption of gigaxonin results in an impaired ubiquitin-proteasome system leading to a substantial accumulation of toxic microtubule-associated protein (show SPAG5 ELISA Kits) MAP8 (show MAP1S ELISA Kits) in the null mutants.

  5. At 6 months of age the Gigaxonin-knockout(Deltaexon1;Deltaexon1) mice exhibit a modest hind limb muscle atrophy, a 10% decrease of muscle innervation and a 27% axonal loss in the L5 ventral roots.

Human Gigaxonin (GAN) interaction partners

  1. The disease is caused by GAN gene mutations on chromosome 16q24.1. To determine clinical and genetic results in Turkish patients with GAN.

  2. This study showed that The instability of Gigaxonin causes Giant Axonal Neuropathy.

  3. A novel missense mutation in four siblings born to consanguineous parents of Arab origin with clinical and molecular features compatible with giant axonal neuropathy.

  4. gigaxonin is a major factor in the degradation of cytoskeletal intermediate filaments

  5. No GAN variant is identified in DNA obtained from well-characterized cases of human neuronal intermediate filament inclusion disease (frontotemporal dementia).

  6. Gigaxonin interacts with tubulin folding cofactor B and controls its degradation through the ubiquitin-proteasome pathway.

  7. Ubiquitin-proteasome system shown to be responsible for neurodegeneration occurring in GAN-null neurons and plays crucial roles in cytoskeletal functions and dynamics.

  8. 3 new mutants were found in patients with giant axonal neuropathy: an intronic mutation near the splice donor site of intron 2 & a missense mutation in exon 3 (I182N), & 2 identical deletion alleles.

  9. Five families with GAN for mutations in the Gigaxonin gene and mutations were found in four families; three families had homozygous mutations, one had two compound heterozygous mutations and one family had no mutation identified.

  10. gigaxonin mutations impede this ubiquitin degradation process leading to accumulation of microtubule associated proteins and there by impairing cellular functions

GAN Antigen Profile

Antigen Summary

This gene encodes a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. The encoded protein plays a role in neurofilament architecture and is involved in mediating the ubiquitination and degradation of some proteins. Defects in this gene are a cause of giant axonal neuropathy (GAN).

Gene names and symbols associated with Gigaxonin (GAN) ELISA Kits

  • gigaxonin (gan) antibody
  • gigaxonin (GAN) antibody
  • giant axonal neuropathy (gigaxonin) (GAN) antibody
  • giant axonal neuropathy (Gan) antibody
  • gigaxonin (Gan) antibody
  • A330045G18 antibody
  • GAN antibody
  • GAN1 antibody
  • gigaxonin antibody
  • KLHL16 antibody
  • MGC81691 antibody

Protein level used designations for Gigaxonin (GAN) ELISA Kits

gigaxonin , giant axonal neuropathy , giant axonal neuropathy (gigaxonin) , kelch-like family member 16 , kelch-like protein 16

GENE ID SPECIES
447405 Xenopus laevis
549284 Xenopus (Silurana) tropicalis
713996 Macaca mulatta
100027517 Monodelphis domestica
100339638 Oryctolagus cuniculus
100388790 Callithrix jacchus
100453030 Pongo abelii
100484003 Ailuropoda melanoleuca
100549375 Meleagris gallopavo
100586857 Nomascus leucogenys
430553 Gallus gallus
468044 Pan troglodytes
489694 Canis lupus familiaris
100069891 Equus caballus
209239 Mus musculus
307893 Rattus norvegicus
8139 Homo sapiens
100518489 Sus scrofa
521175 Bos taurus
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