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GCM1 encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). Additionally we are shipping GCM1 Antibodies (40) and many more products for this protein.
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chromosomal localization of the porcine GCM1 gene and the identification and characterization of a GCM1 associated microsatellite marker [GCM1]
GLI2 stabilized glial cell missing-a, a pivotal transcriptional factor for trophoblastic syncytialization.
Gcm1 and Fzd5 function in an evolutionary conserved positive feedback loop that regulates trophoblast differentiation and sites of chorionic branching morphogenesis.
Results suggest that caspase-14 (show CASP14 Proteins) may interact with GCM1 to participate in syncytiotrophoblast differentiation during placental development.
study reveals a novel function for RACK1 (show GNB2L1 Proteins) to regulate GCM1 activity and placental cell migration and invasion
GCM1-directed villous trophoblast differentiation is repressed by DREAM
c-Myc (show MYC Proteins)-regulated members of the miR-17~92 and miR (show MLXIP Proteins)-106a~363 clusters inhibit trophoblast differentiation by repressing GCM1 and CYP19A1 (show CYP19A1 Proteins).
Phorbol 12-myristate 13-acetate-induced protein kinase C and mitogen-activated protein kinase kinase (show MAP2K1 Proteins)/extracellular signal regulated kinase dependent pathway enhances the degradation as well as the transcriptional activity of GCMa.
study reveals a novel function of GCM1 and HtrA4 (show HTRA4 Proteins) in regulation of trophoblast invasion and that abnormal HrtA4 expression may contribute to shallow trophoblast invasion in preeclampsia
Data show that beta-catenin/BCL9 (show ERVW-1 Proteins)-Like (BCL9L)/T-cell factor 4 (TCF4) signalling directly targets t (show BCL9L Proteins)he GCM1/syncytin pathway and thereby regulates the fusion of human choriocarcinoma cells.
results support a role for reduced placental Gcm1 expression as a causative factor in defective syncytiotrophoblast differentiation and maternal and placental phenotypes in preeclampsia in humans.
Data show that the GCM1/syncytin (show ERVW-1 Proteins)-B pathway is significantly downregulated in the placenta of BCL9L (show BCL9L Proteins)-deficient mice and that the fusion and differentiation of ST-II cells are blocked.
as in mice, fetoplacental vascularity increased when GCM1 protein expression decreased (R(2)=-0.45; P<0.05).
Gcm1 (glial cells missing 1) are involved in the epigenetic regulation of Hes5 (show HES5 Proteins) transcription by DNA demethylation independently of DNA replication.
studies identify a novel function of p45NF-E2 (show NFE2 Proteins) during placental development: in trophoblast cells, p45NF-E2 (show NFE2 Proteins) represses Gcm1 and syncytiotrophoblast formation via acetylation
Gcm1 expression defines three stages of chorio-allantoic interaction during placental development
Brief ectopic expression of Gcm1 in mouse embryonic tail bud induces failure of the neural tube to close (spina bifida) and multiple neural tubes (diastematomyelia).
GCM domain as a new type of Zn-coordinating, sequence-specific DNA-binding domain.
mGCMa expression is primarily postnatal, arguing for a role in organ function rather than organ development
the shaping of the maternal blood spaces within the labyrinth was dependent on chorioallantoic morphogenesis and therefore disrupted in Gcm1 mutants
This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein.
glial cells missing homolog 1 (Drosophila)
, chorion-specific transcription factor GCMa
, glial cells missing-like protein 1
, glial cells missing homolog a
, chorion-specific transcription factor GCMa-like
, GCM motif protein 1
, Gcm 1
, Gcm a
, glial cell deficient