Glial Cells Missing Homolog 1 (Drosophila) Proteins (GCM1)

GCM1 encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). Additionally we are shipping GCM1 Antibodies (46) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GCM1 8521 Q9NP62
GCM1 14531 P70348
Rat GCM1 GCM1 29394 Q9Z288
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Top GCM1 Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 10 to 12 Days

GCM1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for Glial Cells Missing Homolog 1 (Drosophila) (GCM1) Interaction Partners

Pig (Porcine) Glial Cells Missing Homolog 1 (Drosophila) (GCM1) interaction partners

  1. chromosomal localization of the porcine GCM1 gene and the identification and characterization of a GCM1 associated microsatellite marker [GCM1]

Human Glial Cells Missing Homolog 1 (Drosophila) (GCM1) interaction partners

  1. Identify a novel cis (show CISH Proteins)-acting sequence (-369 to -320) at the placental growth factor (show PGF Proteins) promoter, which was critical for mediating the basal and DLX3 (show DLX3 Proteins)/GCM1-dependent PGF (show PGF Proteins) promoter activities.

  2. Twist1 (show TWIST1 Proteins) may promote trophoblast syncytialization by regulating the expression of GCM1.

  3. GATA3 (show GATA3 Proteins) knockdown elevated HtrA4 (show HTRA4 Proteins) expression in BeWo and JEG-3 trophoblast cell lines and enhanced the invasion activities of both lines. This study uncovered a new GATA3 (show GATA3 Proteins) function in placenta as a negative regulator of GCM1 activity and trophoblastic invasion.

  4. GLI2 stabilized glial cell missing-a, a pivotal transcriptional factor for trophoblastic syncytialization.

  5. Gcm1 and Fzd5 function in an evolutionary conserved positive feedback loop that regulates trophoblast differentiation and sites of chorionic branching morphogenesis.

  6. Results suggest that caspase-14 (show CASP14 Proteins) may interact with GCM1 to participate in syncytiotrophoblast differentiation during placental development.

  7. study reveals a novel function for RACK1 (show GNB2L1 Proteins) to regulate GCM1 activity and placental cell migration and invasion

  8. GCM1-directed villous trophoblast differentiation is repressed by DREAM

  9. c-Myc (show MYC Proteins)-regulated members of the miR-17~92 and miR (show MLXIP Proteins)-106a~363 clusters inhibit trophoblast differentiation by repressing GCM1 and CYP19A1 (show CYP19A1 Proteins).

  10. Phorbol 12-myristate 13-acetate-induced protein kinase C and mitogen-activated protein kinase kinase (show MAP2K1 Proteins)/extracellular signal regulated kinase dependent pathway enhances the degradation as well as the transcriptional activity of GCMa.

Mouse (Murine) Glial Cells Missing Homolog 1 (Drosophila) (GCM1) interaction partners

  1. GCM1-directed villous trophoblast differentiation is repressed by DREAM

  2. Data show that the GCM1/syncytin (show ERVW-1 Proteins)-B pathway is significantly downregulated in the placenta of BCL9L (show BCL9L Proteins)-deficient mice and that the fusion and differentiation of ST-II cells are blocked.

  3. as in mice, fetoplacental vascularity increased when GCM1 protein expression decreased (R(2)=-0.45; P<0.05).

  4. Gcm1 (glial cells missing 1) are involved in the epigenetic regulation of Hes5 (show HES5 Proteins) transcription by DNA demethylation independently of DNA replication.

  5. studies identify a novel function of p45NF-E2 (show NFE2 Proteins) during placental development: in trophoblast cells, p45NF-E2 (show NFE2 Proteins) represses Gcm1 and syncytiotrophoblast formation via acetylation

  6. Gcm1 expression defines three stages of chorio-allantoic interaction during placental development

  7. Brief ectopic expression of Gcm1 in mouse embryonic tail bud induces failure of the neural tube to close (spina bifida) and multiple neural tubes (diastematomyelia).

  8. GCM domain as a new type of Zn-coordinating, sequence-specific DNA-binding domain.

  9. mGCMa expression is primarily postnatal, arguing for a role in organ function rather than organ development

  10. the shaping of the maternal blood spaces within the labyrinth was dependent on chorioallantoic morphogenesis and therefore disrupted in Gcm1 mutants

GCM1 Protein Profile

Protein Summary

This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein.

Gene names and symbols associated with GCM1

  • glial cells missing homolog 1 (Drosophila) (GCM1)
  • glial cells missing homolog 1 (Drosophila) (Gcm1)
  • GCM protein
  • GCM-1 protein
  • Gcm-rs2 protein
  • GCM1 protein
  • Gcm1-rs1 protein
  • Gcma protein
  • glide protein
  • hGCMa protein

Protein level used designations for GCM1

glial cells missing homolog 1 (Drosophila) , chorion-specific transcription factor GCMa , glial cells missing-like protein 1 , glial cells missing homolog a , chorion-specific transcription factor GCMa-like , GCM motif protein 1 , Gcm 1 , Gcm a , glial cell deficient , mGCM1 , mGCMa

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100341874 Oryctolagus cuniculus
100403173 Callithrix jacchus
100452572 Pongo abelii
100465515 Ailuropoda melanoleuca
100581967 Nomascus leucogenys
8521 Homo sapiens
14531 Mus musculus
29394 Rattus norvegicus
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